Targeted drug delivery

Chemist Dr. Doping tells about the "magic bullet", the effects of chemotherapy and the drug development process.What are the challenges faced by scientists working on the problem of targeted drug delivery? What are the prospects for the development of medicines? And what will the region develop targeted therapies?

The traditional approach in any chemotherapy, whether chronic or acute disease - is a drug which improves the state of the patient, because it acts on the ailing tissue or organ, or circulate in the bloodstream, is distributed on the human body both in healthy and in the affected tissue. Of course, most drugs have side effects because of the fact that they are in the systemic circulation, that is not much work selectively targeted, as desired.

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One of the trends, emerging today in biomedicine, very best including from chemistry, biology and medicine - is Targeted or targeted delivery of medications, drugs only in the affected organs and tissues. This idea is quite old and first appeared at the Paul Ehrlich, who called it "magic bullet" or "magic bullet" that would hit only those organisms or organs, which need to be cured.

Most pathological tissues in the body, those who are sick, for example, cancer cells differ from healthy cells by the receptors, that they have on the surface, by the way they behave metabolically, ie they are not exactly the same, even at the very beginning disease. If we, from a biological point of view, to know what these cells differ from healthy, and can be chemically synthesized compound, or a certain drug delivery systems are known only in these specific tissues, it would be very good.