Instruction for use: Derinat

Dosage form: Solution for intramuscular injection; Solution for local and external use

Active substance: Natrii deoxyribonucleas

ATX

B03XA Other anemia drugs

Pharmacological group:

Immunomodulating agent, hematopoiesis stimulant, regenerant, reparant [Other immunomodulators]

The nosological classification (ICD-10)

A16 Tuberculosis of respiratory organs, not confirmed bacteriologically or histologically

A41.8 Other specified septicemia: Fungal sepsis; Abdominal sepsis; Sepsis; Sepsis burn; Surgical sepsis; Sepsis tonsilogenous

A49 Bacterial infection of unspecified site: Bacterial infection; Infectious diseases

A49.3 Mycoplasma infection, unspecified: Mycoplasma infection; Urogenital mycoplasmosis; Pulmonary infection caused by mycoplasma; Mycoplasma infections; Mycoplasmosis; Genitourinary infection caused by mycoplasma; Mycoplasma meningoencephalitis

A49.8 Other bacterial infections of unspecified site: Odontogenic infection

A56 Other chlamydial diseases, sexually transmitted infections: Chlamydial infections; Chlamydia; Tropical bubo

A63.8 Other specified diseases, mainly sexually transmitted: Ureaplasmosis infection; Ureaplasmic infection; Ureaplasmosis

A64 Sexually transmitted diseases, unspecified: Infections of the male genital tract; Venereal infections; Sexually Transmitted Infections

B99 Other infectious diseases: Infections (opportunistic); Infections on the background of immunodeficiency; Opportunistic infections

B99.9 Other and unspecified infectious diseases

D26 Other benign neoplasms of the uterus: Fibromyoma of the uterus; Myoma; Uterine fibroids; Fibromyoma; Myoma of the uterus; Fibrrios; Meigs syndrome; Tumors of the uterus

D64.9 Anemia, unspecified: Anemic states; Anemia of various origins; Hematopoietic disorders

D84.8 Other specified immunodeficiency disorders: Immunodeficiency due to loss of protein; Immunodeficiency states secondary; Immunodeficiency states with protein loss; Secondary Immune Deficiency; Secondary immunodeficiency status; Secondary immunodeficiency states; Secondary immunodeficiency; Acquired immunodeficiency; Syndrome of secondary immunodeficiency; Secondary immunodeficiencies; Immunodeficiency states primary

I25.9 Chronic ischemic heart disease, unspecified: CHD; Insufficiency of coronary circulation; Coronary atherosclerosis in patients with coronary artery disease

I70.2 Atherosclerosis of arteries: arteriosclerosis obliterans; Arteriosclerosis peripheral arteries; Atherosclerosis of the arteries of the lower extremities; Atherosclerosis of peripheral arteries; Atherosclerosis limbs; Occlusive disease of the lower extremities; arteriosclerosis obliterans; Arteriosclerosis obliterans of lower limb arteries; Atherosclerosis obliterans of the upper limbs; Arteriosclerosis obliterans of lower extremities; Atherosclerosis of arteries; limb arteriopathy; Arteriosclerosis obliterans limbs; arteriosclerosis obliterans

I73 Other peripheral vascular disease: peripheral angiopathy; limb arteriopathy; The disease of arteries; Violations of peripheral arterial circulation; Lack of blood flow arteriovenous; Obliterating diseases of arteries; occlusive disease; Occlusive disease with severe intermittent claudication; obliterating diseases of arteries; Chronic obliterating peripheral arterial disease; endarteritis obliterans; Ischemic lesions stop

I73.9 Peripheral vascular disease, unspecified: angiospasm; Vasospasm / vasoconstriction; vasospastic disorders; Violation of venous microcirculation; Violation of circulation; Violation of peripheral blood circulation; Lack of peripheral blood circulation in the lower and upper limbs; Peripheral arterial occlusive disease; Peripheral arterial occlusive disease in stages III-IV on Fontaine; Peripheral vascular insufficiency; Peripheral vascular lesions; Peripheral vascular disorders; Peripheral circulatory disorder; spasm of artery; angiospasm; Functional peripheral arterial disease; Chronic occlusive disease; Chronic obliterating diseases of the lower limbs; Chronic arterial occlusive disease

I87.2 Venous insufficiency (chronic) (peripheral): Painful foot fatigue; The pain and feeling of heaviness in the legs; The pain of chronic venous insufficiency; Venous insufficiency; Venous insufficiency of the lower limbs; Venous-lymphatic insufficiency; Venous edema; phlebostasis; Ischemic lesions stop; Lipedema; Microcirculatory-trophic disorders; Violation of venous circulation; Violation of venous circulation of the lower limbs; Disorders of venous circulation; Disorders of the peripheral circulation in the extremities; Lack of chronic venous; Insufficiency of venous circulation; Organic venous insufficiency of the lower limbs; Acute venous insufficiency of the lower limbs; Swelling in the legs; limb edema; Swelling in the legs; Swelling of lower limbs due to chronic venous insufficiency; Swelling of the legs; Edematous pain in venous insufficiency; Swelling and pain in the legs; The feeling of heaviness in the legs; Prevarikozny syndrome; The static heaviness in the legs; Trophic tissue changes; Trophic tissue disorders; Trophic disorders; Heaviness in the legs; Fatigue in the legs; Chronic venous insufficiency; Chronic venous insufficiency of the lower limbs; Chronic ischemic disease of the lower extremities; Chronic insufficiency of venous circulation; The feeling of heaviness in the legs; The feeling of heaviness in the legs during pregnancy; The feeling of heaviness in the legs after prolonged standing

J06 Acute upper respiratory tract infections of multiple and unspecified locations: Frequent colds of viral diseases; Infections of ENT organs; Acute respiratory illness of influenza nature; Pain for colds; Acute catarrhal disease; Cold; Colds; Colds; Respiratory infection; Seasonal catarrhal disease; Seasonal colds; Pain in infectious and inflammatory diseases of the upper respiratory tract; Bacterial infections of the upper respiratory tract; Bacterial infections of the respiratory system; Viral respiratory disease; Viral respiratory tract infections; Inflammatory disease of the upper respiratory tract; Inflammatory diseases of the upper respiratory tract; Inflammatory diseases of the upper respiratory tract with difficult to separate sputum; Inflammatory respiratory disease; Secondary infections for colds; Difficult sputum separation in acute and chronic respiratory diseases; Upper respiratory tract infections; Infections of the upper respiratory tract; Respiratory tract infections; Respiratory and lung infections; Infectious-inflammatory diseases of the upper respiratory tract; Infectious-inflammatory diseases of the upper respiratory tract and ENT organs; Infectious-inflammatory diseases of the upper respiratory tract in adults and children; Infectious-inflammatory diseases of the upper respiratory tract; Infectious inflammation of the respiratory tract; Respiratory tract infection; Qatar upper respiratory tract; Catarrh of the upper respiratory tract; Catarrh of the upper respiratory tract; Catarrhal phenomena from the upper respiratory tract; Cough in diseases of the upper respiratory tract; Cough for colds; ARVI; ARI; ARI with phenomena of rhinitis; Acute respiratory infection; Acute infectious-inflammatory disease of the upper respiratory tract; Acute respiratory disease; Persecution in the throat or nose; Respiratory and viral infections; Respiratory diseases; Respiratory infections; Recurrent respiratory tract infections; Secondary infections with influenza; Influenza states; Feverish conditions for influenza

J22 Acute respiratory infection of lower respiratory tract, unspecified: Bacterial respiratory disease; Bacterial infections of the lower respiratory tract; Bacterial infections of the respiratory system; Viral respiratory disease; Viral respiratory tract infections; Inflammatory respiratory disease;; Difficult sputum separation in acute and chronic respiratory diseases; Respiratory tract infections; Respiratory and lung infections; Lower respiratory tract infections; Infections of the lower respiratory tract; Infectious inflammation of the respiratory tract; Infectious diseases of the respiratory tract; Infectious diseases of the lungs; Infectious diseases of the respiratory system; Respiratory tract infection; Cough for colds; Pulmonary infection; Acute respiratory tract infection; Acute respiratory viral infection; Acute inflammatory airway disease; Acute respiratory disease; Respiratory infection; Respiratory and viral infections; Respiratory syncytial viral infection in young children; Respiratory diseases; Respiratory infections

J30 Vasomotor and allergic rhinitis: Allergic rhinopathy; Allergic rhinosinusopathy; Allergic diseases of the upper respiratory tract; Allergic rhinitis; Allergic rhinitis seasonal; Vasomotor runny nose; Prolonged allergic rhinitis; All-year-round allergic rhinitis; All-year allergic rhinitis; Year-round or seasonal allergic rhinitis; All-the-year-round rhinitis of an allergic nature; Rhinitis vasomotor allergic; Exacerbation of pollinosis in the form of rhinoconjunctival syndrome; Acute allergic rhinitis; Edema of the nasal mucosa; Edema of the nasal mucosa; Edema of the mucous membrane of the nasal cavity; Swelling of the nasal mucosa; Swelling of the nasal mucosa; Pollinosis; Permanent allergic rhinitis; Rhinoconjunctivitis; Rhinosinusitis; Rhinosinusopathy; Seasonal allergic rhinitis; Seasonal allergic rhinitis; Hay rhinitis; Chronic allergic rhinitis; Allergic diseases of the respiratory tract

J30.1 Allergic rhinitis caused by pollen of plants: Hay fever; Hay fungus; hay fever; Hypersensitivity to pollen of plants; Polyposis allergic rhinosinusitis; Seasonal pollinosis; Seasonal rhinitis

J44 Other chronic obstructive pulmonary disease: Allergic bronchitis; Bronchitis allergic; Asthmatic bronchitis; Bronchitis obstructive; Disease of the bronchi; Difficult sputum separation in acute and chronic respiratory diseases; Cough with inflammatory diseases of the lungs and bronchi; Reversible bronchial obstruction; Reversible obstructive airway disease; Obstructive bronchial disease; Obstructive pulmonary disease; Obstructive bronchitis; Spastic bronchitis; Chronic lung diseases; Chronic nonspecific lung diseases; Chronic Obstructive Pulmonary Diseases; Chronic obstructive bronchitis; Chronic obstructive airways disease; Chronic obstructive pulmonary disease; Restrictive pathology of the lungs

J44.9 Chronic obstructive pulmonary disease, unspecified: Obstructive pulmonary pathology; Bronchial obstruction; Bronchoobstructive syndrome; Exacerbation of chronic obstructive pulmonary disease; Reversible bronchial obstruction; Reversible airway obstruction; Panbronchiolitis; Panbronchitis; COPD; Chronic lung infection; Chronic infection of the lower respiratory tract; Chronic obstructive pulmonary disease; Chronic Obstructive Pneumonia; Chronic lung diseases; Chronic Obstructive Pulmonary Diseases; Chronic bronchopulmonary disease; Chronic broncho-pulmonary diseases; Obstruction of the respiratory tract

J45 Asthma: Asthma of physical effort; Asthmatic conditions; Bronchial asthma; Bronchial asthma of light course; Bronchial asthma with difficulty in sputum discharge; Bronchial asthma of severe course; Bronchial asthma physical effort; Hypersecretory asthma; The hormone-dependent form of bronchial asthma; Curbing asthma attacks with bronchial asthma; Non-allergic bronchial asthma; Night Asthma; Exacerbation of bronchial asthma; Attack of bronchial asthma; Endogenous forms of asthma; Night attacks of asthma; Cough with bronchial asthma

K12 Stomatitis and Related Losses: Bacterial stomatitis; Inflammatory diseases of the oral cavity; Inflammatory diseases of tissues of the oral cavity; Inflammatory processes in the oral cavity; Fungal diseases of the mouth; Fungal infections of the oral cavity; Fungal infections and inflammatory diseases of the mouth; Diseases of the mouth; Infectious-inflammatory disease of the oral cavity; Exacerbation of inflammatory diseases of the pharynx and oral cavity; Stomatitis; Angular stomatitis; Chronic recurrent stomatitis; Ulcerative necrotic diseases of the oral mucosa; Ulcerative necrotic diseases of the oral mucosa; Ulcerative necrotic lesions of the oral mucosa; Ulcerative necrotic gingivostomatitis; Ulcerative stomatitis; Erosive-ulcerative lesion of the oral mucosa; Erosive-ulcerative lesions of the mucous membrane of the oral cavity; Erotic mucous membrane of the oral cavity; Recurrent ulcerative stomatitis

K25 Stomach ulcer: Helicobacter pylori; Pain syndrome with gastric ulcer; Pain syndrome with peptic ulcer of stomach and duodenum; Inflammation of the gastric mucosa; Inflammation of the mucosa of the gastrointestinal tract; Benign ulcer of the stomach; Disease of the stomach and duodenum, associated with Helicobacter pylori; Exacerbation of gastroduodenitis against ulcer disease; Exacerbation of peptic ulcer; Exacerbation of gastric ulcer; Organic GI disease; Peptic ulcer of the stomach and duodenum; Postoperative Stomach Ulcer; Recovering ulcers; Symptomatic Stomach Ulcers; Chronic inflammatory disease of the upper gastrointestinal tract associated with Helicobacter pylori; Helicobacter pylori eradication; Erosive-ulcerative lesions of the stomach; Erosive lesions of the stomach; Erosion of the gastric mucosa; Peptic Ulcer; Stomach ulcer; Stomach ulcer; Ulcerative lesions of the stomach; Symptomatic ulcers of the stomach and duodenum

K26 Ulcer of duodenum: Pain syndrome with duodenal ulcer; Pain syndrome with peptic ulcer of stomach and duodenum; Disease of the stomach and duodenum, associated with Helicobacter pylori; Exacerbation of peptic ulcer; Exacerbation of duodenal ulcer; Peptic ulcer of the stomach and duodenum; Recurrence of duodenal ulcer; Symptomatic ulcers of the stomach and duodenum; Helicobacter pylori eradication; Erosive-ulcerative lesions of the duodenum; Erosion-ulcerative duodenal lesions associated with Helicobacter pylori; Erosive lesions of the duodenum; Peptic ulcer disease of the duodenum; Ulcerative duodenal lesions

K29.9 Gastroduodenitis, unspecified: Biliary reflux gastritis; Gastroduodenitis; Gastroduodenitis against a background of normal secretion; Gastroduodenitis on a background of increased secretion; Acute gastroduodenitis; Chronic gastroduodenitis; Chronic gastroduodenitis with normal secretory function; Chronic gastroduodenitis with increased secretory function; Erosive gastroduodenitis

L20 Atopic dermatitis: Allergic diseases of the skin; Allergic skin disease noninfectious etiology; Allergic skin disease etiology nemikrobnoy; Allergic skin diseases; Allergic skin lesions; Allergic reactions on the skin; atopic dermatitis; Allergic dermatosis; Allergic diathesis; Allergic itching dermatosis; Allergic skin disease; Allergic skin irritation; allergic Dermatitis; atopic Dermatitis; allergic dermatoses; exudative diathesis; Itchy atopic eczema Itchy allergic dermatosis; Allergic skin disease; Cutaneous allergic reaction to drugs and chemicals; Cutaneous reactions to medications; Skin and allergic disease; Acute eczema; common neurodermatitis; Chronic atopic dermatitis; Exudative diathesis

L98.4.2 * Trophic skin ulcer: Varicose ulcer; Varicose ulcers; Cutaneous ulcer; Non-healing ulcers; Trophic ulcer; Trophic ulcer of lower leg; Trophic skin lesions; Trophic after-burn ulcers; Trophic ulcers; Trophic skin ulcers; Ulcer of lower leg; Ulcer of skin; Ulcer of trophic skin; Ulcer on legs; Ulcerative necrosis of the skin; Ulcer of shin; Ulcer of the lower leg; Ulcers of lower extremities; Difficult healing ulcers

M06.9 Rheumatoid arthritis, unspecified: Rheumatoid arthritis; Pain syndrome in rheumatic diseases; Pain in rheumatoid arthritis; Inflammation in rheumatoid arthritis; Degenerative forms of rheumatoid arthritis; Children's rheumatoid arthritis; Exacerbation of rheumatoid arthritis; Acute articular rheumatism; Rheumatic arthritis; Rheumatic polyarthritis; Rheumatoid arthritis; Rheumatic polyarthritis; Rheumatoid arthritis; Rheumatoid arthritis; Rheumatoid arthritis of active course; Rheumatoid periarthritis; Rheumatoid polyarthritis; Acute rheumatoid arthritis; Acute rheumatism

N39.0 Urinary tract infection without established localization: Fungal infections of the urinary tract; Asymptomatic bacteriuria; Bacterial infections of the urinary tract; Bacterial infections of the urinary tract; Bacterial infections of the genitourinary system; Bacteriuria; Bacteriuria asymptomatic; Bacteriuria chronic latent; Asymptomatic bacteriuria; Asymptomatic massive bacteriuria; Inflammatory urinary tract disease; Inflammatory urinary tract disease; Inflammatory diseases of the bladder and urinary tract; Inflammatory diseases of the urinary system; Inflammatory diseases of the urinary tract; Inflammatory diseases of the urogenital system; Fungal diseases of the urogenital tract; Urinary Tract Infections; Urinary Tract Infections; Infections of the urinary system; Urinary tract infections; Urinary Tract Infections; Urinary tract infections caused by enterococci or mixed flora; Urinary tract infections uncomplicated; Urinary tract infections complicated; Infections of the urogenital system; Infections urogenital; Infectious diseases of the urinary tract; Urinary Tract Infection; Urinary tract infection; Urinary system infection; Urinary tract infection; Urinary tract infection; Infection of the urogenital tract; Uncomplicated urinary tract infections; Uncomplicated urinary tract infections; Uncomplicated urinary tract infections; Uncomplicated infections of the genitourinary system; Exacerbation of chronic urinary tract infection; Retrograde kidney infection; Recurrent urinary tract infections; Recurrent urinary tract infections; Recurrent infectious diseases of the urinary tract; Mixed urethral infections; Urogenital infection; Urogenital Infectious-Inflammatory Disease; Urogenital mycoplasmosis; Urologic disease of infectious etiology; Chronic urinary tract infection; Chronic inflammatory diseases of the pelvic organs; Chronic urinary tract infections; Chronic infectious diseases of the urinary system

N40 Hyperplasia of prostate gland: Prostate adenoma; BPH; Prostatauxe; prostate Hypertrophy; Dysuric disorders caused by benign prostatic hyperplasia; Dizuricheskie disorder with benign prostatic hyperplasia; Dysuria with prostate cancer; Benign prostatic giperpalaziya; Benign prostatic hyperplasia; Benign prostatic hyperplasia stages 1 and 2; Benign prostatic hyperplasia I degree; Benign prostatic hyperplasia II degree; Benign prostatic hypertrophy; The disease of the prostate gland; Acute urinary retention related to benign prostatic hyperplasia; Benign prostatic hyperplasia stages 1 and 2 in combination with prostatitis; paradoxical ischuria

N41 Inflammatory diseases of the prostate: Prostatitis; Disease of the prostate; Infection of the genitals; Chronic non-specific prostatitis

N70 Salpingitis and oophoritis: Adnexitis; Inflammatory diseases of female genitalia; Inflammatory diseases of female genital organs; Infection of the genitals; Oophoritis; Acute adnexitis; Salpingitis; Salpingo-oophoritis; Chronic inflammatory diseases of the ovaries; Inflammation of the ovaries

N71 Inflammatory diseases of the uterus other than the cervix: Intrauterine infections; Inflammatory diseases of female genitalia; Inflammatory diseases of female genital organs; Infection of the genitals; Chronic endometriometritis; Chronic inflammatory disease of the uterus; Endometritis; Endometriometry

N74.4 Female pelvic inflammatory disease caused by chlamydia (A56.1 +): Chlamydial salpingitis; Chlamydial infections; Chlamydia

N80 Endometriosis: Endometrioid endometriosis

R68.8.0 * Inflammatory syndrome: Pain syndrome of inflammatory genesis; Pain syndrome with inflammation of non-rheumatic nature; Pain syndrome with inflammatory lesions of the peripheral nervous system; Painful inflammation of the shoulder joint; Painful inflammation after trauma or surgery; Painful inflammation after surgery; Painful hemorrhoidal nodes; Inflammation of the tympanic membrane; Inflammation of the larynx; Inflammation of the gums; Inflammation of cellulose; Inflammation of lymph nodes; Tonsillitis; Inflammation of muscles; Inflammation of soft tissues; Inflammation of the mouth; Inflammation after surgery and trauma; Inflammation after orthopedic surgery; Inflammation after trauma; Inflammation in rheumatoid arthritis; Inflammation of the middle ear; Inflammatory Gum Disease; Inflammatory diseases of the eyelids; Inflammation of the eye; Inflammatory swelling of soft tissues; Inflammatory processes; Inflammatory processes after surgical interventions; Inflammatory process; Inflammatory Syndrome; Inflammatory syndrome of non-rheumatic origin; Inflammatory syndrome after surgery; Purulent infections; Infringements of function of a liver of an inflammatory etiology; Acute inflammation of the musculoskeletal system; Pre-inflammatory soft tissue inflammation

T14.1 Open wound of unspecified body region: Secondary healing processes; Sluggishly granulating wounds; Sluggishly healing wounds; Sluggish wounds; Deep Wounds; Purulent wound; Granulating wounds; Prolonged non-healing wound; Long-lasting non-healing wound and ulcer; Long-lasting non-healing soft tissue wound; Healing of wounds; Wound healing; Capillary bleeding from superficial wounds; Bleeding wound; Radiation Wounds; Slowly epithelializing wounds; Minor cuts; Suppurated wounds; Violation of wound healing processes; Breach of skin integrity; Violations of the integrity of the skin; Violations of the integrity of the skin; Small cuts; Uninfected wounds; Uncomplicated wounds; Operating wound; Primary treatment of surface contaminated wounds; Primary wound treatment; Primary-delayed treatment of wounds; Poorly cicatrizing wound; Poor wound healing; Bad wound; Superficial injury; Superficial wound with mild exudation; Wound; The wound is large; Bite wound; Wound process; Wounds; Wound healing wounds; Stump Wounds; Wounds for gunshot; Wounds with deep cavities; Difficult healing wounds; Difficult wounds; Chronic Wounds

T30 Thermal and chemical burns of unspecified site: Pain syndrome with burns; Pain in burns; Pain with burns; Sluggishly healing post-burn wounds; Deep burns with a wet scab; Deep burns with abundant compartments; Deep burn; Laser burn; Burn; Burn of rectum and perineum; Burn with mild exudation; Burn disease; Burn injury; Superficial burn; Superficial burn of I and II degree; Superficial skin burns; After-burn trophic ulcer and wound; Post-burn complication; Loss of fluid in burns; Sepsis burn; Thermal burns; Thermal skin lesions; Thermal burn; Trophic after-burn ulcers; Chemical burn; Surgical burn

T66 Unspecified radiation effects: Radiation disease; Diarrhea radiation; Gastrointestinal syndrome with irradiation; Radiation sickness; Radiation disorders of mucous membranes; Irradiation chronic; Osteoradionecrosis; Acute radiation sickness; Acute and chronic radiation injuries; Acute radiation syndrome with radiation therapy; Subacute and chronic radiation sickness; Radiation Neuropathy; Radiation edema; Radiation damage to the nervous system; Radiation immunodeficiency; Radiation syndrome; Radio-epileleitis; Radiation acute syndrome; State after irradiation; Cytopenia due to previous radiation or chemotherapy; Cytopenia radiation; Cytopenia due to radiation therapy; Cytopenia due to chemotherapy

T78.4 Unspecified Allergy: Allergic reactions to insulin; Allergic reactions to insect stings; Allergic reactions similar to systemic lupus erythematosus; Allergic diseases; Allergic diseases of mucous membranes; Allergic diseases and conditions resulting from increased release of histamine; Allergic diseases of mucous membranes; Allergic symptoms; Allergic symptoms in the mucous membranes; Allergic reactions; Allergic reactions caused by insect bites; Allergic reactions; Allergic conditions; Allergic laryngeal edema; allergopathy; allergic conditions; Allergy; House dust allergy; Anaphylaxis; Cutaneous reactions to medications; Skin reaction to insect stings; Cosmetic allergy; Drug allergy; Acute allergic reaction; Laryngeal edema allergic genesis and background radiation; Food and drug allergy

T79.3 Post-traumatic wound infection, not elsewhere classified: Inflammation after surgery and trauma; Inflammation after trauma; Secondary infection of skin and mucous membrane damage; Deep Wounds; Purulent wound; Purulent-necrotic phase of wound process; Purulent-septic diseases; Purulent Wounds; Purulent wounds with the presence of deep cavities; Granulating wounds of small size; Disinfection of purulent wounds; Wound infections; Infections wound; Infection of wounds; Infected and non-healing wound; Infected postoperative wound; Infected wound; Infected Skin Wounds; Infected burns; Infected Wounds; Suppurating postoperative wounds; Extensive purulent-necrotic process of soft tissues; Burn infections; Burn infection; Perioperative infection; Poorly healing infected wound; Postoperative and purulent-septic wound; Postoperative wound infection; Wound infection; Wound botulism; Wound infections; Wounds of purulent; Wounds infected; Reinfection of granulating wounds; Sepsis posttraumatic

Y84.2 Abnormal reaction or late complication of the patient without mentioning accidental harm to him during the performance of the radiological procedure and radiation therapy: Radiation therapy of tumors

Z100 * CLASS XXII Surgical practice: Abdominal surgery; adenomectomy; Amputation; Coronary angioplasty; Angioplasty of the carotid arteries; Antiseptic skin treatment for wounds; Antiseptic Hand; Appendectomy; atherectomy; Balloon coronary angioplasty; Vaginal hysterectomy; The coronary bypass; Interventions in the vagina and cervix; Interventions on the bladder; Intervention in the mouth; Restoration and reconstructive surgery; Hand hygiene of medical personnel; Gynecologic surgery; Gynecological intervention; Gynecological surgery; Hypovolemic shock during operations; Disinfection of purulent wounds; Disinfection of wounds edges; Diagnostic intervention; Diagnostic procedures; Cervical Diathermocoagulation; Long-surgery; Replacing the fistula catheters; Infection in orthopedic surgery; Artificial heart valve; cystectomy; Short-term outpatient surgery; Short-term operation; Short surgical procedures; Krikotireotomiya; Blood loss during surgery; Bleeding during surgery and in the postoperative period; Kuldotsentez; laser photocoagulation; laser coagulation; retinal laser coagulation; Laparoscopy; Laparoscopy in Gynecology; CSF fistula; Small gynecological operations; Small surgical procedures; Mastectomy and subsequent plastic; mediastinotomy; Microsurgical operations on the ear; Mukogingivalnye operation; suturing; Minor surgery; neurosurgical operation; Immobilization of the eyeball in ophthalmic surgery; testectomy; pancreatectomy; Perikardektomiya; The period of rehabilitation after surgery; The period of convalescence after surgery; Percutaneous transluminal coronary angioplasty; Pleural thoracentesis; Pneumonia postoperative and posttraumatic; Preparation for surgical procedures; Preparation for surgery; Preparation of the surgeon's hands before surgery; Preparation of the colon for surgical procedures; Postoperative aspiration pneumonia in neurosurgical and thoracic surgery; Postoperative nausea; Postoperative bleeding; postoperative granuloma; postoperative shock; The early postoperative period; myocardial revascularization; Radiectomy; gastric Resection; bowel resection; uterine Resection; liver Resection; enterectomy; Resection of part of the stomach; Reocclusion of the operated vessel; Bonding tissues during surgical procedures; Removal of sutures; Condition after eye surgery; Condition after surgery; Condition after surgery in the nasal cavity; Condition after gastrectomy; Status after resection of the small intestine; Condition after tonsillectomy; Condition after removal of the duodenum; Condition after phlebectomy; Vascular surgery; Splenectomy; Sterilization of surgical instruments; Sterilization of surgical instruments; sternotomy; Dental surgery; Dental intervention in periodontal tissues; strumectomy; Tonsillectomy; Thoracic surgery; Thoracic surgery; total gastrectomy; Transdermal intravascular coronary angioplasty; Transurethral resection; Turbinektomiya; Removal of a tooth; cataract surgery; Removal of cysts; tonsillectomy; Removal of fibroids; Removing the mobile primary teeth; Removing polyps; Removing broken tooth; Removal of the uterus body; Removal of sutures; Fistula likvoroprovodyaschih ways; Frontoetmoidogaymorotomiya; Surgical infection; Surgical treatment of chronic limb ulcers; Surgery; The surgery in the anal area; The surgery on the colon; Surgical practice; The surgical procedure; Surgical interventions; Surgery on the gastrointestinal tract; Surgical procedures on the urinary tract; Surgical procedures on the urinary system; Surgical intervention of the genitourinary system; Surgical procedures on the heart; Surgical manipulation; surgery; Surgery on the veins; Surgical intervention; Vascular surgery; Surgical treatment of thrombosis; Surgery; cholecystectomy; Partial gastric resection; hysterectomy; Percutaneous transluminal coronary angioplasty; Percutaneous transluminal angioplasty; Coronary artery bypass; tooth Extirpation; Extirpation of milk teeth; pulpectomy; pulsative cardiopulmonary bypass; tooth Extraction; teeth Extraction; cataract extraction; Electrocoagulation; endourological intervention; episiotomy; Etmoidotomiya; Complications after tooth extraction

Z51.0 Radiotherapy course: Supplement to external radiation therapy; Local X-Ray Irradiation; Radiation therapy; Brain edema associated with radiation therapy; Lesion in radiation therapy; Radiotherapy

Z51.1 Chemotherapy for neoplasm: Cystitis hemorrhagic, caused by cytostatics; Urotoxicity of cytostatics

Z58.4 Effects of radiation contamination: Radiation damage; Acute radiation damage; Radiation syndrome

Z98.8 Other specified post-surgical conditions: Purulent complications in the postoperative period; Suppurative complications of surgery; Postoperative liver dysfunction; Postoperative vomiting; Postoperative complications; Postoperative period; Early postoperative period

Composition

Solution for intramuscular injection 100 ml

active substance: Sodium deoxyribonucleate 1.5 g

Auxiliary substances: sodium chloride - 0.9 g; Water for injection - up to 100 ml

Description of dosage form

Transparent colorless liquid.

Pharmachologic effect

Mode of action - immunomodulating, wound healing, reparative, regenerating, stimulating hemopoiesis.

Pharmacodynamics

The drug has a modulating effect on the cellular and humoral components of the immune system and the nonspecific resistance of the body, which leads to optimization of the inflammatory response and a specific immune response to bacterial, viral and fungal antigens. The immunomodulating effect of Derinat® is due to its ability to stimulate B-lymphocytes, to activate T-helpers and cells of monocyte-macrophage system. The drug accelerates the energy metabolism inside the cell, the synthesis of RNA and DNA. Activation of cellular immunity with Derinat® increases the ability of natural killers to affect cells infected with viruses, chlamydia, Staphylococcus aureus, Escherichia coli, Helicobacter, etc. Derinat® stimulates reparative and regenerative processes. The drug has anti-inflammatory, antitumor, anti-allergic and detoxifying effects, as well as antioxidant and membrane-stabilizing properties. Derinat® normalizes the state of the body with dystrophies of vascular origin, has a weakly expressed anticoagulant effect.

Derinat® helps to remove free radicals from the body, reduces the sensitivity of cells to the damaging effects of chemotherapeutic drugs.

In the body, the drug accumulates, mainly in the organs of the immune system and hematopoiesis - bone marrow, spleen, lymph nodes, and also in the intestinal epithelium.

Increases the resistance of the body to infections. Stimulates hemopoiesis (normalizing the number of leukocytes, lymphocytes, granulocytes, phagocytes, platelets).

Possessing a pronounced lymphotropic activity, Derinat® stimulates the drainage-detoxification function of the lymphatic system. Derinat® significantly reduces the sensitivity of cells to the damaging effects of chemotherapeutic drugs and radiation therapy.

Has cardioprotective, anti-ischemic and cytoprotective action. With the inclusion of Derinat® in the complex therapy of patients with IHD, the contractile function of the myocardium improves, the death of cardiomyocytes is prevented, tolerance to exercise is increased.

With peptic ulcer of the stomach and duodenum, the drug has a reparative effect, mucosal repair and a pronounced immunomodulatory effect aimed at eliminating the infectious factor Helicobacter pylori.

The drug does not have embryotoxic, teratogenic and carcinogenic effects.

Pharmacokinetics

Suction and distribution

The drug is rapidly absorbed and distributed in organs and tissues with the participation of the endolymphatic pathway of transport. Has a high tropism to the organs of the hematopoietic system, takes an active part in cellular metabolism, integrating into cellular structures. In the phase of intensive drug delivery to the blood, a redistribution occurs between the plasma and the formed elements of the blood, in parallel with the metabolism and excretion. After a one-time injection, all pharmacokinetic curves describing the change in drug concentration in the organs and tissues studied are characterized by a rapid phase of increase and a rapid phase of decrease in the concentration in the time interval of 5-24 hours. T1 / 2 with a / m introduction is 72.3 hours. Derinat ® quickly distributed throughout the body, in the course of daily course use cumulates in organs and tissues: maximum - in the bone marrow, lymph nodes, spleen, thymus; To a lesser extent - in the liver, brain, stomach, small and large intestine. Cmax in the bone marrow is determined 5 hours after the administration of the drug. The drug overcomes the BBB. Cmax drug in the brain is reached after 30 minutes.

Metabolism and excretion

Derinat® is metabolized in the body. Excreted from the body (in the form of metabolites) partially with feces and, to a greater extent, with urine, according to bi-exponential dependence.

Indication of the Derinat

As a part of complex therapy of chronic recurrent inflammatory diseases of various etiology that can not be cured by standard therapy;

Severe course of influenza, acute respiratory infections and their complications (pneumonia, bronchitis, bronchial asthma);

Chronic obstructive pulmonary disease;

In the complex therapy of bacterial and viral infections;

Allergic diseases (allergic rhinitis, bronchial asthma, atopic dermatitis, pollinosis);

For activation of regenerative processes;

Peptic ulcer of the stomach and duodenum, erosive gastroduodenitis;

Urogenital infections (chlamydia, ureaplasmosis, mycoplasmosis, including associated virus-associated infections);

Endometritis, salpingoophoritis, endometriosis, fibroids;

Prostatitis, benign prostatic hyperplasia;

Preoperative and postoperative periods (in surgical practice);

cardiac ischemia;

Trophic ulcers, long-term non-healing wounds;

Obliterating diseases of the vessels of the lower extremities, chronic ischemic disease of the lower extremities of the II and III stages;

Burn disease;

Rheumatoid arthritis, incl. Complicated ARI or ARVI;

Stomatitis, induced by cytostatic therapy;

Odontogenic sepsis, purulent-septic complications;

Mielodepression and resistance to cytostatics in cancer patients, developed against a background of cytostatic and / or radiation therapy (stabilization of hemopoiesis, reduction of cardio- and myelotoxicity of chemotherapy drugs);

Violations of hemopoiesis;

Treatment of radiation damage;

Tuberculosis of the lungs, inflammatory diseases of the respiratory tract;

Secondary immunodeficiency states of various etiologies.

Contraindications

Individual intolerance.

Application in pregnancy and breastfeeding

Consultation of the doctor is necessary. If you need to prescribe the drug during pregnancy, you should evaluate the expected benefit for the mother and the potential risk to the fetus. In the period of lactation, apply strictly according to the doctor's prescription.

Side effects

Patients with diabetes mellitus have a hypoglycemic effect, which should be taken into account by controlling the level of sugar in the blood.

Interaction

The use of Derinat® in complex therapy allows to increase the efficiency and reduce the duration of treatment, with a significant reduction in the doses of antibiotics and antiviral agents with an increase in the periods of remission.

Derinat® increases the effectiveness of antitumor antibiotics of the anthracycline series, cytostatics.

The drug potentiates the therapeutic effect of basic therapy for peptic ulcer of the stomach and duodenum. Derinat® reduces the iatrogenicity of basic drugs in the treatment of rheumatoid arthritis with a 50% and 70% improvement in a number of complex indicators of disease activity.

With surgical sepsis, the introduction of Derinat® in the complex therapy causes a decrease in the level of intoxication, activation of immunity, normalization of hematopoiesis, improves the work of the bodies responsible for the processes of detoxification of the internal environment of the body (including lymph nodes, spleen).

Dosing and Administration

IM.

Adults. Enter for 1 to 2 minutes for 5 ml of a solution of 15 mg / ml (75 mg), with an interval of 24-72 hours.

In acute inflammatory diseases - 3-5 injections with an interval of 24-72 hours.

In chronic inflammatory diseases - 5 injections with an interval of 24 hours, then - 5 injections with an interval of 72 hours.

In gynecology (endometritis, chlamydia, ureaplasmosis, mycoplasmosis, salpingoophoritis, fibroids, endometriosis) - 10 injections with an interval of 24-48 hours.

In urology and andrology (prostatitis, benign prostatic hyperplasia) - 10 injections with an interval of 24-48 hours.

With IHD - 10 injections with an interval of 48-72 hours.

With peptic ulcer of the stomach and duodenum - 5 injections with an interval of 48 hours.

With oncological diseases - 3-10 injections with an interval of 24-72 hours.

With pulmonary tuberculosis - 10-15 injections with an interval of 24-48 hours.

Children prescribe the drug IM in the same way as adults. Children up to 2 years of age, the drug is prescribed in a single dose of 7.5 mg (0.5 ml). In children aged 2 to 10 years, a single dose is calculated based on 0.5 ml of the drug per year of life. Since 10 years of age, a single dose of 5 ml of a solution of 15 mg / ml, the course dose - up to 5 injections of the drug.

Overdose

There were no negative effects from an overdose.

Special instructions

The drug can be administered sc.

IV the introduction of the drug is not allowed.

Release form

Solution for the IM introduction, 15 mg / ml. In bottles of imported glass with injection infusion stopper for 2 or 5 ml. In pallets-blisters for 5 (5 ml) or 10 (2 ml) bottles. In a pack of cardboard 1 pallet-blister.

Manufacturer

CJSC "FI" Technomedservice"

Conditions of supply of pharmacies

On prescription.

Storage conditions of the drug Derinat

In the dark place at a temperature of 4-20 ° C.

Keep out of the reach of children.

Shelf life of the drug Derinat

5 years.

Do not use after the expiry date printed on the package.