Instruction for use: Epoetin alfaI want this, give me price
Trade name of the drug – Aeprine, Binokrit, Repoetinum SP, Epocrin, Eprex, Erythropoetin alpha human recombinant
The Latin name of the substance Epoetin alfa
Epoetinum alfa (genus. Epoetini alfa)
Alpha- (1-165) -Erythropoietin (genetically engineered); A glycoprotein consisting of 165 amino acids
Stimulators of hematopoiesis
The nosological classification (ICD-10)
C90 Multiple myeloma and malignant plasma cell neoplasms: Retikuloplasmocytosis; Rustitsky's disease; Rustitskogo-Kahler's disease; Plasma cell myeloma; Myelomatosis
C91 Lymphoid leukemia [lymphatic leukemia]: Lymphatic leukemia; Lymphoproliferative diseases; Neuroleukemia; Refractory acute lymphoblastic leukemia; Refractory lymphoblastic leukemia; Transformation of preleukemias; Chronic lymphocytic leukemia; Lymphoproliferative disorders
D63.0 Anemia in neoplasm: Anemia in chronic diseases; Anemia due to radiation damage; Radiation anemia; Anemia in patients with solid tumors; Pernicious anemia
D63.8 Anemia in other chronic diseases classified elsewhere: Anemia in chronic diseases; Anemia in immunological disorders; Anemia in peptic ulcer; Anemia in kidney diseases; Anemia with HIV treatment; Anemia in the background of chronic renal failure; Anemia in patients with myeloma; Symptomatic anemia; Symptomatic anemia of renal genesis; Anemia in HIV-infected patients; Renal anemia
Mode action - Antianemic, erythropoietic.
Stimulates mitosis and differentiation of erythroid progenitor cells. Increases the number of erythrocytes, reticulocytes, hemoglobin content, improves heart function and blood supply to tissues.
Bioavailability after SC administration is 25%, Cmax is reached after 12-18 hours; T1 / 2 up to 24 hours after SC administration; With iv injection T1 / 2 is 5-6 hours, with periodic injections in the blood does not cumulate.
Application of the substance Epoetin alfa
Anemia: with chronic renal failure, hemodialysis, HIV infection against zidovudine, cytostatic chemotherapy, in preterm infants; Preparation of patients with anemia for surgery with the expected massive blood loss.
Hypersensitivity, uncontrolled arterial hypertension, iron deficiency, pregnancy, breast-feeding.
Application of pregnancy and breastfeeding
The action category for fetus by FDA is C.
Side effects of the substance Epoetin alfa
Hypertension, headache, fatigue, asthenia, dizziness, arthralgia, retrosternal pain, nausea, vomiting, diarrhea, swelling, thrombophilia, seizures, skin reactions at the injection site.
Symptoms: polycythemia and hematocrit change. Special treatment is required - temporarily cancel epoetin (before the normalization of hematocrit).
Routes of administration
SC or IV.
Precautions for the substance Epoetin alfa
Do not use in combination with solutions of other medicines. It is necessary to regularly monitor the hematocrit to prevent a decrease in effectiveness and development of resistance. It is recommended to use plastic syringes and containers, avoid glass.