Transcription and genetic diseases

Geneticist Dr. Doping tells about crash in transcriptional regulation, tumor cells and the development of new drugs. What changes in the human genome lead to disease? How recent studies of gene transcription can help in the treatment of cancer?

The transcription factors control the expression of genes in approximately half of any cell type. We have come to realize that a huge part of the variations in the human genome associated with the disease actually affects the transcriptional control of the state in many cells of interest for medicine cells. This is the basis upon which we want to understand how these changes in the genome cause failures in the regulation of transcription, which leads to disease. To find out, we studied cells as an example, cancer patients. Tumor cells often carry out the changes, experiments with its genome. Thus, they are modified, mutated, in the selection of them can give a survival advantage.

We found that the super-enhancers that create cells for the overexpression of oncogenes basic, are very sensitive to drugs aimed at many of the transcriptional machinery. We did not expect this, but we believe that it is particularly vulnerable tumor cells. Already there and developed a lot of drugs that specifically affect either the transcription cofactors or the chromatin regulators, which seems to confirm the particular sensitivity of tumor cells to this type of medication due to the vulnerability of the super-enhancers.

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One area of potential drugs suitable for the invention, is associated with transcriptional co-factors that are involved in histone modifications and histone binding to transcription factors are optional. Many of these substances are enzymes that modify the various components of the transcription machinery, or histones from the immediate environment. This invention is suitable for drugs, because they are active, potentially useful for drug development, and determine how to react to develop the structure or activity of the small molecules for clinical use.