Sermion (Nicergoline) tablets - Instructions for Use, Dosage, Side Effects, Reviews

Synonyms: Acerine, Adavin, Albotyl, Bieluzon S, Bolinon, Ceborin, Ceramon, Cereline, Cergodun, Cergoline, Chen Rang, Cholergol, Circulat, Ergobel, Ergotop, Eshinole, Fitergol (veterinary use), Fulutong, Ibunein, Jin Yi Xin, Kai Er, Lestmart N, Lexilin, Marileon N, Marion, Meilisu, Micermion, Nergolin, Nicer, Nicerbium, Nicergin, Nicergobeta, Nicergolin Towa Yakuhin, Nicergolin, Nicergolina Angenerico, Nicergolina EG, Nicergolina LPH, Nicergolina Sandoz, Nicergolin-CT, Nicergoline Biogaran, Nicergoline EG, Nicergoline Mylan, Nicergoline Ranbaxy, Nicergoline Teva, Nicergoline-SaiKe Pharm, Nicergolin-neuraxpharm, Nicerin, Nicerium, Nicerium uno, Nicerline, Niclostin, Nigoline, Nilogrin, Nixo, Qualigoline, Sawachion, Selphamin, Sermion Bb Farma, Sermion Programmi Sanitari, Sermion, Serolin, Seromin, Shi Nuo Da, Sinergolin, Sinja, Socwarl N, Varson, Vasogoline S, Wincl N, Ya Run Ji.

Active substance: Nicergoline.

ATC - C04AE02 Nicergoline.

Pharmacological group – Alpha-blockers; Cerebrovascular correctors.

Nicergoline (INN, marketed under the trade name Sermion) is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs.

It is used for vascular disorders such as cerebral thrombosis and atherosclerosis, arterial blockages in the limbs, Raynaud's disease, vascular migraines, and retinopathy. You can buy Sermion.

Nicergoline has been registered in over fifty countries and has been used for more than three decades for the treatment of cognitive, affective, and behavioral disorders of older people.

Nosological classification (ICD–10)

F01 Vascular dementia;

G44.1 Vascular headache, not elsewhere classified;

G45 Transient transient cerebral ischemic attacks [ attack ] and related syndromes;

G46 Vascular syndromes of brain in cerebrovascular diseases;

G93.9 defeat brain, unspecified;

I10 Essential (primary ) hypertension;

I15 Secondary hypertension;

I63 Cerebral infarction;

I66.9 Occlusion and stenosis of unspecified cerebral artery;

I67.2 Cerebral atherosclerosis;

I73.0 Raynaud’s syndrome;

I73.8 Other specified peripheral vascular disease;

I73.9 peripheral vascular disease, unspecified.

Sermion (Nicergoline) Composition, structure and packing

Tablets, coated orange, round, convex.

Sermion (Nicergoline) Pharmacological action

Drug improving cerebral and peripheral circulation, alpha-blocker. Nicergoline - derivative ergoline improves metabolic and hemodynamic processes in the brain. Reduces platelet aggregation and improves the rheological parameters of blood, increases the rate of blood flow in the upper and lower extremities. Has alpha 1-adrenoceptor blocking action that causes blood flow improvement. Has a direct effect on cerebral neurotransmitter systems - noradrenrergic, dopaminergic and atsetilholinergic. Against the background of the drug increases the activity of dopaminergic and noradrenergic atsetilholinergic cerebral systems that helps to optimize cognitive processes. As a result, long-term therapy Nicergoline observed sustained improvements in cognitive function and decrease the severity of behavioral disturbances associated with dementia.

Pharmacokinetics

Absorption

After ingestion, nicergoline rapidly and almost completely absorbed.

Food intake or dosage form do not significantly affect the extent and rate of absorption of nicergoline. Pharmacokinetics nicergoline when used in doses up to 60 mg is linear and does not vary depending on the age of the patient.

Distribution and metabolism

Nicergoline active (> 90%) binds to plasma proteins, and its degree of affinity for the α-acid glycoprotein more than a serum albumin. It is shown that nicergoline and its metabolites can be distributed in the blood cells.

Major metabolites nicergoline: 1,6-dimethyl–8β-hydroxymethyl–10α-metoksiergolin (MMDL, hydrolysis product) and 6-methyl–8β-hydroxymethyl–10α-metoksiergolin (MDL, demethylation by the action of a product isozyme CYP2D6).

Ratio of AUC values for MMDL and MDL ingestion and/introduction Nicergoline indicates pronounced metabolism in the “first pass” through the liver. After receiving 30 mg of nicergoline inside C max MMDL (21 ± 14 ng/ml) MDL (41 ± 14 ng/ml) were achieved after approximately 1 and 4 hours, respectively, and then decreased with the concentration of MDL T 1/2 13–20 hr studies confirm the absence of accumulation of other metabolites (including MMDL) in the blood.

Breeding

Nicergoline is displayed in the form of metabolites, mainly in the urine (approx. 80% of the total dose) in a small amount (10–20%) - from the feces.

Pharmacokinetics in special clinical situations

In patients with severe renal impairment showed a significant decrease in the degree of removal of metabolic products with urine compared with patients with normal renal function.

Sermion (Nicergoline) Dosage

The drug is prescribed inside.

In chronic cerebral circulatory disorders, vascular cognitive impairment, post-stroke states Sermion appoint 10 mg 3 times/day. The therapeutic effect of the drug develops gradually and course of treatment should be at least 3 months.

Vascular dementia appoint 30 mg 2 times/day. In this case the patient is recommended every 6 months to consult with your doctor about whether to continue therapy.

In acute cerebral circulatory disorders, ischemic stroke due to atherosclerosis, thrombosis and embolism of cerebral vessels, transient ischemic attack (transient ischemic attack, cerebral hypertensive crises) is preferable to start treatment with parenteral administration of nicergoline, then continue taking the drug inside.

When peripheral blood flow disorders Sermion appoint 10 mg 3 times/day for a long time (several months).

Patients with impaired renal function (serum creatinine content of> 2 mg/dL) Sermion recommended for lower therapeutic doses.

Sermion (Nicergoline) Overdose

Symptoms: transient marked reduction in blood pressure.

Treatment: special treatment is usually not required, a patient for a few minutes is sufficient to take a horizontal position. In exceptional cases, the sudden circulatory disorders of the brain and heart recommend the introduction of sympathomimetic funds under constant control of blood pressure.

Sermion (Nicergoline) Drug Interactions

With simultaneous use may increase the effects Sermion antihypertensives.

Nicergoline metabolized by the action of isoenzyme CYP2D6, so we can not exclude the possibility of interaction sermion with drugs that are metabolized with the participation of the same enzyme.

With simultaneous use of nicergoline with acetylsalicylic acid may increase bleeding time.

Sermion (Nicergoline) at Pregnancy and lactation

In the absence of specific studies in pregnancy Sermion should be used only on strict conditions and under the direct supervision of a physician.

While taking the drug should abandon breastfeeding because nicergoline and its metabolites are excreted in breast milk.

Sermion (Nicergoline) Side effects

With the cardiovascular system: rarely - marked reduction in blood pressure (mainly after parenteral administration), dizziness, sensation of heat.

The nervous system: rarely - drowsiness or insomnia.

From a metabolism: may increase the concentration of uric acid in the blood, and this effect was not dose-dependent and duration of therapy.

Other: rarely - dyspepsia, skin rashes.

Side effects are usually easy or moderately expressed.

Sermion (Nicergoline) Indications

Acute and chronic cerebral metabolic and vascular disorders (due to atherosclerosis, hypertension, thrombosis or cerebral embolism, including acute transient ischemic attack, vascular dementia, and headache caused by vasospasm);

Acute and chronic peripheral metabolic and vascular disorders (organic and functional limb arteriopathy, Raynaud’s disease, symptoms caused by disturbance of peripheral blood flow).

Sermion (Nicergoline) Contraindications

Recent acute myocardial infarction;

Severe bleeding;

Bradycardia;

Violation of orthostatic regulation;

Lack of sucrase/isomaltase, intolerance fructose, glucose-galactose malabsorption;

Age 18 years;

Pregnancy;

Lactation (breastfeeding);

Hypersensitivity to the drug.

Caution should be used for hyperuricemia or gout history and/or in combination with drugs that disrupt metabolism and/or excretion of uric acid.

Sermion (Nicergoline) Cautions

At therapeutic doses, Sermion, usually does not affect the blood pressure, however, in patients with hypertension, it may cause a gradual reduction in blood pressure.

The drug acts slowly, so it should be taken for a long time, and the physician should periodically (at least every 6 months) to evaluate the effect of treatment and if it should be continued.

Effects on ability to drive vehicles and management mechanisms

Despite the fact that Sermion improves concentration, the effect of the drug on the ability to drive vehicles and use machines has never been studied. Given the nature of the underlying disease, caution should be exercised in patients with potentially hazardous activities.

Sermion (Nicergoline) Reviews

Samantha, 27 years, Sermion - drug accelerated speech development in the child.

Advantages:
It stimulates mental activity, improves cerebral blood circulation

I want to share with you the effect of the use of the drug Sermion assigned to my child neurologist.
At the time of Sirmione little son was 1 year and 10 months. We turned to the neurologist with the following problem. The child is a lot of walking on tiptoe. When reminded him walking on heels, baby takes a few steps stepping on heels, and then again rising on tiptoes. The neurologist said that it is a consequence of the strong tone of the leg muscles and high intracranial pressure. It certainly should be treated, because it may progress and interfere with normal physical and mental development of the child.
The neurologist appointed us two drugs: Sirdalud and Sermion (5 mg).
About Sirdalud I wrote a review here.

It is the turn to share feedback about Sirmion.

During the month, in which he took the medicine, the child began to repeat almost behind us all the words. There has been a rapid speech development. Progress, of course, everyone noticed. Every day a child repeats more and more new words. At the next reception at the neurologist, I have shared with the doctor's son success. The doctor said that this was due to the adoption of stimulant. As I understand it, it was just about Sirmion.
Unfortunately, our main problem - walking on tiptoes son has not disappeared, and we will continue treatment, but other drugs.
Of course, Sermion - is a serious drug.
But I was pleased with the effect resulting from the reception of Sirmione my child.

Nasty, 33 years, Sermion - Improves cerebral and peripheral circulation, is an alpha-blocker

Quick effect really helps

Agree "Sermion" intended neurologist in combination with other drugs after an MRI revealed on several hernias and protrusions in the lumbar spine, and after my complaints about persistent headaches, and pain in the back and legs. The drug is given the result immediately after a couple of days.
"Sermion" - a drug that improves cerebral and peripheral circulation. Also it is an alpha-blocker.
"Sermion" improves hemodynamic and metabolic processes in the brain, reducing platelet aggregation, and improve blood rheology. "Sermion" also increases the rate of blood flow in the upper and lower limbs, has alpha1-adrenoceptor blocking action.

Pain in the back and in the legs disappeared. Ceased headache. I feel much better. Now I can safely walk with a child in the street and even run after him. And before I could not even properly go to the gym because of the terrible pain.
The general condition improved, no longer have to worry and get nervous over nothing.
By appointment of the neurologist I accept "Sermion" 3 times a day for 3 weeks. In combination with other drugs, "Sermion" give an excellent result. After further examination and clarification of diagnosis combined with medication will be prescribed as physiotherapy and massage (which I'm really looking forward to). As I understood neurological diseases quickly and simply can not be cured. I wish everyone good health!