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Instruction for use: Dermaref

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Dosage form

Ointment for external use


Ingredients per 100 g:

Active substance: bien - 5.0 g,

Auxiliary substances: geranium oil (fraction 1) 0.1 g, sunflower oil 10.0 g, emulsion wax 10.0 g, glycerol 5.0 g, glyceryl monostearate 1.0 g, methyl parahydroxybenzoate 0, 15 g, propyl parahydroxybenzoate - 0.05 g, purified water - up to 100 g.

Description of dosage form

Ointment is light yellow with a weak specific odor.

Pharmacological group

Dermatoprotective agent of plant origin.

Pharmacological (immunobiological) properties

Bien - a mixture of ethyl esters of polyunsaturated fatty acids, obtained from the lipids of the filamentous fungus Entomophthora virulenta, the family Entomophthoraceae, the class Zygomycetes, the E. coli strain stabilized by alpha-tocopherol acetate (vitamin E). Bien for 90-95% consists of higher fatty acids. Biene contains: ethyl esters of α-linolenic acid (ω-3); linoleic acid (ω-6); γ-linolenic acid (ω-6); arachidonic acid (ω-6); eikosadienoic acid (ω-6); eicosatrienoic acid (ω-6); palmitic acid (ω-7); palmitoleic acid (ω-9); oleic acid (ω-9), as well as ethyl esters of stearic acid and myristic acid. Unsaturated fatty acids, including essential (linoleic, α-linolenic and arachidonic) are important components of biomembranes and sources of eicosanoids - universal bioregulators for the functional activity of cells and tissues. Biene is characterized by a balanced ratio of polyunsaturated fatty acids of families ω-6 and ω-3 series, has a cytoprotective effect, enhances reparative processes.

Essential polyunsaturated fatty acids (PUFA) and their derivatives - eicosanoids - have a modulating effect on the development of hyperreactivity and the formation of allergic inflammation, proliferative processes. Arachidonic acid metabolite prostaglandin PGE2 at low concentrations inhibits the migration of leukocytes and the release of inflammatory mediators from mast cells. Eicosanoids, which exert a dose-dependent anti-inflammatory effect, also include PGE1, PG F2α, PGD2.

Ointment has an anti-inflammatory effect and stimulates the reparative processes in the skin (reduces flushing and swelling, reduces the burning sensation of the skin, contributes to the epithelization of the wound defect).


Virtually not absorbed through the skin, does not enter the systemic bloodstream. Through damaged skin is absorbed in small amounts.


As part of complex therapy, for symptomatic treatment of skin manifestations of dermatitis (atopic, allergic, contact), eczema (true, seborrheic).


hypersensitivity to the components of the drug;

bacterial, viral and fungal skin diseases (including herpes simplex, chicken pox, skin tuberculosis, actinomycosis);

eczema in the stage of exacerbation with the phenomena of wetness;

syphilitic skin lesions;


the period of breastfeeding;

children's age till 18 years.

pregnancy and lactation

The safety of the use of the drug during pregnancy and during breastfeeding has not been studied. The use of the drug is contraindicated in pregnancy and during breastfeeding.

Dosing and Administration

Outwardly. Ointment is applied to the damaged or inflamed skin area with a thin layer 1-2 times a day. The course of treatment is 10-15 days. The course of treatment can be prolonged on the recommendation of a doctor.

Side effects

Allergic reactions (hives, itching), burning in the place of application. If side effects occur, stop using the ointment.


Cases of overdose with the use of the drug is not described.


Cases of interaction with other drugs are unknown.

special instructions

Influence on ability to drive vehicles and other dangerous mechanisms:

The drug does not affect the ability to drive vehicles and other potentially dangerous mechanisms.

Form of issue

Ointment for external use.

By 15, 25, 30 g in tubes are aluminum. Each tube together with the instruction for use is placed in a pack of cardboard.

Storage conditions

In a dry, dark place at a temperature of no higher than 8 C.

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiration date printed on the package.

Conditions of leave from pharmacies

On prescription.

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