Instruction for use: Insulin zinc suspension (crystalline) (Insulini cum Zinco (crystallisati) suspensio)

Pharmacological group

Insulins

Nosological classification (ICD-10)

E10 Insulin-dependent diabetes mellitus

Decompensation of carbohydrate metabolism, Diabetes mellitus, Diabetes insulin sugar, Diabetes mellitus type 1, Diabetic ketoacidosis, Insulin-dependent diabetes, Insulin-dependent diabetes mellitus, Coma hyperosmolar non-ketoacidotic, Labile form of diabetes mellitus, Violation of carbohydrate metabolism, Type 1 diabetes mellitus, Type I diabetes mellitus, Insulin-dependent diabetes mellitus, Type 1 diabetes mellitus

Pharmacology

Pharmacological action - hypoglycemic.

Regulates carbohydrate metabolism. It binds to a specific receptor of the plasma membrane, forms an insulin-receptor complex, which stimulates protein phosphorylation. It facilitates the penetration of glucose into cells and improves its absorption by tissues. Promotes the formation of glycogen, increases its reserves in muscles, activates synthesis and reduces the consumption of peptides, mobilizes fatty acids of adipose tissue. The action reaches its highest expression 1-2 hours after administration and lasts 10-16 hours.

Indications

Diabetes mellitus, symptomatic hyperglycemia.

Contraindications

Hypersensitivity, hypoglycemia, hyperglycemic coma, acute infectious diseases.

Side effects

Hypoglycemia, lipodystrophy, allergic reactions.

Interaction

Means for anesthesia, diazoxide, corticosteroids reduce the effect, oral antidiabetic drugs - strengthen.

Overdose

Symptoms: hypoglycemia up to coma.

Treatment: iv administration of 40% glucose solution.

Routes of administration

P / to or in / m (intramuscularly).

Precautions

In / in the introduction is unacceptable. It is not used for the treatment of hyperglycemic coma. Combined use with diuretics is undesirable. It is necessary to exclude the use of alcohol.