Instruction for use: Profenid

Active substance Ketoprofen

ATX code M01AE03 Ketoprofen

Pharmacological group

NSAIDs - Propionic acid derivatives

Nosological classification (ICD-10)

M00-M25 Arthropathy

M05 Seropositive rheumatoid arthritis

Rheumatoid arthritis seropositive

M15-M19 Osteoarthritis

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

M54.3 Sciatica

Ishialgia, Neuralgia of the sciatic nerve, Sciatic neuritis

M71 Other bursopathies

Bursitis, Bursopathy, Diseases of soft tissues, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Subacute bursitis

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

Composition and form of release

1 capsule contains ketoprofen 50 mg; 12 pcs. in the blister, 2 blisters in the box.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, antiaggregational, analgesic.

It blocks cyclooxygenase and inhibits the synthesis of PG.

Pharmacodynamics

It inhibits the exudative and proliferative phase of inflammation, reduces the concentration of PG in the hypothalamic region, increases heat transfer and lowers body temperature, prevents the development of hyperalgesia, suppresses the pain reaction to bradykinin, serotonin, histamine, etc. "mediators" of inflammation. Has antiaggregatory activity (blocks thromboxane synthesis).

Indications

Rheumatoid arthritis, ankylosing spondylitis, degenerative changes in the joints, sciatica, tendon inflammation, periarthritis, bursitis.

Contraindications

Hypersensitivity (including to other NSAIDs), peptic ulcer of the stomach and duodenum, severe liver and kidney failure, pregnancy, lactation (it is necessary to refuse breastfeeding).

Side effects

Nausea, vomiting, diarrhea, less frequent ulceration of the mucous membrane of the digestive tract, bronchospasm; headaches, dizziness, drowsiness, eczema.

Interaction

Enhances the effect of anticoagulants, heparin, ticlopidine, corticosteroid hormones, oral antidiabetic agents, hydantoin derivatives and alcohol. Increases the level of lithium in the blood. Weakens the effect of spironolactone and peripheral vasodilators.

Dosing and Administration

Inside, with food, 100-200 mg (2-4 caps.) Per day, dividing the daily dose by 2-3 doses. Capsules swallow whole.

storage Conditions

Keep out of the reach of children.