Instruction for use: Dobutamin HEXAL

Active substance Dobutamine

ATX Code C01CA07 dobutamine

Pharmacotherapeutic group:

Cardiac structure neglikozidnye [Cardiac glycosides and cardiac neglikozidnye means]

Cardiac neglikozidnye structure of [beta-adrenergic agonist]

The nosological classification (ICD-10)

I50 Heart failure

Exacerbation of chronic heart failure, Shortness of breath with acute heart failure, Acute heart failure, Acute heart failure, Heart failure on the background of intoxication, Heart failure on the background of infections, Acute Heart Failure, Chronic myocardial insufficiency, Cardiac dyspnea

I50.0 Congestive heart failure

anasarca heart, Decompensated congestive heart failure, Congestive heart failure, Congestive heart failure with high afterload, Congestive chronic heart failure, Cardiomyopathy with severe chronic heart failure, Compensated chronic heart failure, Swelling with circulatory failure, Edema of cardiac origin, Swelling of the heart, Edematous syndrome in diseases of the heart, Edematous syndrome in congestive heart failure, Edematous syndrome in heart failure, Edematous syndrome in heart failure or liver cirrhosis, right ventricular failure, Congestive Heart Failure, Heart failure stagnant, Heart failure with low cardiac output, Heart failure is a chronic, Cardiac edema, Chronic decompensated heart failure, Chronic Congestive Heart Failure, Chronic heart failure, Change of liver function in heart failure

Z100 * CLASS XXII Surgical practice

Abdominal surgery, adenomectomy, Amputation, Coronary angioplasty, Angioplasty of the carotid arteries, Antiseptic skin treatment for wounds, Antiseptic Hand, Appendectomy, atherectomy, Balloon coronary angioplasty, Vaginal hysterectomy, The coronary bypass, Interventions in the vagina and cervix, Interventions on the bladder, Intervention in the mouth, Restoration and reconstructive surgery, Hand hygiene of medical personnel, Gynecologic surgery, Gynecological intervention, Gynecological surgery, Hypovolemic shock during operations, Disinfection of purulent wounds, Disinfection of wounds edges, Diagnostic intervention, Diagnostic procedures, Cervical Diathermocoagulation, Long-surgery, Replacing the fistula catheters, Infection in orthopedic surgery, Artificial heart valve, cystectomy, Short-term outpatient surgery, Short-term operation, Short surgical procedures, Krikotireotomiya, Blood loss during surgery, Bleeding during surgery and in the postoperative period, Kuldotsentez, laser photocoagulation, laser coagulation, retinal laser coagulation, Laparoscopy, Laparoscopy in Gynecology, CSF fistula, Small gynecological operations, Small surgical procedures, Mastectomy and subsequent plastic, mediastinotomy, Microsurgical operations on the ear, Mukogingivalnye operation, suturing, Minor surgery, neurosurgical operation, Immobilization of the eyeball in ophthalmic surgery, testectomy, pancreatectomy, Perikardektomiya, The period of rehabilitation after surgery, The period of, convalescence after surgery, Percutaneous transluminal coronary angioplasty, Pleural thoracentesis, Pneumonia postoperative and posttraumatic, Preparation for surgical procedures, Preparation for surgery, Preparation of the surgeon's hands before surgery, Preparation of the colon for surgical procedures, Postoperative aspiration pneumonia in neurosurgical and thoracic surgery, Postoperative nausea, Postoperative bleeding, postoperative granuloma, postoperative shock, The early postoperative period, myocardial revascularization, Radiectomy, gastric Resection, bowel resection, uterine Resection, liver Resection, enterectomy, Resection of part of the stomach, Reocclusion of the operated vessel, Bonding tissues during surgical procedures, Removal of sutures, Condition after eye surgery, Condition after surgery, Condition after surgery in the nasal cavity, Condition after gastrectomy, Status after resection of the small intestine, Condition after tonsillectomy, Condition after removal of the duodenum, Condition after phlebectomy, Vascular surgery, Splenectomy, Sterilization of surgical instruments, Sterilization of surgical instruments, sternotomy, Dental surgery, Dental intervention in periodontal tissues, strumectomy, Tonsillectomy, Thoracic surgery, total gastrectomy, Transdermal intravascular coronary angioplasty, Transurethral resection, Turbinektomiya, Removal of a tooth, cataract surgery, Removal of cysts, tonsillectomy, Removal of fibroids, Removing the mobile primary teeth, Removing polyps, Removing broken tooth, Removal of the uterus body, Removal of sutures, Urethrotomy, Fistula likvoroprovodyaschih ways, Frontoetmoidogaymorotomiya, Surgical infection, Surgical treatment of chronic limb ulcersm, Surgery, The surgery in the anal area, The surgery on the colon, Surgical practice, The surgical procedure, Surgical interventions, Surgery on the gastrointestinal tract, Surgical procedures on the urinary tract, Surgical procedures on the urinary system, Surgical intervention of the genitourinary system, Surgical procedures on the heart, Surgical manipulation, surgery, Surgery on the veins, Surgical intervention, Vascular surgery, Surgical treatment of thrombosis, cholecystectomy, Partial gastric resection, transabdominal hysterectomy, Percutaneous transluminal coronary angioplasty, Percutaneous transluminal angioplasty, Coronary artery bypass, tooth Extirpation, Extirpation of milk teeth, pulpectomy, pulsative cardiopulmonary bypass, tooth Extraction, teeth Extraction, cataract extraction, Electrocoagulation, endourological intervention, episiotomy, Etmoidotomiya, Complications after tooth extraction

Structure and Composition

lyophilisates for solution for infusion 1 vial.

active substance:

dobutamine hydrochloride 280 mg

(Equivalent to 250 mg dobutamine)

Excipients: mannitol

pharmachologic effect

pharmachological effect

cardiotonic.

Dosing and Administration

in the form of infusion.

Dobutamine hexane is intended only for the on / in infusions after preliminary breeding. The speed and duration of administration of dobutamine hexane set individually, taking into account the reaction of the patient, and the dynamics of hemodynamic parameters.

Dobutamine hexane lyophilizate for solution for infusion, initially diluted in 10 ml sterile water for injection, if the drug is not completely dissolved, add an additional 10 ml.

If necessary further dilution dobutamine concentrate, use of 5% glucose solution, 0.9% sodium chloride solution, Ringer's solution or lactate sodium solution.

The diluted solution can be stored for 24 hours, after which it was not applicable.

Solutions containing dobutamine infusion may produce a pink color, the intensity of which will increase with time (as a result of oxidation, but significant loss of activity and increase the toxicity does not occur). Prepared solutions are not suitable for multiple drug selection. Because of the small half-life should be dobutamine prolonged continuous infusion.

Duration / v infusion depends on the results of clinical efficacy. During the administration of dobutamine hexane requires constant monitoring of heart rate, heart rate, blood pressure values, the number of allocated urine and infusion rate. If possible, during the treatment should also follow the size of cardiac output, central venous pressure and pulmonary capillary pressure.

If no other assignments should enter adults in doses of dobutamine hexane 2.5-10 mg / kg / min. In some cases, the dosage is 40 ug / kg / min of dobutamine.

Children are encouraged to enter dobutamine in doses of 1 to 15 mcg / kg / min. At doses greater than or equal to 7.5 ug / kg / min beginning to emerge most side effects (especially tachycardia). There is evidence that the minimum effective dose in children is higher than in adults. Simultaneously, the maximum tolerated dose in infancy is lower than in adults. Achieving the necessary dosages in children should be performed cautiously because of, presumably, the lower therapeutic breadth in childhood!

release Form

Valium for solution for infusion 250 mg. At 530 mg in a glass bottle with a capacity of 20 ml of neutral glass, closed with a rubber stopper, a metal cap and a plastic cover; 1 fl. placed in a wad

Storage conditions

In the dark place at a temperature no higher than 25 ° C. The mixed solution at a temperature of 2-8 ° C - 24 hours at room temperature, - 6 hours.

Keep out of the reach of children.

The shelf life

3 years.

Do not use beyond the expiration date printed on the package.

Available on prescription