Instruction for use: Dimethylsulfoxide (Dimethylsulfoxydum)

Pharmacological group

dermotropic means

Nosological classification (ICD-10)

A46 erysipelas

Erysipelas

I80 Phlebitis and thrombophlebitis

Diseases of peripheral vessels, Inflammation of superficial veins, Inflammatory diseases of veins, Deep venous thrombophlebitis, The disease of veins, Disease of the veins of the lower extremities, Diseases of peripheral vessels, Migrating phlebitis, Insufficiency of veins of lower extremities, Exacerbation of chronic thrombophlebitis, Acute thrombophlebitis,Acute thrombophlebitis of superficial veins, Periphlebitis, Periflebit surface, Superficial inflammation of veins, Surface thrombophlebitis, Surface phlebitis, Thrombophlebitis, Deep vein thrombophlebitis, Thrombophlebitis superficial, Phlebitis, Phlebitis of deep veins, Phlebitis of superficial veins, Phlebopathy, Chronic thrombophlebitis, Endophlebitis

K04.0 Pulpit

K05 Gingivitis and periodontal disease

Gingivitis, Inflammatory Gum Disease, Inflammatory diseases of the oral cavity, Hyperplastic gingivitis, Diseases of the mouth, Catarrhal gingivitis, Erythematous gingivitis, Ulcerative gingivitis, Exacerbation of inflammatory diseases of the pharynx and oral cavity, Bleeding from the gums, Epstein cysts

K05.3 Chronic periodontitis

Periodontitis chronic, Periodontitis, Infections of periodontal disease

K07.6 Diseases of the temporomandibular joint

Temporomandibular joint syndrome

K10.2 Inflammatory diseases of the jaws

Infections of maxillofacial area, Purulent-inflammatory processes of maxillofacial area

K11.9 Disease of salivary gland, unspecified

L02 Skin abscess, furuncle and carbuncle

Furuncle of external auditory canal, Furuncle of the auricle, Furuncles, Abscess, Abscess of skin, Carbuncle, Carbuncle skin, Furuncle, Skin furuncle, Furunculosis, Chronic recurrent furunculosis

L08.0 Pyoderma

Festering atheroma, Pustular dermatoses, Pustular skin lesions, Purulent allergic dermatopathies, Purulent skin infections, Infected atheroma, Mycosis complicated by secondary pyoderma, Ostiophalliculitis, Piodermatitis, Pyoderma ,Superficial pyoderma, Sycosis of Staphylococcus aureus, Staphyloderma, Streptodermia, Streptophiloderma, Chronic pyoderma

L30.9 Dermatitis, unspecified

Allergic dermatoses complicated by a secondary bacterial infection, Anal eczema, Bacterial maturation, Varicose Eczema, Venous dermatitis, Inflammation of the skin, Inflammation of the skin upon contact with plants, Inflammatory Skin Diseases, Inflammatory skin reactions, Inflammatory processes of the skin, Hypostatic dermatitis, Fungal Eczema, Fungal dermatosis, Dermatitis, Dermatitis is stagnant, Dermatitis and eczema in the anal area, Dermatitis acute contact, Perianal dermatitis, Dermatosis, Dermatosis of the scalp, Dermatosis of psoriasis, Dermatosis with persistent itching, Dermatoses, Dermatoses itchy, Other itching dermatoses, Significant eczematous manifestations, Itching with, dermatoses, Itching eczema, True eczema, Skin reaction to insect bites,Skin itching with dermatosis, Constitutional eczema, Weeping eczema, Drowsing inflammatory skin disease, Dying Infectious-Inflammatory Skin Disease, Non-allergic dermatitis, Nummular eczema, Acute contact eczema, Acute inflammatory skin disease, Acute dermatosis, Acute severe dermatosis, Perianal dermatitis, Superficial dermatosis, Subacute Contact Eczema, Simple dermatitis, Occupational dermatitis, Psychogenic dermatosis, Bubble dermatitis of newborns, Pustular eruptions, Irritation and redness of the skin, Low-flammable eczema, Dry atrophic eczema, Dry eczema, Toxic dermatitis, Ear eczema like dermatitis, Chronic eczema, Chronic dermatosis, Chronic common dermatosis, Scaly papular dermatosis, Eczema, Eczema anal region, Eczema of the hands, Eczema Contact, Eczema lichenized, Eczema Nummular, Eczema acute, Eczema acute contact, Eczema subacute, Eczematous dermatitis, Eczema-like rashes, Ecome exogenous, Endogenous eczema, Gluteal dermatitis, Restricted itchy dermatitis

L52 Erythema nodosum

Nodal erythema, Erythema nodosa, Leprosy erythema nodosum

L70 Acne

Acne nodulocystica, Acne, Comedone acne, Acne Treatment, Papulous pustular acne, Papulopustulicular acne, Papulo-pustular acne, Acne, Acne Disease, Acne, Acne vulgaris, Nodular-cystic acne, Nodular-cystic acne

L93.0 Discoid lupus erythematosus

Chronic discoid lupus erythematosus, Red discoid lupus, Discoid lupus, Discoid erythematosis

L98.4.2 * Trophic skin ulcer

Varicose ulcer, Varicose ulcers, Cutaneous ulcer, Non-healing ulcers, Trophic ulcer, Trophic ulcer of lower leg, Trophic skin lesions, Trophic after-burn ulcers, Trophic ulcers, Trophic skin ulcers, Ulcer of lower leg, Ulcer of skin, Ulcer of trophic skin, Ulcer on legs, Ulcerative necrosis of the skin, Ulcer of shin, Ulcer of the lower leg, Ulcers of lower extremities, Difficult healing ulcers

L98.6 Other infiltrative diseases of the skin and subcutaneous tissue

Dermopathy infiltrative ,Inflammatory infiltrates

M06.9 Other specified rheumatoid arthritis

Rheumatoid arthritis,Pain syndrome in rheumatic diseases, Pain in rheumatoid arthritis, Inflammation in rheumatoid arthritis, Degenerative forms of rheumatoid arthritis, Children's rheumatoid arthritis, Exacerbation of rheumatoid arthritis, Acute articular rheumatism, Rheumatic arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatic polyarthritis, Rheumatoid arthritis, Rheumatoid arthritis of active course, Rheumatoid arthritis, Rheumatoid polyarthritis, Acute rheumatoid arthritis, Acute rheumatism

M19.9 Arthrosis, unspecified

Change in brush with osteoarthritis, Osteoarthritis, Osteoarthrosis, Arthrosis of large joints, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Deforming arthrosis, Deforming osteoarthritis, Deforming osteoarthritis of joints, Osteoarthritis in the acute stage, Osteoarthritis of large joints, Acute pain syndrome with osteoarthritis, Post-traumatic osteoarthritis, Rheumatic osteoarthritis, Spondylarthrosis, Chronic osteoarthritis

M34.9 Systemic sclerosis, unspecified

Systemic scleroderma

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

M54.1 Radiculopathy

Acute sciatica, Radiculopathy, Radiculitis, Radiculitis with radicular syndrome, Acute radiculopathy, Pain syndrome with radiculitis, Subacute radiculitis, Radiculitis, Chronic radiculitis, Diseases of the spinal column

M65.9 Synovitis and tendosynovitis, unspecified

Synovitis, Inflammation of the tendon sheath, Acute nonspecific tenosynovitis, Reactive synovitis

R60.9 Edema, unspecified

Dropsy of joints, Inflammatory swelling of soft tissues, Dysprostainemic edema, Fluid retention in the body, Fluid retention for obesity, Edema, Hypothyroid edema, Edema of renal genesis, Osteoarthritis in musculo-articular diseases, Increased accumulation of fluid in the tissues of the body, Swelling of high-altitude

T14.0 Surface injury of unspecified body region

Abrasions, Scratch, Skin Wounds, Wounds of soft tissues, Hematoma, Hematoma of traumatic origin, Hematomas, Hematomas of muscles, Hematomas of soft tissues, Healing of the skin, Bruise, Bruising due to sprains and bruises, Microtrauma, External bruises, Small combing, Superficial hematoma, Superficial damage to the skin and mucous membranes, Subcutaneous hematoma, Post-traumatic hematoma, Post-traumatic disturbance of microcirculation, Skinness of the skin, Traumatic plexus lesions, Injury, Contusion of soft tissues, Joint bruise, Traumatic bruises, Traumatic injury, Primary treatment of surface contaminated wounds, Abrasion, Bruise

T14.3 Dislocation, sprain and damage to the capsular-ligamentous apparatus of the joint of the unspecified area of the body

Painful stretching of muscles, Pain and inflammation in tension, Dislocation of dislocation, Degenerative changes in the ligamentous apparatus, Edema due to sprains and bruises, Edema after interventions for sprains, Damage and rupture of ligaments, The musculoskeletal system is damaged, Damage to ligaments, Damage to the joints, Ligament ruptures, Tendon tendons,Ruptures of the tendons of muscles,Stretching, Crick, Stretching of the muscle, Sprain, Tension of the tendons, Extensions,Stretch muscles, Sprains, Tension of the tendons, Injury of the musculoskeletal system, Injuries to the joints, Injuries of capsule-articular tissues, Injuries of the osteoarticular system, Injuries to ligamentsInjuries to the joints, Joint wounds, Stretching of the ligamentous apparatus, Habitual stretching and tearing

T30 Thermal and chemical burns, unspecified

Pain syndrome with burns, Pain in burns, Pain with burns, Sluggishly healing post-burn wounds, Deep burns with a wet scab, Deep burns with abundant compartments, Deep burn, Laser burn, Burn, Burn of rectum and perineum, Burn with mild exudation, Burn disease, Burn injury, Superficial burn, Superficial burn of I and II degree, Superficial skin burns, After-burn trophic ulcer and wound, Post-burn complication, Loss of fluid in burns, Sepsis burn, Thermal burns, Thermal skin lesions, Thermal burn, Trophic after-burn ulcers, Chemical burn, Surgical burn

T79.3 Post-traumatic wound infection, not elsewhere classified

Inflammation after surgery and trauma, Inflammation after trauma, Secondary infection of skin and mucous membrane damage, Deep Wounds, Purulent wound, Purulent necrotic phase of wound process, Purulent-septic diseases, Purulent wounds, Purulent wounds with the presence of deep cavities, Granulating wounds of small size, Disinfection of purulent wounds, Wound Infections, Infections wound, Infection of wounds, Infected and non-healing wound, Infected postoperative wound, Infected wound, Infected Skin Wounds, Infected burns, Infected Wounds, Suppurating postoperative wounds, Extensive purulent-necrotic process of soft tissues, Burn infections, Burn infection, Perioperative infection, Poorly healing infected wound, Postoperative and purulent-septic wound, Postoperative wound infection, Wound infection, Wound botulism, Wound infections, Wounds of purulent, Wounds infected, Reinfection of granulating wounds, Sepsis posttraumatic

Z100 * CLASS XXII Surgical practice

Abdominal surgery, adenomectomy, Amputation, Coronary angioplasty, Angioplasty of the carotid arteries, Antiseptic skin treatment for wounds, Antiseptic Hand, Appendectomy, atherectomy, Balloon coronary angioplasty, Vaginal hysterectomy, The coronary bypass, Interventions in the vagina and cervix, Interventions on the bladder, Intervention in the mouth, Restoration and reconstructive surgery, Hand hygiene of medical personnel, Gynecologic surgery, Gynecological intervention, Gynecological surgery, Hypovolemic shock during operations, Disinfection of purulent wounds, Disinfection of wounds edges, Diagnostic intervention, Diagnostic procedures, Cervical Diathermocoagulation, Long-surgery, Replacing the fistula catheters, Infection in orthopedic surgery, Artificial heart valve, cystectomy, Short-term outpatient surgery, Short-term operation, Short surgical procedures, Krikotireotomiya, Blood loss during surgery, Bleeding during surgery and in the postoperative period, Kuldotsentez, laser photocoagulation, laser coagulation, retinal laser coagulation, Laparoscopy, Laparoscopy in Gynecology, CSF fistula, Small gynecological operations, Small surgical procedures, Mastectomy and subsequent plastic, mediastinotomy, Microsurgical operations on the ear, Mukogingivalnye operation, suturing, Minor surgery, neurosurgical operation, Immobilization of the eyeball in ophthalmic surgery, testectomy, pancreatectomy, Perikardektomiya, The period of rehabilitation after surgery, The period of, convalescence after surgery, Percutaneous transluminal coronary angioplasty, Pleural thoracentesis, Pneumonia postoperative and posttraumatic, Preparation for surgical procedures, Preparation for surgery, Preparation of the surgeon's hands before surgery, Preparation of the colon for surgical procedures, Postoperative aspiration pneumonia in neurosurgical and thoracic surgery, Postoperative nausea, Postoperative bleeding, postoperative granuloma, postoperative shock, The early postoperative period, myocardial revascularization, Radiectomy, gastric Resection, bowel resection, uterine Resection, liver Resection, enterectomy, Resection of part of the stomach, Reocclusion of the operated vessel, Bonding tissues during surgical procedures, Removal of sutures, Condition after eye surgery, Condition after surgery, Condition after surgery in the nasal cavity, Condition after gastrectomy, Status after resection of the small intestine, Condition after tonsillectomy, Condition after removal of the duodenum, Condition after phlebectomy, Vascular surgery, Splenectomy, Sterilization of surgical instruments, Sterilization of surgical instruments, sternotomy, Dental surgery, Dental intervention in periodontal tissues, strumectomy, Tonsillectomy, Thoracic surgery, total gastrectomy, Transdermal intravascular coronary angioplasty, Transurethral resection, Turbinektomiya, Removal of a tooth, cataract surgery, Removal of cysts, tonsillectomy, Removal of fibroids, Removing the mobile primary teeth, Removing polyps, Removing broken tooth, Removal of the uterus body, Removal of sutures, Urethrotomy, Fistula likvoroprovodyaschih ways, Frontoetmoidogaymorotomiya, Surgical infection, Surgical treatment of chronic limb ulcersm, Surgery, The surgery in the anal area, The surgery on the colon, Surgical practice, The surgical procedure, Surgical interventions, Surgery on the gastrointestinal tract, Surgical procedures on the urinary tract, Surgical procedures on the urinary system, Surgical intervention of the genitourinary system, Surgical procedures on the heart, Surgical manipulation, surgery, Surgery on the veins, Surgical intervention, Vascular surgery, Surgical treatment of thrombosis, cholecystectomy, Partial gastric resection, transabdominal hysterectomy, Percutaneous transluminal coronary angioplasty, Percutaneous transluminal angioplasty, Coronary artery bypass, tooth Extirpation, Extirpation of milk teeth, pulpectomy, pulsative cardiopulmonary bypass, tooth Extraction, teeth Extraction, cataract extraction, Electrocoagulation, endourological intervention, episiotomy, Etmoidotomiya, Complications after tooth extraction

Code CAS 67-68-5

Characteristics of Dimethylsulfoxide

Colorless transparent liquid or colorless crystals melting at a temperature of 18.5 ° C, with a specific odor. Hygroscopic. Miscible in all proportions with water and alcohol. Molecular weight is 78.13.

Pharmacology

Pharmacological action - anti-inflammatory.

It has local anesthetic, local anti-inflammatory, antimicrobial (antiseptic) and fibrinolytic action. Quickly and well penetrates through biological membranes, incl. through the skin and mucous membranes, increases their permeability for other drugs. Changes the sensitivity of microflora, resistant to antibiotics. In most cases, it is used in combination with other medicinal substances (previously dissolved in it or applied to the skin) for better and deeper penetration into tissues (for example, with heparin in the treatment of thrombophlebitis, with glucocorticoids in the treatment of eczema, with antimicrobials in the treatment of furunculosis , erysipelas, acne, etc.).

Application of Dimethylsulfoxide

Rheumatoid arthritis, Bechterew's disease, deforming osteoarthritis, reactive synovitis, sciatica, scleroderma, erythema nodosum, discoid lupus erythematosus, erysipelatous inflammation; bruises, sprains, inflammatory swelling; infiltrates (including traumatic); purulent wounds, burns, trophic ulcers, thrombophlebitis, eczema, acne, pustular skin diseases (pyoderma, furunculosis - as part of complex therapy); in skin and plastic surgery - preservation of skin homotransplants; in stomatology - inflammatory diseases of the maxillofacial region, salivary glands, periodontitis, pulpitis, periodontitis, arthritis and arthrosis of the temporomandibular joint.

Contraindications

Hypersensitivity, severe hepatic and / or renal failure, myocardial infarction, stenocardia, severe atherosclerosis, glaucoma, cataract, stroke, coma, pregnancy, breast-feeding.

pregnancy and lactation

The action category for fetus by FDA is C.

Side effects

Itching dermatitis, skin rashes, dry skin, mild burning, itching; rarely - bronchospasm.

Interaction

Increases absorption and enhances the effect of other, jointly applied drugs. Compatible with heparin, antibacterial agents, NSAIDs. Increases the sensitivity of microorganisms to aminoglycoside and beta-lactam antibiotics; chloramphenicol, rifampicin, griseofulvin.

Routes of administration

On skin (in the form of applications).

Precautions for Dimethylsulfoxide

When allergic reactions occur, it is necessary to prescribe antihistamines.

special instructions

For the purpose of assessing individual tolerability, it is recommended to perform a drug test, for which a solution of the drug is applied to the skin with a cotton swab. The appearance of sharp reddening and itching indicates a heightened sensitivity.

Some patients do not tolerate the smell of the drug (nausea, vomiting are possible).