Topiramat (Topamax)

The new direction in drug treatment of an obesity is use of the topiramat (topamax) used in the USA as an anti-epileptic agent. Multicenter clinical tests of topiramat at patients with an obesity are carried out (without epilepsy) during which it is proved that it authentically loses weight and the ABP level. Drug was especially effective at patients with pathological types of alimentary behavior: at compulsive alimentary behavior, emotsiogen alimentary behavior, a syndrome of "night" food and the panic attacks. Officially topamax is still intended only for treatment of an epilepsy. The combination of an epilepsy and an obesity can be the special indication to purpose of topiramat, considering that circumstance that other anti-epileptic drugs can increase weight at 50% of patients.

Use

Topiramat for weight reduction begin to accept with a dose 25 mg a day, then increase to clinically effective dose 25 mg each two weeks. The average daily dose usually makes 200 mg a day in two steps, duration of a therapeutic course of 14 weeks. Need of titration of a dose is bound to possible emergence of side effects the main of them parenthesis, dryness in a mouth and headaches . You can also like Tiramin.

Treatment of obesity at patients with diabetes mellitus

At reception of topiramat reliable depression of body weight and appreciable depression of level of HbA1c hemoglobin and arterial pressure at the patients with a diabetes mellitus of the 2nd type having obesity who accepted the treatment consisting in keeping of a diet and performance of physical exercises or in a combination of these methods with mono therapy by Metforminum earlier is shown. However side effects of drug from a CNS and the mental sphere make impossible use of topiramat for treatment of patients with obesity and diabetes mellitus.