Instruction for use: Dermovate

Active substance Clobetasol

ATX Code D07AB01 Clobetasol

Pharmacological group

Glucocorticosteroids

Nosological classification (ICD-10)

L30.9 Dermatitis, unspecified

Allergic dermatoses complicated by a secondary bacterial infection, Anal eczema, Bacterial maturation, Varicose Eczema, Venous dermatitis, Inflammation of the skin, Inflammation of the skin upon contact with plants, Inflammatory Skin Diseases, Inflammatory skin reactions, Inflammatory processes of the skin, Hypostatic dermatitis, Fungal Eczema, Fungal dermatosis, Dermatitis, Dermatitis is stagnant, Dermatitis and eczema in the anal area, Dermatitis acute contact, Perianal dermatitis, Dermatosis, Dermatosis of the scalp, Dermatosis of psoriasis, Dermatosis with persistent itching, Dermatoses, Dermatoses itchy, Other itching dermatoses, Significant eczematous manifestations, Itching with, dermatoses, Itching eczema, True eczema, Skin reaction to insect bites,Skin itching with dermatosis, Constitutional eczema, Weeping eczema, Drowsing inflammatory skin disease, Dying Infectious-Inflammatory Skin Disease, Non-allergic dermatitis, Nummular eczema, Acute contact eczema, Acute inflammatory skin disease, Acute dermatosis, Acute severe dermatosis, Perianal dermatitis, Superficial dermatosis, Subacute Contact Eczema, Simple dermatitis, Occupational dermatitis, Psychogenic dermatosis, Bubble dermatitis of newborns, Pustular eruptions, Irritation and redness of the skin, Low-flammable eczema, Dry atrophic eczema, Dry eczema, Toxic dermatitis, Ear eczema like dermatitis, Chronic eczema, Chronic dermatosis, Chronic common dermatosis, Scaly papular dermatosis, Eczema, Eczema anal region, Eczema of the hands, Eczema Contact, Eczema lichenized, Eczema Nummular, Eczema acute, Eczema acute contact, Eczema subacute, Eczematous dermatitis, Eczema-like rashes, Ecome exogenous, Endogenous eczema, Gluteal dermatitis, Restricted itchy dermatitis

L40 Psoriasis

Chronic psoriasis with diffuse plaques, Generalized psoriasis, Psoriasis of the scalp, Psoriasis of the scalp, Generalized form of psoriasis, Psoriasis dermatitis, Psoriasis complicated by erythroderma, Invalidative psoriasis, Isolated psoriatic plaque, Exfoliative psoriasis, Psoriatic Erythroderma, Psoriasis with eczematosis, Hyperkeratosis in psoriasis,Inverse psoriasis,Psoriasis eczematous, Dermatosis of psoriasis, Psoriasis of the genitals, Psoriasis with lesions of hairy areas of skin, Erythrodermal psoriasis, Chronic psoriasis of the scalp, Chronic psoriasis, Ordinary psoriasis, Refractory psoriasis, Kebner phenomenon, Scaly lichen

L43 Red Leaf Flat

Lishay Wilson, Erosive-ulcerative form of red flat lichen, Warty forms of red lichen, Red lichen, Flat lichen, Kebner phenomenon

L93.0 Discoid lupus erythematosus

Chronic discoid lupus erythematosus, Red discoid lupus, Discoid lupus, Discoid erythematosis

Composition and form of release

Cream 100 g

Clobetasol propionate 0.05 g

Auxiliary substances: glycerol monostearate; Arlacel 165; A substitute for beeswax 6621; Ketosterol alcohol; Propylene glycol; Chlorocresol; Sodium citrate; Acid lemon monohydrate; purified water

In tubes of 25 g; In the box 1 tuba.

Ointment 100 g

Clobetasol propionate 0.05 g

Auxiliary substances: propylene glycol; Sorbitan sesquioleate; White soft paraffin up to 100 g

In tubes of 25 g; In the box 1 tuba.

pharmachologic effect

Pharmacological action - anti-inflammatory.

Has glucocorticoid activity.

Pharmacodynamics

Eliminates edema, flushing, itching at the site of application.

Indications

Psoriasis (except for common plaque), chronic eczema, flat lichen, discoid lupus erythematosus, skin diseases that are not amenable to the effects of other steroids.

Contraindications

Hypersensitivity; Acne pink and youthful; Perioral dermatitis, skin infections viral (simple herpes), fungal (candidiasis), bacterial (impetigo); Perianal and genital itching; Dermatosis in children under 1 year (including dermatitis and rash with diaper rash).

pregnancy and lactation

With caution, tk. There is no sufficient data on the safety of use during pregnancy and lactation.

Side effects

With prolonged use - atrophic changes on the face and other areas of the body (warts, thinning of the skin, vasodilation), weakening of the barrier functions of the skin, rarely - the emergence of a pustular form of psoriasis.

Dosing and Administration

Outwardly. Cream and ointment applied a thin layer on the affected skin 1-2 times a day before the onset of improvement. Treatment can not be conducted more than 4 weeks without an assessment of the need for its continuation. With exacerbations of skin diseases, repeated short courses of treatment with Dermovate® are possible. If continued therapy with glucocorticoids is necessary, less active drugs should be used. In particularly resistant cases, especially with hyperkeratosis, the anti-inflammatory effect of the cream and Dermovate® ointment can be enhanced by applying an occlusive dressing overnight to the affected area with a PE film. After this, the achieved improvement is supported by the use of the drug without an occlusive dressing.

Overdose

It manifests as signs of hypercorticism (requiring the drug to be withdrawn).

Precautionary measures

In the absence of improvement within 2-4 weeks, one should question the correctness of the diagnosis. In case of exacerbations, short repeated courses are necessary. In patients with psoriasis, the barrier function of the skin may be weakened, pustular psoriasis may develop, tolerance develop, relapses may develop. It is necessary to avoid prolonged and uninterrupted use in children, especially in nursing infants. It is possible to suppress the function of the adrenal cortex. In infants, diapers can act as occlusive dressings and increase the absorption of corticosteroids. On the face the drug is used for 5 days and without an occlusive bandage. Before applying a fresh bandage, the skin should be cleaned. Heat and humidity created by hermetically sealed (occlusive) dressings, contribute to the emergence of bacterial infection. Accession of bacterial infection requires discontinuation of the use of the drug and the appointment of antibiotic therapy. The drug should not fall into the eye (glaucoma may develop). Long-term use of large amounts (or large areas) can lead to systemic absorption (hypercorticism).

storage conditions

At a temperature not exceeding 30 ° C.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.