Instruction for use: Cyanocobalamin

Trade name: Cyanocobalamin

Trade name of the drug – Cyanocobalamin

International nonproprietary name:Cyanocobalaminum

The name of the active substance in Latin: Cyanocobalaminum

ATC
B03BA01 Cyanocobalamin

Pharmacological groups

- Stimulants hemopoiesis
- Vitamins and vitamin-like agent
The nosological classification (ICD-10)

D50 Iron deficiency anemia
D50.0 Iron deficiency anemia secondary to blood loss (chronic)
D51 Vitamin-B12-deficiency anemia
D52 folic acid deficiency anemia
D64 Other anemias
E53 Deficiency of other B group vitamins
E53.8.0 * Lack of vitamin Bc
E53.8.1 * Lack of vitamin B12
G12.2 Motor neuron disease
G35 Multiple sclerosis
G50 Disorders of trigeminal nerve
G54.1 Disorders of lumbosacral plexus
G60-G64 Polyneuropathy and other disorders of the peripheral nervous system
G80 Cerebral Palsy
G95.9 Disease of spinal cord, unspecified
K73 Chronic hepatitis, not elsewhere classified
K74 fibrosis and cirrhosis
M79.2 Neuralgia and neuritis, unspecified
Q90 Down's syndrome
R68.8 Other specified general symptoms and signs
Structure and Composition
1 ml injection solution contains cyanocobalamin (vitamin B12) 200 or 500 mcg; in 1 ml ampoules, in a cardboard box 10 pcs.

Pharmachologic effect
Mode of action - stimulates cellular metabolism, hematopoietic.

Is involved in the transfer of methyl moieties formation of choline, methionine, creatine, nucleic acids, erythrocytes maturation, promotes accumulation in erythrocytes of compounds containing sulfhydryl groups.
Indications cyanocobalamin preparation 

Anemia (Addison-Birmera, alimentary macrocytic, iron, hemorrhagic, aplastic caused by toxic substances and drugs), cirrhosis, hepatitis, myelosis, polyneuritis, sciatica, trigeminal neuralgia, amyotrophic lateral sclerosis, cerebral palsy, multiple sclerosis, the disease Down syndrome, skin diseases, peripheral nerve injury.
Contraindications
Thromboembolism, angina.
Side effects
Excitement, pain in the heart, tachycardia, and allergic reactions.
Interaction
Incompatible (in the same syringe) with thiamine bromide, riboflavin.
Cyanocobalamin Dosing and Administration
P / to the in / m, in / in and intra-lumbar.
In anemia Addison-Birmera - 100-200 micrograms a day; for anemia Addison-Birmera with symptoms of funicular myelosis and anemia with nervous system disorders - 500 micrograms or more per injection (in the first week of every day, and then - the intervals between injections to 5-7 days). At the same time prescribe folic acid. In remission maintenance therapy is administered to the absence of effects on the funicular myelosis 100 mg 2 times a month, and in the presence of neurological phenomena - 200-400 mg 2-4 times a month.

When iron and hemorrhagic anemia - at 30-100 mg 2-3 times a week; with aplastic anemia (especially in children) - 100 micrograms before clinical and hematological improvement; with nutritional anemia in children at an early age and preterm - 30 mg / day for 15 days.

When CNS diseases and neurological diseases with pain is administered in increasing doses from 200 to 500 micrograms per dose, and in improvement - 100 mcg / day; Course - up to 2 weeks.

In traumatic lesions of peripheral nerves - at 200-400 mcg every other day for 40-45 days.

When hepatitis and cirrhosis of the liver - 30-60 micrograms per day or 100 mg every other day for 25-40 days.

When dystrophy in young children, Down syndrome and cerebral palsy - 15-30 mg a day.

When funicular myelosis, amyotrophic lateral sclerosis, multiple sclerosis is sometimes injected into the spinal canal at 15-30 mcg (gradually increasing the dose to 200-250 mg).
Precautionary measures
When angina should be used with caution and at lower doses.
Cyanocobalamin drug storage conditions
In the dark spot.
Keep out of the reach of children.

The shelf life of the drug Cyanocobalamin
2 years.
Do not use beyond the expiration date printed on the package.