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Instruction for use: Biofer

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Dosage form: Chewing tablets

Active substance: Ferri (III) hydroxydum polymaltosatum+ Acidum folicum


B03AD Iron preparations in combination with folic acid

Pharmacological groups

Stimulants of hemopoiesis in combinations

Macro and trace elements in combinations

The nosological classification (ICD-10)

D50.9 Iron deficiency anemia, unspecified: Iron deficiency anemia; Lack of iron in food; Insufficient absorption of iron from the gastrointestinal tract; Insufficient food intake of iron; Hypochromic iron deficiency anemia; Hypochromic anemia; Iron deficiency anemia in pregnant women; Iron deficiency; Disturbance of absorption of iron from the digestive tract; Combined iron-folic-B12-deficient anemia; Anemia due to violations of hemoglobin synthesis and iron metabolism; Anemia in disorders of iron utilization and reutilization; Impaired iron absorption; Impaired absorption of iron; Insufficient absorption of iron in the digestive tract

E61.1 Insufficiency of iron: Insufficient food intake of iron; Iron deficiency; Iron deficiency in women during pregnancy; Deficiency of iron and folic acid in pregnancy; Iron deficiency after surgery; Latent iron deficiency; Lack of iron during pregnancy and lactation; Inadequate intake of iron from food; Increased need for iron; Increased need for iron during menstruation; Disturbances of iron absorption from the digestive tract; Severe iron deficiency

R58 Bleeding, not elsewhere classified: Abdominal apoplexy; Hemorrhagia; Haemorrhage of the esophagus; Hemorrhage; Generalized bleeding; Diffuse bleeding; Diffuse bleeding; Prolonged bleeding; Blood loss; Blood loss during surgical interventions; Bleeding during surgery and in the postoperative period; Bleeding during labor; Bleeding and haemorrhage in hemophilia B; Bleeding from the gums; Bleeding intraoperative abdominal; Bleeding against a background of coumarin anticoagulants; Hepatic hepatitis; Bleeding in hemophilia A; Bleeding at hemophilia A; Bleeding with inhibitory forms of hemophilia A and B; Bleeding due to leukemia; Bleeding in patients with leukemia; Bleeding; Bleeding due to portal hypertension; Bleeding due to hyperfibrinolysis; Drug bleeding; Local bleeding; Local bleeding due to activation of fibrinolysis; Massive blood loss; Acute blood loss; Parenchymal hemorrhage; Hepatic bleeding; Postoperative hemorrhage; Kidney bleeding; Vascular-platelet hemostasis; Traumatic bleeding; Threatening bleeding; Chronic blood loss

Composition and release form

1 the chewable tablet contains a polymetose complex of iron in an amount equivalent to 100 mg of elemental iron and folic acid 350 μg; In a contour non-jaw-dropping package 10 pcs., In a box 3 packages.


Stable complex of ferric iron and maltose (3-hydroxy-2-methyl-4-pyrone).

Pharmachologic effect

Mode of action - Replenishing deficiency of iron and folic acid, anti-anemia.

Stimulates erythropoiesis. Iron is involved in the synthesis of hemoglobin, myoglobin, cytochrome oxidase, catalase and peroxidase, folic acid in the synthesis of amino acids, nucleic acids, purines and pyrimidines, in the exchange of choline, promotes the normal maturation of megaloblasts and the formation of normoblasts.


After absorption in the gastrointestinal tract, iron binds to plasma transferrin and either is included in synthetic reactions, or is deposited in tissues in the form of ferritin. Excretion of iron occurs with feces, urine and sweat. Folic acid is absorbed mainly in the upper intestine (in the duodenum) and 64% is associated with proteins. It is metabolized in the liver secreted mainly by the kidneys, and also partially by the intestine. T1 / 2 - 22.4 h.

Indication of the drug Biofer

Iron deficiency (prevention and treatment).


Hypersensitivity, hemochromatosis, hemosiderosis, aplastic, hemolytic, sidero-sacral, lead, pernicious anemia, impaired iron absorption.

Side effects

Dyspeptic disorders (nausea, vomiting, constipation, diarrhea, epigastric pain), allergic reactions.


Antacids and tetracycline antibiotics reduce absorption.

Dosing and Administration

Inside, chewing and washing with water.

Prevention - 1 tab. (100 mg of elemental iron) once a day.

Treatment - 1 tab. 2 times a day (under the supervision of a doctor). The course of treatment - 1,5-2 months.


Symptoms: increased side effects.

Treatment: for suspected overdose, determination of serum iron and serum ferritin. With a significant excess of normal indices, the appointment of an iron chelator, deferoxamine, is necessary.

Precautionary measures

At the beginning of treatment it is necessary to examine the serum iron and serum ferritin levels. Treatment is performed until the blood picture is normalized (levels of hemoglobin and serum ferritin).

Special instructions

It is possible to stain the feces in a dark color.

Storage conditions of the drug Biofer

In dry, the dark place at a temperature of no higher than 25 C.

Keep out of the reach of children.

Shelf life of the drug Biofer

3 years.

Do not use after the expiry date printed on the package.

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