Instruction for use: Methoxsalen (Methoxalenum)

Pharmacological group

dermotropic means

Nosological classification (ICD-10)

C84.0 Mushroom mycosis

Mycosis mushroom, Fungoid granuloma

L40 Psoriasis

Chronic psoriasis with diffuse plaques, Generalized psoriasis, Psoriasis of the scalp, Psoriasis of the scalp, Generalized form of psoriasis, Psoriasis dermatitis, Psoriasis complicated by erythroderma, Invalidative psoriasis, Isolated psoriatic plaque, Exfoliative psoriasis, Psoriatic Erythroderma, Psoriasis with eczematosis, Hyperkeratosis in psoriasis,Inverse psoriasis,Psoriasis eczematous, Dermatosis of psoriasis, Psoriasis of the genitals, Psoriasis with lesions of hairy areas of skin, Erythrodermal psoriasis, Chronic psoriasis of the scalp, Chronic psoriasis, Ordinary psoriasis, Refractory psoriasis, Kebner phenomenon, Scaly lichen

L43 Red Leaf Flat

Lishay Wilson, Erosive-ulcerative form of red flat lichen, Warty forms of red lichen, Red lichen, Flat lichen, Kebner phenomenon

L80 Vitiligo

Hypomelanoz, Depigmentation of focal, Leather, pie

CAS 298-81-7

Characteristics of Methoxsalen

Isolated from the seeds of the plant Ammi majus. Refers to psoralens.

Pharmacology

Pharmacological action - photosensitizing.

Forms covalent bonds with DNA, which lead to the formation of mono- and bifunctional compounds that increase the pigment (melanin) content in the skin. Quickly and fairly fully absorbed from the digestive tract. Cmax is created between 0.5 and 4 hours after administration. Reversibly binds to plasma proteins. T1 / 2 about 2 hours. Accumulated in the epidermal cells, rapidly metabolized. 95% excreted in the form of metabolites in the urine for 24 hours. Activates the movement of melanocytes from the hair follicle into the epidermis, increases the sensitivity of the keratocyte DNA to the action of UV. It inhibits hyperproliferative processes in psoriasis.

Application of Methoxsalen

To increase the effectiveness of PUVA therapy: psoriasis, vitiligo, lichen planus, fungal mycosis.

Contraindications

Hypersensitivity (including other psoralens), blood diseases, malignant and benign tumors, melanoma (including history), hepatic and / or renal insufficiency, diabetes mellitus, increased photosensitivity (systemic lupus erythematosus, hepatoporphyria, pigment xeroderma, albinism), eye damage, aphakia, pregnancy, lactation, children and adolescence (up to 12 years).

Restrictions for use

Diseases of the liver, cardiovascular system.

pregnancy and lactation

Contraindicated in pregnancy.

The action category for fetus by FDA is C.

For the duration of treatment, breastfeeding should be discontinued.

Side effects of Methoxsalen

Dizziness, nausea, vomiting, decreased appetite, erythema, itching, burns (with excessive exposure to UV radiation), nervousness, insomnia, depression. With prolonged use in high doses: symptoms of skin aging, cataracts, skin cancer.

Interaction

(Mutually) photosensitizing effect (should not be administered together) anthralin, tar, and its derivatives, griseofulvin, phenothiazines, nalidixic acid, quinolones and fluoroquinolones, halogenated salicylanilides (bacteriostatic soaps), sulfonamides, tetracyclines, thiazides, organic dyes (methylene blue, toluidine blue, etc.).

Overdose

In case of intentional or accidental poisoning, it is necessary to induce vomiting (within the first 2-3 hours after administration), place the patient in a dark room (at least 24 hours).

Routes of administration

Inside.

Precautions for Methoxsalen

Do not take sunbaths 24 hours before taking methoxalen and subsequent phototherapy. After taking, it is recommended to wear sunglasses for 24 hours (to prevent the development of cataracts) and to avoid exposure to sunlight for 8 hours. During the irradiation session, the patient should be in sunglasses, only 1/3 of the prescribed dose of radiation should affect the skin of the stomach, breast, genitals.