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Active substance Ketoprofen

ATX code M01AE03 Ketoprofen

Pharmacological group

NSAIDs - Propionic acid derivatives

Nosological classification (ICD-10)

G54.1 Disorders of lumbosacral plexus

Sciatica, Neurology radicular origin, spine Pathology, Sciatica lumbosacral, radiculoneuritis

I80 Phlebitis and thrombophlebitis

Diseases of peripheral vessels, Inflammation of superficial veins, Inflammatory diseases of veins, Deep venous thrombophlebitis, The disease of veins, Disease of the veins of the lower extremities, Diseases of peripheral vessels, Migrating phlebitis, Insufficiency of veins of lower extremities, Exacerbation of chronic thrombophlebitis, Acute thrombophlebitis,Acute thrombophlebitis of superficial veins, Periphlebitis, Periflebit surface, Superficial inflammation of veins, Surface thrombophlebitis, Surface phlebitis, Thrombophlebitis, Deep vein thrombophlebitis, Thrombophlebitis superficial, Phlebitis, Phlebitis of deep veins, Phlebitis of superficial veins, Phlebopathy, Chronic thrombophlebitis, Endophlebitis

I89.1 Lymphangitis

Lymphangitis, Lymphagitis, Lymphangitis acute

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism

M10 Gout

Exacerbation of gout, Acute articular attack with gout, Acute gouty attack, Gouty attack, Recurrent gout attacks, Chronic gout

M25.5 Pain in the joint

Arthralgia, Pain syndrome in musculo-articular diseases, Pain syndrome in osteoarthritis, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the joints, Soreness of the joints, Soreness of joints in severe physical exertion, Painful inflammatory joint damage, Painful conditions of the musculoskeletal system, Painful joint conditions, Painful traumatic affection of joints, Pain in the musculoskeletal system, Pain in Shoulder Joints, Pain in the joints, Joint pain, Joint pain with injuries, Musculoskeletal pain, Pain with osteoarthritis, Pain in the pathology of the joints, Pain in rheumatoid arthritis, Pain in chronic degenerative bone diseases, Pain in chronic degenerative joint diseases, Bone-joint pain, Joint pain, Arthritic pain of rheumatic origin, Articular pain syndrome, Joint pain, Rheumatic pain, Rheumatic pains

M35.3 Rheumatic polymyalgia

Pseudoarthritis rhizomelic, Rheumatic polymyalgia, Pain syndrome in rheumatic diseases, Muscle pain with rheumatism, Extra-articular rheumatism, Extra-articular rheumatic syndrome, Extra-articular rheumatic diseases, Extra-articular rheumatic soft tissue injury, Extra-articular forms of rheumatism, Rheumatic soft tissue damage, Rheumatism of soft tissues, Rheumatic diseases of soft tissues, Rheumatic diseases of the periarticular soft tissues, Rheumatic affections of soft tissues, Rheumatic collagen diseases

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

M54 Dorsalgia

Pain in the back area, Pain in the spine, Back pain, Pain in different parts of the spine, Backache, Painful pain syndrome in the spine, Pain in the musculoskeletal system

M54.3 Sciatica

Ishialgia, Neuralgia of the sciatic nerve, Sciatic neuritis

M65 Synovitis and tendosynovitis

Acute tenosynovitis, Tendovaginitis (tenovaginitis), Tendosinovit (tenosynovitis), Tendovaginitis, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Nonspecific tenosynovitis, Tendosinovit

M71 Other bursopathies

Bursitis, Bursopathy, Diseases of soft tissues, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Subacute bursitis

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

M79.1 Myalgia

Myofascial pain syndromes ,Pain syndrome in musculo-articular diseases, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the muscles, Tenderness of muscles, Muscular soreness in severe physical exertion, Painful conditions of the musculoskeletal system, Pain in the musculoskeletal system, Pain in the muscles, Pain at rest, Muscle aches, Muscle pain, Musculoskeletal pain, Myalgia, Muscle pain, Muscle pain at rest, Muscle pain, Muscular pain of non-rheumatic origin, Muscle pain of rheumatic origin, Acute muscle pain, Rheumatic pain, Rheumatic pains, Myofascial syndrome, Fibromyalgia

R52.2 Other constant pain

Pain syndrome, rheumatic origin, Pain at vertebral lesions, Pain in the chamber, Pain for burns, Pain syndrome weak or moderate, Perioperative pain,Moderate to severe pain, Moderately or weakly expressed pain syndrome, Moderate to severe pain, Ear pain of otitis, Neuropathic pain, neuropathic pain

T14.3 Dislocation, sprain and damage to the capsular-ligamentous apparatus of the joint of the unspecified area of the body

Painful stretching of muscles, Pain and inflammation in tension, Dislocation of dislocation, Degenerative changes in the ligamentous apparatus, Edema due to sprains and bruises, Edema after interventions for sprains, Damage and rupture of ligaments, The musculoskeletal system is damaged, Damage to ligaments, Damage to the joints, Ligament ruptures, Tendon tendons,Ruptures of the tendons of muscles,Stretching, Crick, Stretching of the muscle, Sprain, Tension of the tendons, Extensions,Stretch muscles, Sprains, Tension of the tendons, Injury of the musculoskeletal system, Injuries to the joints, Injuries of capsule-articular tissues, Injuries of the osteoarticular system, Injuries to ligamentsInjuries to the joints, Joint wounds, Stretching of the ligamentous apparatus, Habitual stretching and tearing

Composition and form of release

1 soft gelatin capsule contains ketoprofen 50 mg; in blistere 10 pcs., in a cardboard bundle 3 blisters.

1 suppository rectal - 100 mg; in a strip of 6 pcs., in a cardboard bundle 2 strips.

100 g of gel - 2.5 g; in tubes of 30 or 50 grams, in a cardboard bundle 1 tube.

1 ampoule with lyophilized powder for solution for injection - 100 mg, complete with a solvent in ampoules; in a cardboard bundle of 6 sets.

pharmachologic effect

Pharmacological action - anti-inflammatory, analgesic.

It inhibits cyclooxygenase and inhibits the synthesis of PG.


Inflammatory diseases of the musculoskeletal system: osteoarthritis, ankylosing spondylitis, gout, rheumatoid arthritis, bursitis, tendosinovitis, sciatica, myalgia, sciatica, bruises and strains of muscles, tendons and ligaments, edema (symptomatic therapy); pain syndrome (postoperative, post-traumatic pain, bone metastases), renal colic, algodismenorea.

Solution for injection - acute pain syndrome.


Hypersensitivity (including to other NSAIDs), gastrointestinal diseases in the acute phase, severe renal and hepatic dysfunction, leukopenia, thrombocytopenia, bleeding disorders, hemorrhoids and proctitis (suppositories), pregnancy, breast-feeding, children under 15 years of age .

pregnancy and lactation

Contraindicated. For the duration of treatment, breastfeeding should be discontinued.

Side effects

From the nervous system and sensory organs: dizziness, headache, asthenia.

On the part of the intestine: gastralgia, nausea, vomiting, diarrhea, flatulence, gastrointestinal hemorrhages.

Other: transient dysuria, skin allergic reactions (pruritus, urticaria), with the use of suppositories - burning sensation, tenesmus, liquid stool.

Dosing and Administration

Capsules: Inside, after eating, without chewing and drinking with a sufficient amount of water, 50-100 mg 2-3 times a day.

Suppositories: rectally, 1 supp. (100 mg) 1-2 times a day.

Gel: topically, apply a small amount of gel a thin layer on the skin above the inflammation focus and lightly rub 2-3 times a day. Duration of treatment should not exceed 14 days without consulting a doctor.

Injection: deep into the muscle 100 mg 1-2 times a day for usually a few days. After the removal of acute pain syndrome, they switch to the use of capsules or suppositories.

The maximum daily dose is 300 mg.

Precautionary measures

With caution appoint patients with violations of the liver and / or kidney function, gastrointestinal disease in history, bronchial asthma, rhinitis, urticaria, polyps of the nasal mucosa, heart failure and the elderly.

Avoid contact with the gel on the damaged skin, open wounds, eyes and other mucous membranes.

storage Conditions

At a temperature of no higher than 25 C.

Keep out of the reach of children.

Shelf life

lyophilizate for the preparation of solution for intramuscular injection 100 mg - 3 years.

suppositories rectal 100 mg - 3 years.

gel for external use 2.5% - 3 years.

capsules 50 mg - 5 years.

Do not use after the expiry date printed on the package.

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