The survivin protein in oncogenesis

Molecular biologist Dr. Doping tells about apoptosis of tumor cells, the early diagnosis of cancer and the blockage of survivin function. There is a difference in the expression of survivin protein in tumor cells and normal? Does this protein diagnostic value? What are the prospects for its blocking in the treatment of tumors?

In the early 90-ies of the survivin protein was discovered. It was opened as a protein inhibitor of apoptosis. It appears that it is blocked apoptosis in tumor cells. Tumor cells have to die, but as they increased the number of apoptosis protein inhibitor, the cell does not die, it continues to grow and multiply. Survivin protein encoded by a gene called BIRC-5. In our Institute of Bioorganic Chemistry of the MM Shemyakin-Ovchinnikov Ovchinnikov, RAS was performed subtractive hybridization study the transcriptome of tumor and normal cells have been shown differences in the expression of different genes in the tumor cells and normal. Gene BIRC-5 did have an increased expression in tumor cells. Next, the path has been done in the study of the gene and its product - protein survivin and laboratories around the world have shown that survivin protein often found in elevated levels in nearly all tumor types. As a result, the protein survivin was among the five most important tumor markers. This protein is a diagnostic marker.

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It has previously been shown that the protein survivin in the cells acts as a dimer. This is true, and it's a good fit for the protein survivin in the formation of microtubules and protein as a set of chromosomes passengers. However, in 2011 year we have shown that survivin protein monomer is the most important and shows apoptotic properties.

Further studies of the protein associated with the fact that the small molecules are sought that could interact with the protein and block its function. It would be great if these small molecules bind to the monomeric form of survivin, thereby blocking its function is anti-apoptotic, and would not affect other functions of the protein.