Instruction for use: Dobutrex

Active substance Dobutamine

ATX Code C01CA07 dobutamine

Pharmacotherapeutic group:

Cardiac glycosides and not glycosides cardiac agents

Beta-adrenergic agonist

Structure and Composition

1 vial of lyophilized powder for infusion comprising 250 mg of dobutamine (hydrochloride).

pharmachologic effect

pharmachological effect

cardiotonic.

It stimulates the adrenergic receptors of myocardium.

pharmacodynamics

Provides direct inotropic effect, increases the stroke and minute volume, decreases ventricular filling pressure, the total systemic and pulmonary vascular resistance.

Indications

Acute heart failure, cardiogenic (acute myocardial infarction, cardiogenic shock, the effects of heart surgery, the use of drugs that reduce myocardial contractility) and noncardiogenic (acute vascular insufficiency in trauma, surgery, sepsis, hypovolemia, when mean arterial pressure above 70 mmHg, low cardiac output during mechanical ventilation) genesis, chronic congestive heart failure, coronary artery disease diagnosis, as a substitute for exercise.

Contraindications

Hypersensitivity.

Pregnancy and breast-feeding

During pregnancy and lactation appoint only for health reasons (if a beneficial effect outweighs the potential risk to the fetus and the baby to the mother).

Side effects

Increased heart rate, increased blood pressure, ventricular arrythmia, hypotension, nausea, headache, non-specific chest pain, shortness of breath, hypokalemia, phlebitis.

Interaction

Beta-blockers reduce cardiotropic effect, but increase the severity of alpha1-adrenostimuliruyuschee properties (vasoconstriction, increased blood pressure). Alpha-blockers increase beta-Adrenomimeticalkie properties (tachycardia, vasodilation).

Dosing and Administration

B / drip rate from 2.5-20 ug / kg / min (in rare cases, the infusion rate was increased to 40 ug / kg / min). The rate and duration of administration set individually, taking into account the patient's response and reactions hemodynamic parameters (heart rate, blood pressure, heart rate), and diuresis, body temperature, and mental status.

Precautionary measures

At the beginning of therapy should be monitored ECG.

Storage conditions

At a temperature of 15-30 ° C.

Keep out of the reach of children.

The shelf life

4,5 years.

Do not use beyond the expiration date printed on the package.