Sperm-specific proteins and Oncology

Molecular biologist Dr. Doping tells about synthesis of specific proteins, enzymes associated with melanoma, and the role of inhibitors in the treatment of cancer.How do synthesize specific proteins? What is an enzyme associated with melanoma? How do sperm-specific proteins can be used in the diagnosis and treatment of cancer?

Specialized cells such as sperm cells and some other special synthesize proteins that are needed for different functions. For example, a sperm function may be the synthesis of proteins to build the tail, which it moves, and special enzymes that are necessary for the penetration of sperm into the egg. Thus, there is a set of proteins that is specific only for the sperm. All tissues differ from one another but different degree of specificity. For example, liver cells, the cells closer to the heart than brain cells and sperm. However, fabrics which are responsible for the photoreception such as the retina, have too many special proteins that are associated with processes photoreception. Under normal circumstances, in normal somatic cells, proteins that are specific to the retina or sperm, never produced. A different situation arises when we develop cancer.

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Sperm-specific protein glyceraldehyde-3-phosphate - a glycolytic enzyme which is synthesized in the melanoma cells and melanoma - oncological disease is severe. The cells metastasize very quickly, and the death rate from this cancer is quite large. It has been shown that in these cells, in some lines, suddenly begins to synthesize an enzyme that is normally only typical sperm. Therefore, the sperm-specific proteins or retino-specific proteins may be used for diagnosis at least. There are two groups of tumor markers, by which to identify certain types of cancers. It is clear that not all cancers will be produced these proteins, but can be screened for various cancers and determine which proteins are produced.

It is necessary to study how the metabolism, differentiation of cancer cells after they start to produce proteins that are not typical for them. Perhaps, some specific features of cancer cells and is connected with this. It is possible that it is this - one of the ways of treating cancer, because if we pick the compound inhibitors that will selectively switch off from work, for example, zoospermatic enzyme, but do not act on somatic, then maybe we will be able to selectively kill cancer cells without compromising normal somatic cells.