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Instruction for use: Diazepam Nycomed

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Trade name of the drug – Diazepam Nycomed

Active substance: Diazepamum (genus. Diazepami)

Chemical name: 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

Dosage Form: tablets, solution for injection

Composition of Diazepam Nycomed

1 tablet contains diazepam 2 or 5 mg, in bottles of 30 pcs., In a carton one bottle.
One ampoule 2 ml solution for injection - 10 mg; in a blister pack 5 pcs., in a carton 2 blisters.

Pharmacotherapeutic group: Anxiolytics, antiepileptics

ATX Code

N05BA01 Diazepam

The nosological classification (ICD-10)

F10.3 abstinence: Alcohol withdrawal syndrome; abstinence symptom; Abstinence syndrome in alcoholism; abstinence; alcohol abstinence; alcohol withdrawal; Alcohol abstinence; Alcohol withdrawal syndrome; withdrawal disorder; withdrawal state; alcohol withdrawal syndrome; withdrawal syndrome; The syndrome of alcohol abstinence; alcohol withdrawal syndrome; Status of abstinence.

F10.4 abstinent state with delirium: Delirium tremens; Delirium tremens alcohol; delirium; Delirious state in alcoholism and drug addiction.

F10.5Alcoholic psychosis: Alcoholic hallucinosis; Alcoholic psychosis; Delirium tremens alcohol; delirium; Delirium in alcoholism; Delirious state in alcoholism and drug addiction; Acute alcoholic psychosis; Acute alcoholic psychosis with autonomic disorders; Psychoorganic syndrome in chronic alcoholism.

F20 Schizophrenia: Dementia praecox; Bleuler's disease; Sluggish schizophrenia; Sluggish schizophrenia apatoabulicheskimi with disabilities; Exacerbation of schizophrenia; The acute stage of schizophrenia with excitement; The acute form of schizophrenia; Acute schizophrenia; Acute schizophrenic disorders; An acute attack of schizophrenia; Psychosis discordant; Schizophreniform psychosis; Dementia early; Febrile form of schizophrenia; Chronic schizophrenia; Chronic schizophrenic disorders; Cerebral organic deficiency in schizophrenia; Schizophrenic state; Schizophrenic psychosis; Schizophrenia.

F41 Other anxiety disorders: anxiety Relief; Nonpsychotic anxiety disorders; An alarm condition; Anxiety; Disturbingly suspicious condition; Chronic anxiety; Sense of anxiety.

G24 Dystonia: Violation of muscle tone.

G47.0 Disorders of falling asleep and maintaining sleep [insomnia]: Insomnia; Insomnia, especially difficulty falling asleep; desynchronosis; Prolonged sleep disturbance; Difficulty falling asleep; Short-term and transient insomnia; Short-term and chronic sleep disorders; Short or shallow sleep; Violation of sleep; Disturbed sleep, especially in the phase of falling asleep; Infringements sleep; sleep disturbances; Neurotic sleep disturbance; Shallow superficial sleep; shallow sleep; Poor quality of sleep; Night awakening; sleep Pathology; Postsomnic violation; transient insomnia; Trouble falling asleep; Early awakening; Early morning awakening; Early awakening; sleep disorder; somnipathy; persistent insomnia; difficult to fall asleep; difficulty falling asleep; Difficulty falling asleep in children; persistent insomnia; Worsening sleep; Chronic insomnia; Frequent night and / or early morning awakening; Frequent nocturnal awakening and a sense of the depth of the non-sleep; Night waking.

R25.2 Cramp and spasm: Painful muscle spasm; Mimic spasm; Muscle spasticity; Muscle spasms; Muscle spasms in tetanus; Muscle spasms of central origin; Muscle spasms of; Muscle spasm; Neurological contracture with spasms; Night cramps in the limbs; Night cramps in the legs; Night leg cramps; Symptomatic convulsive state; West syndrome; Smooth muscle spasm; Spasm of smooth muscle; Spasm of vascular smooth muscle; Muscle spasms; The spasm of the striated muscles due to organic diseases of the central nervous system; The spasm of skeletal muscles; The spasms of smooth muscles of internal organs; Muscle cramps; The spasms of skeletal muscles; Spastic condition of striated muscle; Spastic pain; Spasmodic state of smooth muscle; Spasticity of the skeletal muscles; Muscle cramps; Convulsions; Leg cramps; Seizures of central origin; Convulsive state; Spastic syndrome; Convulsive status in children; Tonic seizures; The phenomenon of folding knife; Cerebral spastic syndrome.

R45.1 Restlessness and agitation: Agitation; Anxiety; explosive excitability; The internal excitation; Excitability; Excitation; Excitation sharp; psychomotor excitement; hyperexcitability; motor stimulation; Relief of agitation; jitters; restless; Night concern; The acute stage of schizophrenia with excitement; Acute mental stimulation; paroxysm excitation; overexcitement; erethism; Increased nervous irritability; Increased emotional and cardiac excitability; Increased arousal; hyperphrenia; Psychomotor agitation; Psychomotor agitation; Psychomotor agitation in psychosis; Psychomotor agitation epileptic nature; psychomotor paroxysm; psychomotor seizures; excitation Symptoms; The symptoms of psychomotor agitation; Status agitation; Status anxiety; excitation condition; Status of high concern; Condition of psychomotor agitation; anxiety states; excited states; anxiety states with somatic diseases; feeling of excitation; Feeling restless; Emotional arousal.

Z100 * CLASS XXII Surgical practice

Pharmacological Properties of Diazepam NycomedPharmachologic effect

Mode of action - an anticonvulsant, muscle relaxant, anxiolytic.

Pharmacokinetics

Completely absorbed from the gastrointestinal tract. The action develops within 15-30 minutes. Cmax in plasma attained in 30-60 minutes after administration. T1 / 2 - 20-45 hours, the newborn can reach 100 hours Plasma protein binding -. 96-98%. It is metabolized in the liver with the formation of active metabolites that are excreted by the kidneys.

Indications for Diazepam Nycomed

Anxiety (chronic, neurotic, and acute situational stress). Stress, sleep disorders, psychosomatic condition, schizophrenia, borderline disorders, convulsions, facial spasms, abstinence, predeliry, delirium, premedication.

Contraindications for Diazepam Nycomed

Acute alcohol and sedatives, myasthenia gravis, sleep apnea, acute respiratory failure, severe liver failure, pregnancy (I and III trimester), breastfeeding (4 weeks after giving birth), age (up to 2 years). Contraindicated in pregnancy (I and III trimester). At the time of treatment should stop breastfeeding.

Diazepam Nycomed Dosage and Administration

V / m or /.

Status epilepticus: in / in slowly 0.15-0.25 mg / kg, when it is impossible to / in the same dose / m. If necessary - re-introduction in 30-60 min; acceptable drip infusion (maximum dose of 3 mg / kg / day).

Tetany: a / c, very slowly, 0.1-0.3 mg / kg at intervals of 1-4 hours, or drip 3-4 mg / kg / day.

Muscle spasms of central origin: V / m or slow-in / first 10-20 mg (children 2-10 mg) with continued ingestion of the drug. Muscle spasms peripheral origin: / m 10-20 mg 1-2 times a day.

Preeclampsia: w / w 10 mg slow at first, if necessary, further be administered in / or in the form of drip infusion (up to 100 mg / day).

Side effect of Diazepam Nycomed

Drowsiness, depression, weakness, dizziness, ataxia, itching, muscle weakness, diarrhea disorders, bradycardia, hypotension, menstrual irregularities, gynecomastia, leukopenia, agranulocytosis, aplastic anemia, allergic reactions, bronchospasm, tolerance, drug dependency.

Overdose of Diazepam Nycomed

Symptoms: drowsiness, dizziness, muscle weakness, ataxia, stupor, coma with respiratory depression and collapse.

Treatment: the specific antidote - flumazenil.

Interaction

Neuroleptics, antihistamines, alcohol, clonidine, opioids, hypnotics sedative effect and the effect (inhibitory) on vascular tone. Cimetidine, omeprazole, anti-TB drugs, and oral contraceptives reduce estrogen diazepam metabolism in the body and can cause cumulation. Theophylline weakens the sedation and psychomotor effects.

SPECIAL INSTRUCTIONS for Diazepam Nycomed

If the kidney function and the elderly need to dose reduction. In patients with hepatic impairment and depression used with caution.

Storage conditions of Diazepam Nycomed

2 years.
Do not use beyond the expiration date printed on the package.

In the dark place at a temperature no higher than 25 ° C.
Keep out of the reach of children.

Conditions of supply of Diazepam Nycomed from pharmacies
On prescription.

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