Instruction for use: Dihydroergotamine

Trade name of the drug – Ditamin

Chemical rational name: (5'alfa, 10alfa) -9,10-dihydro-12'-hydroxy-2'-methyl-5 '- (phenylmethyl) ergotaman-3', 6 ', 18-trione (as mesylate)

Dosage Form: Colorless transparent solution

Description of Dihydroergotamine

It refers to a group of hydrogenated derivative of ergot alkaloids.

Pharmacotherapeutic group:

Alpha-blockers

Serotonergic solution

The nosological classification (ICD-10)

G43 Migraine: The pain at migraine, hemiplegic migraine, migraine headache, migraine attack, continuous headache, hemicrania

G43.0 Migraine without aura [simple migraine]

G43.1 Migraine with aura [classical migraine]: basilar migraine; Migraine with aura

G90 Disorders of autonomic [autonomous] nervous system: angiodystonia; vasovegetative manifestations; vasomotor dystonia; vegetative dystonia; autonomic dysfunction; vegetative lability; Vegetative-vascular disorders; autonomic dysfunction; vasoneurosis; Vegetative-vascular dystonia; vegetative-vascular disorders; Vegetative-vascular disorders; Dystonia vegetovascular; Dystonia neurocirculatory; neuro disorder; Cardiopsychoneurosis; Neurocirculatory dystonia of hypertensive type; Primary neurovegetative syndrome; The syndrome of vegetative dystonia

I83 Varicose veins of lower extremities: The feeling of heaviness and fatigue in the lower limbs; Varicose disseminated type; varicose veins; Varicose veins of the lower extremities; Varicose disease of lower limbs; Varicose superficial veins; Varicose veins; Varicose vein disease; varicose syndrome; varicose syndrome; Venous claudication; venous varices; venous disease; The disease of the lower extremities; Prevarikozny syndrome; Predvarikozny syndrome; Chronic varicose veins; Sclerotherapy varices

I95.1 Orthostatic hypotension: Idiopathic orthostatic hypotension; Orthostatic hypotension; orthostatic syndrome; Reactions by type asimpatikotonii

R51 Headache: pain in the head; cephalgia; Pain in sinusitis; Pain in the neck; Pain headache; Headache vasomotor origin; Headache vasomotor origin; Headache with vasomotor disturbances; Headache; Neurological Headache; Continuous headache

Application of a substance Dihydroergotamine:

Arteriogipotonichesky version of headache, migraine, vasospastic angina pectoris, orthostatic hypotension.

Pharmacology

Pharmachologic effect - Mode of action - vasodilator, antimigraine.

It stimulates the 5-HT1D serotonin receptors, blocking the alpha 1 and alpha 2-adrenergic receptors vessels. It is a vasoconstrictor intracranial vessels and has a pronounced neyroingibitornymi properties. Reduces photo- and phonophobia. Several increases the tone of veins. When inhaled (nasal spray) rapidly absorbed, which ensures its high efficiency (mild migraine attacks in 20-30 minutes), and excreted from the body (less risk of adverse effects). If ingestion (tablets) reduced bioavailability. After the / m of effect appears after 15-30 minutes and lasts for 3-4 hours.

Contraindications for Dihydroergotamine

Hypersensitivity expressed arteriosclerosis, organic heart disease, myocardial infarction, hypertension, disturbance of peripheral blood circulation, sepsis, shock, renal failure, I trimester of pregnancy, breast-feeding (at the time treatment is mandatory waiver of breastfeeding).

Dihydroergotamine Dosage and Administration

Inside, intramusculary, subdermally

Pregnancy and breast-feeding

Category effects on the fetus by FDA - X.

Side effect of Dihydroergotamine

Nausea, vomiting, diarrhea, difficulty in nasal breathing, cardiac arrhythmias (rare), dizziness, edema, pruritus.

Overdose of Dihydroergotamine

If there is increased sensitivity to ergotaminovym drugs may appear symptoms of ergotism - chest pain, respiratory depression, muscle weakness, pain and paresthesia in the extremities, accompanied by cyanosis and weakening surge in the peripheral vessels, expressed ischemic changes in fingers and toes (rarely), vomiting, diarrhea , delirium, convulsions, coma.

Treatment: emergency removal of the drug, local hot compress, the appointment of vasodilators (sodium nitroprusside, phentolamine), nursing care to prevent tissue damage.

Interaction

Effect increase antihistamines, sedatives and opiates. Concomitant use of with others. Antimigraine drugs (ergotamine, sumatriptan) increases the probability of vasospasm. It enhances the effect of certain antihypertensive agents. Macrolides increase the concentration of dihydroergotamine blood.

Precautions for use Dihydroergotamine

During treatment is not recommended smoking (risk of peripheral vascular spasms increases).