Instruction for use: Diphteria anatoxin

Trade name of the drug – Anatoxinum diphthericum purificatum adsorptum cum quantitate minore antigenori fluidum, Anatoxin diphtheria purified concentrated liquid

The Latin name of the substance Diphteria anatoxin

Anatoxinum diphtericum (genus. Anatoxini diphterici)

Pharmacological group:

Vaccines, serums, phages and toxoids

Model clinical-pharmacological article 1

Characteristic. Sorbed on aluminum hydroxide.

Pharmacotherapy. Forms specific immunity against diphtheria.

Indication. Prevention of diphtheria in children from 6 years of age, adolescents and adults.

Contraindications. Hypersensitivity.

Dosing. IM in the upper outer quadrant of the buttocks or the antero-external part of the thigh or deep in the penis (adolescents and adults) in the subscapular region in a single dose of 0.5 ml. Before vaccination, the ampoule must be shaken thoroughly until a homogeneous suspension is obtained.

For scheduled age-specific revaccinations, individuals who received a tetanus toxoid vaccine because of emergency tetanus prophylaxis receive the drug once.

Side effect. Rarely (in the first 2 days) - hyperthermia, malaise, local reactions (soreness, congestion, swelling); In isolated cases - allergic reactions (angioedema, urticaria, polymorphic rash), a slight exacerbation of allergic diseases.

Special instructions. Persons who have had acute illnesses are vaccinated 2-4 weeks after recovery. For mild forms of disease, vaccinations are allowed after the disappearance of clinical symptoms.

Patients with chronic diseases are vaccinated after achieving complete or partial remission. Persons with neurological changes are vaccinated after excluding the progression of the process. Patients with allergic diseases are vaccinated after 2-4 weeks after the end of exacerbation, while stable manifestations of the disease (localized skin conditions, hidden bronchospasm, etc.) are not contraindications to vaccination, which can be performed against the background of appropriate therapy.

Immunodeficiencies, HIV infection, as well as supporting course therapy (including SCS and neurotropic drugs) are not contraindications to vaccination.

Pregnant vaccinations are carried out according to epidemiological indications.

In order to identify contraindications, the doctor on the day of vaccination is interviewing parents and examining the vaccinated with mandatory thermometry. When vaccinating adults, preliminary selection of persons to be vaccinated is possible with their interview by a medical worker on the day of vaccination that conducts the vaccination. Persons temporarily released from vaccination should be monitored and accounted for and promptly vaccinated. With epidemiological necessity, the drug can be injected against the background of an acute disease.

In the case of a strong reaction to the previous dose of this drug, a second dose is given against the background of the use of GCS (prednisolone 1-1.5 mg / kg / day a day before and immediately after vaccination).

The drug can be administered after a month or simultaneously with poliomyelitis vaccine and other drugs of the national vaccination calendar.

Given the possibility of developing allergic reactions of immediate type in particularly sensitive individuals, vaccinated patients should be provided with medical supervision for 30 minutes. Places of vaccination should be provided with anti-shock therapy.

Persons who gave severe forms of allergic reactions for administration of the drug, further scheduled vaccinations of the drug are discontinued.

The drug is not suitable for use in ampoules with broken integrity, lack of marking, changing physical properties (discoloration, presence of non-breakable flakes), improper storage.

Opening of ampoules and the vaccination procedure are carried out with strict adherence to aseptic and antiseptic rules. The drug in the opened ampoule is not subject to storage.

The preparation of the drug is registered in the established registration forms with the indication of the serial number, expiration date, manufacturer's company, date of introduction.