Instruction for use: Interleukin-2 human recombinant

Trade name of the drug – Roncoleukinum

The Latin name of the substance Interleukin-2 human recombinant

Interleukinum-2 humanum recombinans (genus. Interleukini-2 humani recombinantis)

Pharmacological group:

Interleukins

The nosological classification (ICD-10)

A41.9 Septicemia, unspecified: Septic diseases; Septicemia / bacteremia; Toxico-infectious shock; Endotoxin shock; Bacterial septicemia; Bacterial infections of severe course; Generalized infections; Generalized systemic infections; Infections generalized; Wound sepsis; Septiccopymia; Septic-toxic complications; Septicemia; Septic conditions; Septic shock; Septic condition; Septic shock

C64 Malignant neoplasm of kidney, other than renal pelvis: Wilms tumor; Kidney Cancer; Metastatic Renal Cell Carcinoma; Renal carcinoma; Inoperable kidney carcinomas; Metastatic kidney carcinoma; Metastatic Renal Cell Carcinoma; Wilms tumor; Wilms swelling; Adenomyosarcoma; Adenomyocystosarcoma; Adenosarcoma of the kidney; Kidney Cancer; Common renal cell carcinoma; Nephroblastoma; Nephroma; Embryonal nephroma; Recurrent carcinoma of the kidney; Birch-Hirschfeld Tumor; Common renal cell carcinoma; Tumors of the kidney

D84.9 Unspecified Immunodeficiency: Pneumonia in immunodeficient states; Autoimmune disease; Autoimmune diseases; Severe immunodeficiency; immune deficiency; Immunodeficiency; immunodeficiency diseases; Immunodeficiency states due to surgery; Immunotherapy for cancer; Immunomodulation; Infections in patients with weakened immune systems; Correction of immune deficiency; Correction of immunodeficiencies; Correction of a weakened immune system; Correction of a weakened immunity in immunodeficient states; Violation of immunity; Violation of the immune status; Immune System Disorders; Primary immunodeficiency; Maintaining immunity; Lowering the body's defenses; Lowering the immunity; Lowering the immunity of colds and infectious diseases; The decrease of the immune status; Lowered resistance to infections; Lowered resistance to infections and colds; Lowered resistance; Immunosuppression; Predisposition to colds; acquired immune deficiencies; Radiation immunodeficiency; The development of immunodeficiency; Immune dysfunction syndrome; immunodeficiency syndrome; primary immunodeficiency syndrome; Reducing the body's defenses; Immunosuppression; Reduced immune defense; Reducing local immunity; Reducing the total body resistance; The decrease in cell-mediated immunity; Reduced resistance to infections in children; Reducing the body's resistance; Reduced resistance; reduced immunity; Status immunodeficiency; Stimulation of the processes of nonspecific immunity; Heavy selective secondary immunodeficiency; immunity Oppression; Primary immunodeficiency

O85 Postpartum sepsis: Postpartum infections; Pelvioperitonitis; Postpartum anaerobic sepsis; Puerperal fever

Characteristics of the substance Interleukin-2 human recombinant

Recombinant interleukin-2, obtained by biotechnological methods from producer cells-a recombinant strain of non-pathogenic bakery yeast Saccharomyces cerevisiae, whose genetic apparatus is embedded in the human interleukin-2 gene. It is a polypeptide consisting of 133 amino acids, is a structural and functional analogue of endogenous human interleukin-2.

Lyophilized powder or porous mass of white or white with a yellowish hue. Hygroscopic, easily soluble in isotonic sodium chloride solution.

Pharmacology

Mode action - Immunomodulating.

It binds to specific receptors on "target cells", stimulates the growth, differentiation and proliferation of T- and B-lymphocytes, monocytes, macrophages, oligodendroglial cells, Langerhans cells. Causes the formation of lymphokine-activated killers, activates tumor-filtering cells. Stimulates the cytolytic activity of natural killers and cytotoxic T-lymphocytes. Strengthens the immune response (antibacterial, antiviral, antifungal, antitumor).

Effective in the complex therapy of purulent-inflammatory and infectious diseases (peritonitis, pancreatitis, osteomyelitis, abscesses and phlegmon, tuberculosis, hepatitis C, yersiniosis, chlamydia, mycoses, etc.), in immunochemotherapy (melanoma, colorectal cancer, etc.), for prevention Secondary immunodeficiency (postoperative, against radiation, chemo- and hormone therapy).

Application of the substance Interleukin-2 human recombinant

Septic conditions accompanied by immunosuppression (sepsis post-traumatic, surgical, obstetric-gynecological, burn, wound, etc.) - as part of complex therapy; Malignant neoplasms, incl. Kidney cancer.

Contraindications

Hypersensitivity, incl. To yeast, autoimmune and severe cardiovascular diseases, pregnancy.

Application of pregnancy and breastfeeding

Contraindicated in pregnancy.

Side effects of the substance Interleukin-2 human recombinant

Grippopodobny syndrome (a short-term chill, an increase in body temperature).

Interaction

Compatible with other medicines.

Routes of administration

IV, drop, SC, intracavitary, topically.

Precautions for the substance Interleukin-2 human recombinant

Rapid IV administration may be accompanied by the development of cardiovascular failure.