Instruction for use: Ferrous fumarate

Trade name of the drug – Ferous fumarate, Ferrous fumarate 200, Ferronat, Heferol

The Latin name of the substance Ferrous fumarate

Ferri fumaras (genus. Ferri fumaratis)

Chemical name

Iron (II) butenedioate salt (1: 1)

Gross formula

C4H2FeO4

Pharmacological groups:

Macro and microelements

Stimulators of hematopoiesis

The nosological classification (ICD-10)

D50.0 Iron deficiency anemia secondary due to loss of blood (chronic): Anemia posthemorrhagic; Anemia in chronic hemorrhage; Chronic blood loss in the digestive tract; Posthemorrhagic anemia

D50.9 Iron deficiency anemia, unspecified: Iron deficiency anemia; Lack of iron in food; Insufficient absorption of iron from the gastrointestinal tract; Insufficient food intake of iron; Hypochromic iron deficiency anemia; Hypochromic anemia; Iron deficiency anemia in pregnant women; Iron deficiency; Disturbance of absorption of iron from the digestive tract; Combined iron-folic-B12-deficient anemia; Anemia due to violations of hemoglobin synthesis and iron metabolism; Anemia in disorders of iron utilization and reutilization; Impaired iron absorption; Impaired absorption of iron; Insufficient absorption of iron in the digestive tract

E61.1 Insufficiency of iron: Insufficient food intake of iron; Iron deficiency; Iron deficiency in women during pregnancy; Deficiency of iron and folic acid in pregnancy; Iron deficiency after surgery; Latent iron deficiency; Lack of iron during pregnancy and lactation; Inadequate intake of iron from food; Increased need for iron; Increased need for iron during menstruation; Disturbances of iron absorption from the digestive tract; Severe iron deficiency

CAS code

141-01-5

Pharmacology

Mode action - Hematopoietic, antianemic, erythropoietic.

Replenishes the body's iron deficiency, necessary for the synthesis of hemoglobin and other globin enzymes.

It is characterized by high bioavailability, since divalent iron (ferrous) is easily absorbed, and fumaric acid enhances its absorption. Cmax is achieved 4 hours after admission. T1 / 2 - about 12 hours. In iron deficiency anemia, taking 350 mg once a day provides the minimum effective dose of iron. In this case, the level of hemoglobin (and iron) in the blood serum increases, the number of red blood cells increases; All hematological and clinical symptoms of anemia regress after 3-4 weeks of treatment.

Application of the substance Ferrous fumarate

Iron deficiency anemia: posthemorrhagic (menorrhagia, chronic blood loss in the gastrointestinal tract, etc.); Increased need for iron (pregnancy, lactation, a period of intensive growth and puberty, especially in girls) - treatment and prevention; Inadequate intake of iron from food or a violation of its absorption (chronic diarrhea, helminthic invasion); Iron-deficiency anemia in elderly and elderly people (as a trial treatment).

Contraindications

Hemolytic (hereditary and acquired) and other anemia, not associated with iron deficiency, hemochromatosis, stomach and duodenal ulcer in the exacerbation phase, inflammatory bowel disease (Crohn's disease, ulcerative colitis).

Side effects of the substance Ferrous fumarate

Anorexia, metallic taste in the mouth, nausea, vomiting, obstipation, diarrhea.

Interaction

Violates (mutually) the absorption of antibiotics of the tetracycline series. Almagel and magnesium salts impair absorption from the intestine.

Overdose

Symptoms: nausea, epigastric pain, vomiting with blood, diarrhea, dizziness, weakness, confusion, acrocyanosis, lowering blood pressure, weak pulse.

Treatment: stimulation of vomiting, gastric lavage (at an early stage), administration of milk with egg white; Carrying out a specific (prescription inside and parenterally deferoxamine) and symptomatic therapy.

Routes of administration

Inside.

Precautions for the substance Ferrous fumarate

Regular monitoring of hematological parameters is necessary: a sign of the effectiveness of treatment is an increase in the number of reticulocytes on the 7th-10th day from the beginning and normalization of the hemoglobin level in 3-4 (sometimes 6-8) weeks. If the tolerance is poor, the dose reduction, taking the drug during meals, as well as a short break in treatment are indicated.