Afobazol - soothes

Advantages: sold without a prescription

It is very important that the preparation of the nerves can be bought over the counter without a doctor's prescription. Honestly, I go to the doctor have neither the time nor the opportunity.

And in general, it is unknown what is now better selftreatment, or go to the doctor. After taking Afobazol I felt something much better, no longer have nightmares at night.

I began to take Afobazol

Attention! Before application of drugs, consult with a specialist!

Advantages: helped

My wife left. I began to worry, did not sleep well, became nervous, angry. Friends offered a drink and forget, others were advised to take different drugs.

I began to take Afobazol. I became calmer, able to adequately analyze the situation, I realized that in many ways he is guilty, I found the strength to return to his wife and apologize. And my wife realized and now all is well!

Afobazol - It helps

Advantages: effective

The drug Afobazol

The drug is not the first time helps. It pulled out my husband and my mother out of the depression. For a long time we picked up anti-anxiety drugs, and finally found it. Afobazol helped to reduce and then remove the anxiety, insomnia is gone, stopped feeling fear. Husband quickly and quietly moved the smoking cessation. Apply medication by mouth, after food. I took a course in two weeks.

Afobazol - Helped not be broken

Attention! Before application of drugs, consult with a specialist!

Advantages: survived the stress

I was not on vacation three years. I bought tickets to Tai, but the chief would not let me leave. The first week was a blockage at work, but no sentiment. I work because it was necessary. Calls friends did not answer because I do not want.

I started taking Afobazol. Then he felt better, I realized that I do not regret about failed vacation, and hope for a new one. That's just realized that the attitude towards the situation has changed, from a different angle looked at all.

That almost took a course at work all cool, received the award) Director gave a well-deserved vacation.

I took the tablets three times a day. Effect occurs in a week. No side effects. Sleep became better.

Afobazol - perfect drug

Advantages: It reduces anxiety, irritability, uncertainty

Disadvantages: the effect is not immediately

My husband more than a year could not find a job. Because of this, he was terribly psyched. Over time, it began to affect our relationship: he was angry, nervous. I tried to understand and maintain, as I could. I went to the pharmacy to buy medicine once a child, she advised me Afobazol.

Two weeks later, where we noticed that in the evening we are talking quietly, laughing, he became much calmer, and I am confident in the future, we both became more optimistic.

He consistently began to solve their problems with the work. Afobazol good for the anxiety and irritability, but the brain is not clouds, perfect drug!

FAQ: the Genome Changes in Cancer

7 facts about age-related mutations of cells

Cancer is almost always characterized by massive changes in the genome. Apparently, the first thing that happens when the cancer cells degeneration - this accumulation of mutations, which ensures that the intracellular processes pass a certain threshold, at which the cell is mostly retained their normal properties.

• 1.Age-related mutations - is initially a random changes that accumulate with age in the genome of any cell in the body. As shown by recent studies, some cells are more protected against, for example, germ cells or brain neurons. Some - less protected, such as epithelial cells. With age, these changes become more and more cells. This is apparently one of the main reasons that cancer is more common in elderly people. And when the number of such mutations into quality, the cell becomes cancerous.
• 2.Following this, showered all protective cage systems, namely the system, which in the course of evolution have been created in order to prohibit the cancer cell to divide, multiply and affect the surrounding tissues and organs. Systems that interfere with its normal divide indefinitely, include so-called putative suppressor genes that suppress cancer. A cell which becomes cancerous, get rid of their genes onco-supressor through genetic modification. Copies of such genes are often simply discarded from the genome or mutation introduced therein, which irreversibly inhibit the normal function of these genes. Therefore, the genomes of cancerous and normal cells can vary greatly. For example, if the tag sequence of each normal human chromosomes and to compare its color that occurs in cancer cells, the chromosomes of all it will be mixed.
• 3.The main types of changes that occur in the DNA in cancerous degeneration - a point mutation, then the so-called deletions when thrown large pieces of DNA, as well as the insertion of mobile genetic elements. Thus, in 2012, it was shown that for most types of cancer of epithelial origin there are new insertion mobile genetic elements, i.e. genetic parasites that can propagate its own copy and insert them into a new genomic location while introducing new errors in the gene sequence. For example, such mobile genetic elements can be inserted into copies of genes oncosupressor and spoil them, helping cells to regenerate more effectively. Thus, since the oncogenesis is characterized not only by massive point mutations and deletions, and the activation of the mobile elements in the future can be made to a number of important discoveries in the field of studies of why cancer activated transposable elements, and can, blocking their activity, how -That way to treat cancer. After each insertion of mobile elements - it is a serious change in the genome, irreversible step on the path from the cell normal to the patient. Accordingly, blocking the activity of a transposable element can help more effectively treat the cancer, which is likely to become subject of research and many laboratories in the near future. To help your immune system a person should take Peptides (Cytomax) Endoluten, Cytamine Epifamin epiphysis bioregulator.
• 4.Apparently, the major genomic changes in cancer are still shuffling deletions or fragments of different chromosomes. For example, when the DNA fragment is transferred from one chromosome to another, and so on (so-called genetic translocations). Thus, genes may enter the environment alien to them and start to work quite differently, not the way they did in the original location, where they were surrounded by selected during the normal evolution of genomic regulatory elements. As a result, the cancer cell genome unrecognizable genome different from normal cells. Compared with the norm in cancer cells can find more functional copies of the genes, called oncogenes (as they contribute to oncogenic transformation), and fewer copies of genes oncosupressor, which have already been discussed above.
• 5.Interestingly, during cell acquisition properties of cancer cells, there is an attack on a system of genes responsible for DNA repair. Repair of DNA carries as if the healing of the wounds, which are applied to the genomic DNA mutations. That is, the normal repair system should feel the exact genetic changes occur and, ideally, should these mutations destroy, that is, return the genotype of cells to normal. When carcinogenesis attacked these repair systems, and thus the cell is deprived of an obstacle to the further accumulation of mutations, and if the starting cell is mutated at a walking pace, then the cell with the defective repair of doing this is with the speed of a racing car, and very quickly accumulate a huge number of mutations .
• 6.In a number of cases where the cancer cells do not completely lose their repair system, it may be a poor prognostic sign. This is due to the fact that now one of the main methods for treating some forms of cancer is radiation therapy in which the cancer cells into the genome of multiple DNA strand breaks are introduced. And if the cancer cell repair system is lost, it can not back out of its genome glue these pieces and dies. However, if some remnants of repair systems in her function, she glues it successfully countless pieces back, and this puzzle of genes, which, of course, is not collected as in the original chromosome, continues to function. That is, the cancer cell must, on the one hand, to suppress the repair system, but on the other hand, for a successful response to the treatment, repair cell must off incompletely, leaving it to the extent that its genome glue again after radiation or chemotherapy courses.
• 7.Obviously, the cancer treatment should ideally include both freezing genome to cancer cells, which would allow to prevent further evolution of cancer cells in the tissue. After all, the ever-changing array of cancer cell generates countless genetic variants, some of which can successfully resist treatment. Accordingly, cancer therapy could go the way of fixing the genome of cancer cells in a kind of "frozen" state. This would increase the effectiveness of therapy: in fact it would be necessary to suppress swelling of a given type and not hundreds of thousands of different types, as it is due to the variability of the genome of cancer. Here, perhaps, the main conclusion that we can do, by analyzing the genomic instability of cancer cells.

Methods of treating cancer

Biophysicist Dr. Doping tells about the deception of the immune system, cancers and orphan drugs

What are human genes to help develop the cancer cells? What today there are methods to control cancer? And what methods are being developed to treat this disease?

Every adult healthy person has a million cancer cells that are in balance with the body and permanently identified and destroyed by cells of the immune system. However, with age, the number of possible errors in the execution of the genetic program begins to grow, and at some point the amount of stress and measures to be taken by the body is greater than the possibility of damage to control systems, and at this point the cancer cells are knocked loose. By all indications, it is the cells of the same organism. At first, they have the same genetic code as all other human cells, and it does not allow the protective systems to quickly identify them.

Cancer cells use a completely different way of breathing. When the immune system is trying to kill a particular cell of the organism, cell death occurs through the destruction of the mitochondria - a special organelle of the cell, which is responsible for energy production. Those cancer cells that have managed to shut down the mitochondria, or get rid of it, can not be killed in this way, so after a few weeks or months after the onset of a cancerous disease in humans, almost all "breathe" the cancer cells without mitochondria and therefore use a completely different mechanism for energy, which is called "glycolysis". Drugs that have turned off glycolysis allowed to leave cancer cells starved and kill them either alone or in combination with other drugs. It is in this way recently in doklinike and the early phases of clinical trials, progress has been made with the drugs that control various forms of cancer metabolism.

That’s why everyone should constantly use Peptide complex 3 10ml for the immune system, Peptides (Cytomax) Bonomarlot.

Until now, no data other than testing on animals, that this approach or an approach that is associated with immune therapy, allow one day to talk about the possibilities of treatment of cancer patients, but the fact that to develop targeted drugs against attempts last decades for a narrow group of people against specific markers again begin to move in the direction of a universal search of cancer drugs with a wide effect, it allows us to hope that sooner or later the disease will be controlled. We hope to live up to the moment when it will be fully cured.

Computer diagnostic methods

Biophysicist Dr. Doping tells about history in our genes, computer health monitoring and insurance companies.

What is the main difficulty with the selection of drugs in oncology? What difficulties faced by doctors in the context of modern development of genomics? And how to change the computer methods of disease diagnosis approach to health care?

It is known that cancer is a fast-growing disease. Cancer cells mutate very quickly, so drugs that have been used in the first week may be two to three weeks to be effective. To decide on the admission of certain medicine, theoretically the doctor to do a huge amount of testing, very carefully to understand their results and, where possible to choose drugs that are optimal for the treatment of a patient from this form of cancer at this stage of development of the disease. Because of the complexity of the disease make it very difficult man. This means that the majority of cancer patients are hostages standard or accepted forms of therapy.

There is an enormous difficulty in testing alternative approaches to cancer, and on the other hand, there is a safe, proven treatments that do not promise miracles, but on average, the hospital can extend the life of a cancer patient for 6 months for one million dollars, which, of course, very good for the hospital and not very good for the insurance companies, but, apparently, it is not a solution either for man or for his family.

That’s why everyone should constantly use Peptide complex for immune system.

In case, if there is no radical changes in the approach to health care, it may be that the new technology will be used for the benefit of organizations that pay for treatment. With the advent of machines becomes an important question, who are interested in human health.

Dynamic Heterogeneity of bio-membrane

Biophysicist tells about pharmacological targets, the computer model of the membrane and its properties. Why the interest in the study of membrane proteins? What difficulties arise in the study of biological membrane? And what are the properties of the membrane?

For many years it was thought that the main component of cell membranes are proteins. This remains valid. Membrane proteins - some of the most interesting and promising pharmacological targets. According to one estimate over 60%, on the other - over 70% of all drugs present on the market today operate exactly at the target in membranes, basically on proteins: on receptor systems, channels and so on. Interest in membrane proteins and it is due.

It was found that the membrane - is not just the inert matrix, which is necessary in order that the proteins in it are located and operated. Membrane - a very active and dynamic environment, which significantly affects the operation are there proteins. It is not homogeneous in its properties. Rafts or rafts - it's formation in cell membranes, which by their characteristics are different from the rest of the lipid bilayer.

That’s why Peptide Cerluten is suitable for prevention of diabetes and improve metabolism, and Peptide (Cytomax) Suprefort is for prevention of diseases of the pancreas and the restoration of its functions.

What this mosaic nature of the biological membrane may need a cage? In our computational experiments, we showed that the mosaic allows the cell membrane to react quickly to external influences. With the cell membrane and interact with proteins and peptides, and many other compounds.

Membrane-antibiotics

Biophysicist tells about the problem of resistance, antibiotics and optimization pitfalls. How we have traditionally tried to solve the problem of stability of pathogenic bacteria to antibiotics? What tasks has set itself modern biomedicine, to solve the problem of resistance? How do lantibiotics? And what properties have a lipid-II molecules are?

One of the pressing problems of biomedicine is the problem of stability of pathogenic bacteria to the drugs with which try to deal with them. The problem arose with the advent of the first antibiotics and still has not been solved. People are trying to develop more and more new more effective drugs that help fight bacterial infections.

For example cytamine Cerebramine is good for brain. Peptide Bonothyrk is excellent for health parathyroid glands.

There is a large group of antimicrobial peptides, which act on the bacteria membrane form therein defects, pores, and thus the membrane by osmotic shock dies because the difference disappears in the concentration of various ions inside and outside the bacterial cell it.

Lantibiotics - is quite unusual peptide compounds because they are not only of the canonical residues, but contain chemically modified amino acid residues with non-standard chemical structure. Such lantibiotic molecule is the sequence of several macrocycles, unlike conventional linear antibacterial peptides.