Veroshpiron (Spironolactone)

Veroshpiron (Spironolactone)

Pharmacological group: diuretics; diuretics; potassium-sparing diuretics.
Pharmacological action: Potassium-sparing diuretics, the effect of which is due to antagonism of aldosterone.

Description

Veroshpiron is an aldosterone antagonist in the pharmaceutical industry is classified as a diuretic. The drug acts competitively inhibiting aldosterone binding to receptors, particularly in renal tubules, wherein the aldosterone participated in the potassium-sodium exchange. It causes an increase in amount of drug eluted from the body of sodium and water, while keeping potassium stocks. This differs from some other Veroshpiron diuretic drug class, such as loop diuretics such as furosemide, which can greatly enhance the excretion of sodium, potassium and water. In light of this, Veroshpiron commonly called "potassium-sparing" diuretic. It is used in medicine, in some cases, including for the treatment of high blood pressure, edema associated with congestive heart failure, hyperaldosteronism (overproduction of aldosterone) and hypokalemia (lowering potassium levels are often associated with other health interventions). Veroshpiron commonly used (off-label) professional athletes and bodybuilders for short-term correction fluid volume in the body and improve muscle definition or correction of weight before a competition in sports that require certain restrictions on the weight categories.

History
Veroshpiron was developed in the late 1950s, and the first time has been widely used in clinical medicine in the early 1960s. The drug is marketed as a diuretic, potassium is not destructive and, therefore, has a less negative impact on the electrolyte balance in the body. The drug is in many respects is considered "safe" and "soft" diuretic, compared with other products of this category, such as loop diuretics, thiazide or means. Today Spironolactone is widespread in most of the developed countries of the world. The drug is available under a dozen brands, the most famous of which is considered Aldactone by Searle Company. Also widespread drugs, including in the structure other diuretics, such as furosemide or hydrochlorothiazide Lasilacton product in Aldactazide product.

Structural Features
Spironolactone is an aldosterone antagonist and a diuretic. It has the chemical name 17-hydroxy-7alfamerkapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid y-lactone acetate. Warnings (dehydration, elevated potassium levels, mortality) Abuse of diuretics in order to improve the physique or performance is characterized by a high degree of risk. The use of diuretics without proper medical supervision can lead to life-threatening level of dehydration and electrolyte imbalance. Abuse of these drugs is associated significant risk of death. It is also important to note that during the reception of potassium-sparing diuretics such as spironolactone, usually not recommended to use potassium supplements or pharmaceutical products rich in potassium. Excessive potassium intake may cause hyperkalemia, characterized by an increased risk of arrhythmia and mortality. You can also like Ovagen.

Veroshpiron: side effects
Adverse reactions associated with the use of veroshpiron may include: gynecomastia, cramps, diarrhea, drowsiness, lethargy, headache, skin irritation, rash, confusion, fever, impotence, loss of muscle coordination, menstrual irregularities, virilization and deepening of vote. It was also shown that may contribute Veroshpiron tumors in rats. Some patients taking Veroshpiron, there is the development of breast cancer, but has not yet been established causal link with cancer veroshpiron. In addition, the compound may be antiandrogenic properties, acting weak inhibitor of the binding of androgens to the receptor and testosterone biosynthesis.

Veroshpiron application
In medicine, for the treatment of hypertension, the recommended starting dose for adults is veroshpiron from 50 mg to 100 mg per day in separate doses. Waiting for the body's response may take a maximum of two weeks. The dose is adjusted depending on the individual patient's needs. Male bodybuilders use the drug (not on purpose) To increase muscle relief or to reduce weight before weighing, often at a dose of 100 mg per day in the morning. The drug is taken for 3-5 days before the event. The drug helps to eliminate excess fluid from the body, resulting in a more pronounced muscle relief (or there is a significant decrease in body weight). Women Veroshpiron rarely used as an anti-androgen. The drug is sometimes used if the androgen level in the cycle reaches a critical point, and it is necessary to reduce the risk of virilizing symptoms. For these purposes, frequently used dosage of 25-75 mg daily for 1-2 weeks, may be sufficient to prevent the adverse effects while reducing the level of androgens (the termination of steroid therapy). Since Veroshpiron more effective to reduce endogenous levels of androgens than to inhibit the action of androgens, it certainly can not be regarded as a cure-all for the athletes who abuse steroids. Since the compound is one of the softest (Rx), diuretics, most often it is used by novice competitive athletes. Having clarified for all the consequences of its use, many are trying to achieve a stronger loss of fluid by mixing veroshpiron with thiazides or furosemide (Lasix). The purpose is to provide a strong water separation with smaller losses of potassium and calcium than using strong diuretics. For example, when mixed with the hydrochlorothiazide dose veroshpiron B100 mg are often divided into two parts, taking an equal amount of thiazides. When receiving the combination of 50 mg / 50 mg noticeable increase in excretion of water without severe side effects. potassium reabsorption in the application veroshpiron balanced of thiazides. On the other hand, Lasix (furosemide) appears even stronger complement veroshpiron. In this case veroshpiron often reduce the dose to 50 mg or 20 mg of oral added Lasix that provides fluid loss effect approximately equivalent to 40 mg Lasix tablet. Again, the decrease in the level of potassium (a side effect of Lasix) may be somewhat balanced potassium-sparing effect veroshpiron. Widely available various combinations of diuretics with support in the scientific community. It is important to note that, while Lasix Gidrodiuril and more effective for the induction of short-term loss of fluid, they also have an increased risk compared with potassium-sparing diuretics, and their use should be approached with caution.