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Instruction for use: Differin

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Active substance Adapalene

ATX code D10AD03 Adapalene

Pharmacological group

dermotropic means

Nosological classification (ICD-10)

L70.0 Acne vulgaris

Ugropodobnye rashes, Congenital youthful acne, Acne vulgaris, Acne vulgaris, Common Acne, Acne draining, Youthful pimples, Youthful Acne, Acne youthful

Composition and form of release

Gel for external use 0,1% 1 g

adapalene 1 mg

auxiliary substances: propylene glycol; methylparahydroxybenzoate; phenoxyethanol; carbomer 940 P; disodium edetate; poloxamer 182; sodium hydroxide; purified water

in tubes of plastic for 30 grams, in a pack of cardboard 1 tuba.

Cream for external use 0,1% 1 g

adapalene 1 mg

auxiliary substances: Carbomer 974P (934 P); macrogol methyldextrose sesquistearate; glycerol; squalane natural; methyldextrose sesquistearate; disodium edetate; methylparahydroxybenzoate; propyl parahydroxybenzoate; phenoxyethanol; cyclomethicone; sodium hydroxide; purified water

in tubes of aluminum for 30 grams, in a pack of cardboard 1 tube.

Description of dosage form

Gel or cream of white color.

pharmachologic effect

Pharmacological action - anti-inflammatory, comedolitic.


Adapalene is a retinoid metabolite, has a comedonolytic and anti-inflammatory activity, normalizes the processes of keratinization and epidermal differentiation. The mechanism of action of adapalene is based on interaction with specific γ-receptors of skin epidermal cells. As a result of the action of adapalene, in particular, there is a decrease in the "cohesion" of epithelial cells at the mouth of the sebaceous-hair follicle and a reduction in the prerequisites for the formation of micro-comedones. Adapalene has an anti-inflammatory effect in vivo and in vitro, affecting inflammatory factors by inhibiting the migration of leukocytes in the focus of inflammation and the metabolism of arachidonic acid.


Absorption of adapalene through the skin is very low (about 4% of the applied dose). Excretion from the body occurs mainly through bile.




Hypersensitivity to one of the ingredients of the drug.

CAREFULLY. Dermatitis, eczema.

pregnancy and lactation

It is not recommended to use the drug during pregnancy and breastfeeding.

Side effects

Skin irritation (treatment should be stopped until skin irritation disappears or frequency of application is reduced).


Because the drug does not interact with oxygen and does not break down under the influence of light, it can be used with other local and systemic drugs for the treatment of acne, such as clindamycin phosphate or benzoyl peroxide (see "Special instructions").

Dosing and Administration

Outwardly. With a gentle touch, apply the gel or cream evenly to the affected surface once a day before going to bed to clean, dry skin, avoiding contact with the eyes and lips.

The therapeutic effect develops after 4-8 weeks of treatment, a persistent improvement after 3 months of treatment.

In some cases, due to short-term skin irritation, the number of applications may be reduced or the treatment suspended until the signs of irritation disappear.

Repeated treatment is possible after consultation with a doctor.


Overdose is unlikely.

special instructions

Avoid getting a gel or cream into the eyes, lips and mucous membranes.

If you accidentally get the drug on the mucous membranes of the eyes, mouth or nose, rinse them thoroughly with warm water.

Avoid direct sunlight. may cause mild skin irritation. Treatment can be continued if the solar exposure is minimized (using sunglasses and hats).

It is not recommended simultaneous use of cosmetics with drying or irritating effects on the skin (eg perfume or alcohol-containing products).

Adapalene, applied to the skin in the evening, can be combined with anti-acne medications used in the morning.

storage conditions

At a temperature of no higher than 25 C. Do not freeze.

Keep out of the reach of children.

Shelf Life

3 years.

Do not use after the expiry date printed on the package.

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