The polypeptide neurotoxins and receptors: Yesterday and Today

Pharmacologist Dr. Doping tells about the importance of nicotinic receptors, the kinds of neurotoxins and proteomic studies. What are nicotine receptors? What are the physiological functions of acetylcholine binding protein? Is it possible to combine basic science and business?

Nicotinic receptors are involved in pain signal transmission. They play an important role as a neuroprotective. Regulation of the immune response, the control of cell growth, including the effects on the malignant growth - it is largely fulfill certain subtypes of nicotinic receptors are found on cells of the immune system.

If nicotinic receptors that something is wrong, it is expressed in a variety of diseases. Myasthenia gravis - one of the reasons for the formation of autoantibodies against muscle receptors. Some types of epilepsy - mutations in neuronal alpha-4 receptor. Some types of schizophrenia - the lack of expression of the alpha-7 receptors.

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Parkinson's disease and Alzheimer's disease. Of course, there nicotinic receptors are not the most important players. However, these diseases are always disturbed cognitive function. Always one of the first to suffer the cholinergic system, ie nicotinic receptors then partners. With nicotine dependence is clear: nicotinic receptors main culprits here.