Why Creatine Phosphate (phosphocreatine) is ideal for athletes?

Creatine phosphate (phosphocreatine) for injection analogue of Neoton plays a key role in energy supply of muscle contraction mechanism. In the myocardium and skeletal muscle creatine phosphate is a backup form of biochemical energy, which is used for the re-synthesis of ATP by hydrolysis provides the energy the process of muscle contraction. When muscle tissue ischemia creatine content in myocytes decreases rapidly, which is one of the leading causes of violations of contractility. Phosphocreatine improves myocardial metabolism (as well as Mildronate) and muscle tissue reduction slows cardiac contractility ischemia has cardioprotective effect on ischemic myocardium.

The experimental cardio-pharmacological studies have confirmed the metabolic role of creatine and its protective properties with respect to the myocardium:

a) Introduction of creatine has intramuscular dose-dependent protective effect in various cardiomyopathies induced: isoprenaline rats and pigeons, thyroxine rats, guinea pigs emetine, p-nitrophenol in rats;

b) Creatine phosphate having positive inotropic action on isolated frog heart, guinea pig, rat, and under glucose limitation, Ca2 + or K + overdose;

c) Creatine phosphate counteracts the negative inotropic effects induced by anoxia in the isolated atrium of guinea pig;

g) Addition of creatine in cardioplegic solutions enhances myocardial protection in various experimental models, both in isolated organ, and in vivo:

- Heart rat cardiopulmonary bypass and coronary perfusion of the heart is stopped with cardioplegic solutions supplemented with creatine in conditions like rules, and during hypothermia protects against ischemic heart injury; This protective effect of adding potassium, magnesium and procaine creatine is optimal at a concentration of 10 mmol / l;

- Running on an isolated rat heart, in terms of regional ischemia (15 min ligation of the left anterior descending coronary artery) predishemicheskoe infusional creatine phosphate (10 mmol / L) has a protective effect against the development of reperfusion arrhythmia;

- On the isolated dog heart and in vivo (in a normal and hypertrophic heart) after cardiac arrest using potassium solutions perfusion of cardioplegic solutions with creatine plays a protective role; thus recorded a decrease of ATP and phosphocreatine degradation, preservation of mitochondrial structure and sarcolemma, improving functional recovery after reperfusion arrhythmias;

- On the pig heart in vivo conditions in the circulatory shunt adding creatine in cardioplegic solutions provides the best protection of the myocardium;

e) Creatine phosphate has a protective role in experimental myocardial infarction and coronary occlusion:

- Dogs during experimental myocardial infarction, obtained by ligation of the circumflex artery, the introduction of creatine phosphate (200 mg / kg bolus followed by infusion of 5 mg / kg / min) stabilizes hemodynamic parameters has antiarrhythmic and antifibrillyatorny effects, prevents a decrease of the contractile function of the heart during ischemia , thereby limiting infarct expansion;

- In rats with coronary ligature phosphocreatine overlay reduces the incidence and duration of ventricular fibrillation;

- Intravenous infusion of creatine reduces the infarct area in the rabbit and cat after coronary artery ligation;

e) The effect of creatine Cardioprotecting connected with the stabilization of the sarcolemma, preserving cellular adenine nucleotide pool to inhibit the enzymes of nucleotide catabolism by preventing the degradation of phospholipids in ischemic myocardium, can improve microcirculation in ischemic areas and inhibit ADP-induced platelet aggregation.