Instruction for use: Orciprenaline (Orciprenalinum)

Chemical name: 5- [1-Hydroxy-2 - [(1-methylethyl) amino] ethyl] -1,3-benzenediol (as sulfate or resinate); racemic mixture of two optically active isomers

Pharmacotherapeutic group:

Beta-adrenergic agonist

The nosological classification (ICD-10)

J43 Emphysema

Interstitial emphysema, Emphysema, Chronic lung disease, Chronic obstructive pulmonary disease, Obstructive pulmonary emphysema, Chronic pulmonary emphysema, Chronic obstructive pulmonary emphysema

J44 Other chronic obstructive pulmonary disease

Allergic bronchitis, Bronchitis asthma, Asthmatic bronchitis, wheeze bronchitis, Bronchitis is an obstructive, bronchi disease, Shortness of sputum in acute and chronic respiratory diseases, Cough in inflammatory diseases of the lung and bronchus, Reversible airflow obstruction, Reversible obstructive airway disease, Obstructive bronchitis disease, Obstructive lung disease, Obstructive bronchitis, Spastic bronchitis, Chronic lung disease, Chronic nonspecific lung diseases, Chronic obstructive pulmonary disease, Chronic obstructive bronchitis, Chronic obstructive airway disease, Chronic obstructive pulmonary disease, Restrictive lung pathology

J45 Asthma

Asthma physical effort, status asthmaticus, Bronchial asthma, Asthma lung flow, Bronchial asthma with obstruction of sputum discharge, Bronchial asthma heavy currents, Bronchial asthma physical effort, hypersecretory asthma, Hormone-dependent form of bronchial asthma, Relief of asthma attacks in bronchial asthma, Non-allergic asthma, nocturnal asthma, Exacerbation of asthma, Asthma attacks, Endogenous forms of asthma, Night asthma, Cough with bronchial asthma

O60 Premature birth

Pregnancy prematurity, The birth premature, Preterm labor pains, Premature contractions prehospital, Immobilization of the uterus before the cesarean section, Immobilization of the uterus, Acute tocolysis, Threatening premature labor, Premature discharge of water, Preventing premature births, The threat of premature birth

R00.1 Bradycardia, unspecified

bradyarrhythmias, bradycardia

CAS Cade 586-06-1

Characteristics

The white crystalline powder.

Pharmacology

Pharmacological effect

tocolytic, bronchodilator, anti-asthmatic, warning bronchospasm.

Interacts (mainly) a beta2-adrenoceptor bronchial smooth muscle, activates adenylate cyclase, increasing the amount of cAMP, which leads to a decrease in the concentration of intracellular calcium and bronchodilation. It inhibits the release of biologically active substances from mast cells, improves mucociliary clearance; causing tachycardia and increases myocardial oxygen demand, improve AV conduction, expands peripheral vessels and lowers blood pressure. It has tocolytic properties (activates the beta2-adrenergic receptors in uterine smooth muscle). Depending on the route of administration of 3% is sucked (inhaled) to 10% (enteral). It is metabolized in the liver. Return with faeces.

Indication

Bronchial asthma, obstructive bronchitis, emphysema, pulmonary fibrosis, bradyarrhythmias, AV block, the threat of premature birth.

Contraindications

Hypersensitivity, asthma status, ischemic heart disease, tachyarrhythmia, heart disease, hyperthyroidism, glaucoma.

Side effects of ortciprenaline

Tachycardia, tremor, muscle weakness, decreased blood pressure, headache, dizziness, sweating, nausea, vomiting, addiction, tachyphylaxis.

Interaction

It enhances the effect of antidepressants; when used in conjunction with beta-blockers may phenomenon idiosyncrasy.

Routes of administration

In / in, inside, inhalation. 0.5-1 mg (1.2 ml of 0.05% solution) slowly for 3 minutes, or within 10-20 mg 3-4 times a day (effect after 1 hour and lasts 4-6 hours), or 0.75-1.5 mg inhalations (1-2 puffs) 3-4 times a day (the effect occurs within 15 minutes, reaching a maximum after 1 hour and lasts for 4-5 hours)