Phezam - Instruction for Use, Analogs, Reviews

Phezam is a combined preparation of nootropics groups that improve cerebral circulation and as a consequence the brain. The drug used in the treatment of cerebrovascular events (eg, atherosclerosis, cerebrovascular disease), stroke, encephalopathy of different origin (eg, on a background of hypertension, traumatic brain injury transferred infections, etc.), dementia (dementia), vascular origin, memory disorders, attention and mental work and labirintopathia, Meniere's syndrome and neurological pathology of childhood.

Composition, names and forms of Phezam release

Phezam currently available in a single dosage form - capsules for oral administration. Often referred to as data capsules tablets, which is not true from the point of view of science, but it is adequate to refer to a dosage form intended for oral administration. However, it should be remembered that when people say "pill Phezam", they mean it is a form for oral administration, that is, the capsule. In addition, there is a widespread misconception drug name "Phezam" which is often used in everyday speech. Therefore hear the term "Phezam", you should know that it is a preparation "Phezam".

The composition of the two active components Phezam preparation includes:

• 1.Cinnarizine - 25 mg;
• 2. Piracetam - 400 mg.

This means that each capsule contains 400 mg Piracetam and 25 mg of cinnarizine. Due to the content of active substances such drug slang for health care workers is often called "Phezam 400 + 25". When a person sees a similar name, do not be afraid, because we are talking about the same Phezam.

As auxiliary components Phezam contains the following ingredients:

• Lactose;
• Colloidal silicon dioxide;
• magnesium stearate.

The capsule shell is 98% gelatin and 2% of titanium dioxide pigment.
Capsules of Phezam are thick, cylindrical shape, painted in white color. Inside the capsule is a powder mixture, painted white or cream color. The powder inside the capsule may have small lumps, which at light pressure dense object (e.g., a spoon, a glass rod, etc.) crumble and turn into powder. Phezam comes in 60 capsule packs.

Phezam - mechanisms of action and the scope of therapeutic applicationThe mechanism of action and therapeutic effects due Phezam active ingredients in its composition. General, the resulting therapeutic and clinical Phezam property is its ability to improve cerebral blood flow and metabolism in the cells and nerve fibers of the brain. In fact, all the other effects it caused Phezam intensification of blood flow and the intensification of metabolism in brain cells.
Since Phezam is a combined preparation, which comprises two active components, we consider the properties of each of them and their resultant of their combined impact.

Piracetam is a nootropic agent which enhances the activity of the brain, providing a positive effect on metabolic processes. Piracetam increases the rate of glucose consumption, which is a major nutrient for the brain because of any other central nervous system cell connections are not able to obtain the necessary life support and functioning of energy. That is, under the influence of piracetam brain cells begin to actively feed on, producing more energy, which is enough to ensure the authority of intensive work. It is this impulse transmission speed between neurons increases, the memory is activated, the attention is concentrated and there is a general improvement of intellectual function.
In addition, piracetam improves blood circulation various brain areas in which there is damage to blood vessels and moderate or weak oxygen deprivation (ischemia). By improving microcirculation in brain ischemia fade zone suffering from deficiency of oxygen and the entire amount of the neurons included in intensive work. Improved blood flow is achieved not only due to direct effects, and indirect, which consists in inhibition of platelet adhesion and, hence, in the prevention of thrombus formation. Thus, not only Piracetam improves blood circulation, and blood properties, making it possible to circulate by suitable Microvessels. In brain areas prone ischemia Piracetam has a protective effect, increasing the resistance of neurons to hypoxia and death.

That is, Piracetam can not only improve cerebral blood circulation, but also to strengthen the integrative brain function (the ability to synthesize and analyze, summarize, non-standard solutions, etc.), to increase the productivity of intellectual work, to consolidate the memory, facilitate the process of learning and mastering new material and maintain and restore functions of the brain in the elderly.

Cinnarizine is a substance having a pronounced influence directly on the brain vessels. So, cinnarizine expands blood vessels of the brain, reducing smooth muscle tone, as well as the severity of their reaction to the biologically active substance constricts blood vessels. Cinnarizine dilates blood vessels, so that blood flow is activated, and the supply of the various parts of the brain with oxygen and nutrients is greatly improved. By improving blood circulation increases the stability of the substance of the brain tissue to the lack of oxygen. However, despite the vasodilating action, Cinnarizine no effect on blood pressure and intracranial.

Piracetam and Cinnarizine together amplify the effects of each other, so the resulting intensity of action Phezam higher compared with preparations isolated using diversity reception by time. However Phezam prevails sedation cinnarizine, so people do not feel agitated as using piracetam.

Phezam - indications for use (from what Phezam tablets)

Currently Phezam is indicated for the treatment of various diseases and conditions associated with cerebral ischemia, injuries and disorders of the integrative function. However, not all state data included in the official list of the indications for use of the drug because their effectiveness has not been proven scientifically. Therefore, we present only a list of the approved, official indications for use Phezam.

Thus, indications for use Phezam is the treatment of the following diseases or conditions:

• Violations of the cerebral circulation of any origin (atherosclerosis of vessels of the brain, stroke, subacute or chronic, the recovery period after a hemorrhagic stroke, traumatic brain injuries, osteochondrosis of the cervical spine, etc.);
• Recovery after suffering a traumatic brain injury;
• Memory impairment; Violation of intellectual function (it is difficult to articulate a thought, it is impossible to find a solution to a simple problem or think about the situation from different points of view, etc.);
• Impaired concentration;
• Mood disorders;
• he intoxication of any origin;
• Asthenia psychogenic origin (anxiety, depression, a sense of emotional discomfort, irritability, lability);
• Encephalopathies of various origins (with chronic hypertension, traumatic brain injury, previous infection, surgery, anesthesia, etc.);
• Dementia (dementia) due to vascular pathology;
• Psychoorganic syndrome with prevalence of fatigue and adinamia triggered by infectious and inflammatory diseases of the nervous system;
• Labirintopatiya (pathology structures of the inner ear), which is manifested by tinnitus, nausea, vomiting, nystagmus, motion sickness;
• Meniere's syndrome;
• Aphasia (speech impairment), provoked by vascular pathology;
• Prevention kinetoses (rocking "motion sickness", etc.);
• Prophylaxis of migraine;
• Easy neurological disorders in children (poor learning ability, poor concentration, lack of long-term memory, etc.);
• The complex method of teaching children who have a backlog of intellectual development.

Phezam (tablets) - Instructions for Use

Phezam Capsules should be taken by mouth, swallowing whole, without chewing, without violating the integrity of the shell, and not emptying the powder into a glass of water. The capsule is necessary to drink a small amount of water (at least half a glass) or any other liquid except carbonated sugary drinks, coffee and caffeine-containing power engineering. For example, capsules can be washed down with Phezam mineral water, juice, tea, fruit drinks, fruit drinks and other beverages. The only condition that must be satisfied for drinking Phezam liquid, - a low temperature, that is, the drink should be hot, but warm or cool.
Phezam capsules can be taken at any time, regardless of the meal. However, if a person is suffering from any disease of the gastrointestinal tract, then it is best to take the capsule Phezam after 20 - 30 minutes after a meal. Moreover, as the food is quite suitable light snack such as an apple, banana or other fruit, a sandwich, a piece of meat, etc.

It should always try to take the capsules in Phezam the same time, such as every day at 9:00 am, or daily at 8-00 and 18-00, depending on how many times a day is recommended drink preparation. And if a man missed an appointment at the scheduled time, you should drink a capsule immediately if not approached the next deadline Phezam. If after a missed deadline capsule came next, you should drink only one, not two, not trying to make up for the forgotten drug.
For the treatment of various diseases adults Phezam should take 1 - 2 capsules three times a day, in one to three months. Children over 5 years of age, but under 18 years of age for the treatment of various diseases and conditions should take Phezam 1 - 2 capsules, but only once or twice a day for 1.5 - 3 months. The duration of therapy is determined by the severity of the disease and the rate of appearance of clinical improvement. It does not take Phezam more than three months without interruption. If necessary, treatment can be repeated 2 - 3 times in one calendar year.

Overdose of Phezam
Overdose of Phezam in a very limited amount of time has been fixed for the entire period of use of the drug. The drug is safe, and even exceeding the therapeutic dosage several times did not cause significant side effects, which would be forced to cancel the person receiving Phezam. The only symptom Phezam overdose in adults can be a pain in the abdomen, which usually normally tolerated and does not require discontinuation of therapy. Overdose Phezam in children manifests insomnia, agitation, irritability, tremors, nightmares, hallucinations or seizures.
In case of any symptoms of overdose in adults and children should be carried out symptomatic treatment aimed at relief of discomfort. In addition, it is recommended to carry out gastric lavage. Phezam Overdose can also be removed by hemodialysis.

Special instructions for Phezam use
Athletes must cancel the drug for 2 - 3 days prior to the test for doping, as contained in Phezam cinnarizine may give positive test.
Furthermore, Phezam use may give a false positive result on the study definition of radioactive iodine as a dye composition capsule contains active microcell. Also Phezam activates the thyroid gland, resulting in a person may appear tremor (shaking) of different parts of the body and anxiety.
If Piracetam is a person insomnia and tension, replace it Phezam that in such situations is the best drug. Also Phezam is the drug of choice, if the doctors at the same time appointed Cinnarizine and Piracetam (this may be the appointment of different doctors).
Against the background of Phezam care should be taken when working with a variety of mechanisms, including while driving, as cinnarizine in the initial stages of therapy can induce drowsiness.
While taking Phezam should refrain from drinking alcohol, as it will trigger a massive destruction of brain cells.
When using Phezam in people with liver disease should be once a week to monitor the activity of transaminases (AST, ALT). An increase in transaminase activity by more than 1.5 times the upper limit of normal should stop taking Phezam.
In the presence of a human kidney disease before prescribing Phezam be determined by creatinine clearance sample Rehberg. If creatinine clearance of 60 ml / min, it can be taken Phezam usual dosage by controlling the laboratory data every 3 - 4 days. If the creatinine clearance was initially less than 60 mL / min or fell against the backdrop of the drug, the dosage should be halved Phezam and increase the intervals between doses.

Pregnancy and lactation
In experiments on animals have revealed the absence of any negative impact Phezam on fetal growth and development. However, in spite of this drug is contraindicated for use during pregnancy. This is due to possible adverse changes in the mental state of women, increase anxiety, emotional lability sphere and mood that is capable of theoretically badly affect the course of pregnancy.
Since Phezam penetrates into milk, the breastfeeding period, he is also contraindicated. If a woman breast feeding a baby, should for any reason to take Phezam, it should be transferred to the baby infant formula.

Interaction with other drugs
Phezam while receiving enhances the effect of sedatives and other nootropics, antihypertensive drugs and alcohol. And Phezam amplifies only a depressing effect on the central nervous system of all these groups of drugs.
Receiving drugs, dilates blood vessels and lowers blood pressure, leads to an increase of Phezam effects. Accordingly, drugs that narrows blood vessels and increase the pressure on the contrary, weaken Phezam effects.
Phezam improves subjective tolerability of drugs from the group of neuroleptics and antidepressants.

Phezam before or after a meal – how to take
In many Phezam instructions for use, which are available on the leaflet does not specify how to take the drug with respect to food intake. Generally, unless specifically indicated as taking medication - before, during or after a meal, which means that it can be used regardless of the food, at any convenient time. This rule holds true for Phezam that really can be taken without regard to food intake at any time convenient for humans.
However, experienced doctors or people who used the drug more than once, it is recommended to take half an hour after eating. Such an option as the best they had been picked up empirically, when we were able to try different reception Phezam - during, before or after meals. The empirical conclusion that it is best to take Phezam half an hour after a meal, based on the fact that it is under this option least likely to develop side effects, and the drug is well tolerated.
If Phezam must be taken several times a day, and full meals for some reason impossible, then you can just bite something, such as an apple, banana, nuts, pastries, sandwiches, etc. instead of lunch, snack or dinner. A small amount of food which has got into the stomach, it will replace a full meal from the standpoint of minimizing the discomfort from the use Phezam. Remember that the phrase "after eating" does not necessarily mean the use of high-grade from your point of view lunch, dinner, breakfast or afternoon snack. It only means that before receiving the drug you need something to eat, for example, a piece of bread, fruit, a sandwich, a piece of jelly or cold meat from the soup, etc.

Phezam for children
Phezam used for therapy in children older than 5 years of age. If necessary, allowed to use Phezam in children from one year.
Phezam in children and adolescents normalizes sleep and eliminates nightmares, relieves nocturnal awakenings, reduces fatigue, increases efficiency, both mental and physical, as well as relieves irritability, emotional instability, mood lability, and excessive vulnerability. In addition, Phezam reduce the frequency of headaches in children, improve adaptation to school or pre-school team, stabilizes and maintains normal blood pressure, profilaktiruya his jumps. In general Phezam normalizes neuro-psychological status of children, particularly suffering from various disorders of emotional and volitional.
Currently, as a rule, Phezam used to eliminate poor sleep, irritability, tearfulness, mood instability, hysteria, poor concentration, and other lung disorders, emotional and volitional and early school age children. The drug is usually appoints a neurologist, not a psychiatrist, because it is not suited for treatment of severe mental illnesses, and to eliminate lung disorders can be successfully used.
After the course, the use of child becomes balanced, less whiny, focused, attentive, he is not as quick and easy to upset his mood does not change within one minute several times, it is much quieter sleeping at night, and the mastery of speech and other skills takes place successfully and quickly . Such positive changes, coupled with a good tolerability allow doctors and parents believe Phezam effective drug and use it to improve mental performance and development of children.
In addition, Phezam successfully used in children for the treatment of perinatal lesions of the central nervous system, recovery after traumatic brain injury and infectious diseases. In such situations, the drug normalizes the brain, reduces headaches, stabilizes night's sleep, but also improves the adaptation to the team and the ability to learn. Also Phezam can improve the situation and promote the recovery of children with autism and neurological disorders suffer mild degree.

Phezam - side effects
Phezam in most cases well tolerated and rarely causes side effects. According to international standards, all side effects are classified into several groups depending on their frequency of occurrence. Regarding Phezam it was found that all side effects are recorded either sometimes or rarely. Moreover, "sometimes", according to international classification, it means that the effect is developing at least one person in a hundred, but more than 1 out of 1000 A "rare" means that a side effect is higher than that of 1 10 000 but less than 1 in 1000. All Phezam side effects are transient, ie, disappear on their own after the abolition of the drug and do not require any special treatment.

Side effects Phezam include the following symptoms of the various organs and systems:

• 1.From the side of the central nervous system: hyperkinesia (twitching of the limbs, excessive movement, etc.); Nervousness; Drowsiness; Depression; Dizziness; Headache; Ataxia (incoordination); Imbalance; Insomnia; Confusion; Excitation; Anxiety; Hallucinations.
• 2.From the gastrointestinal tract: Excessive salivation; Nausea; Vomiting; Diarrhea; Abdominal pain; Dry mouth.
• 3. Allergic reactions: rash on the skin; Dermatitis; Itching of the skin; Edema; Photosensitivity.
• 4.Other: Disinhibition sexual behavior; Increased sexual desire; Weight gain; limb tremor; Increased muscle tone.

Contraindications for Phezam
There are relative and absolute contraindications to the use Phezam. Absolute are conditions under which the drug can not be used, under any circumstances. A relative contraindication for which the product can be used in compliance with caution and under medical supervision.
Absolute contraindications to the use Phezam are the following diseases and conditions: Heavy renal failure in which serum creatinine clearance of less than 20 ml / min; Severe hepatic impairment; Psychomotor agitation, available at the time the funds; Huntington's Chorea; Acute hemorrhagic stroke; Pregnancy; Breast-feeding; Age younger than 5 years; The sensitivity or idiosyncrasy of the drug components.
Relative contraindications to the use of Phezam are the following conditions or diseases: Parkinson's; Bleeding disorders; Severe bleeding; Diseases or conditions in which elevated intraocular pressure.

Phezam - analogues
Currently in the pharmaceutical markets of Russia and the former Soviet Union there are analogues and synonyms Phezam. Synonyms are called drugs, containing exactly the same active ingredients as Phezam. The analogs find formulations containing different active substances (not the same as in Phezam) but having similar pharmacological and therapeutic effects.

Today on sale has the following drugs-synonyms Phezam:

Combitropil capsule; Nooñàm the capsule; Omaron tablets; Ðiracezine capsule.

Phezam analogs are the following medications:
1. Lucidril (Acephen) tablets; 2. Bravinton concentrate; 3. Vero Vinpocetine tablets; 4. Vinpotropile capsules and solution; 5. Vinpocetine tablets and concentrate; 6. Vinpocetine forte tablets; 7. Vincetine tablets; 8. Glycine and Glycine Forte tablets; 9. Gopantam tablets; 10. Demanol solution; 11. Idebenone capsules and tablets; 12. Cavintonum tablets and concentrate; 13. Cavintonum forte; 14. Gopantenat Calcium tablets; 15. Carnicetine capsule; 16. Cogitum solution; 17. Combitropil capsule; 18. Corsavin and Corsavin forte tablets; 19. Cortexin lyophilisate and dry extract; 20. Lucet tablets and solution; 21. Memotropil tablets; 22. Minis drops; 23. Neirometcapsule; 24. Noben capsule; 25. Noocam capsules; 26. Nooclerin solution; 27. Noopept tablets; 28. Nootropil capsules, tablets and solution; 29. Omaron tablets; 30. Pantogam syrup and tablets; 31. Pantokalcin tablets; 32. Picamilon tablets and solution; 33. Piracezine capsule; 34. Piracetam granules, capsules and the solution; 35. Pyritinol tablets; 36. Telcktol tablets; 37. Tiocetam tablets and solution; 38. Fenotropil tablets; 39. Celestab capsule; 40. Ñellex solution; 41. Ceraxon solution; 42. Cerebrolysin solution; 43. Cerebrolysin solution; 44. Encephabol tablets and suspension; 45. Epytalaminum powder; 46. Escotropil solution.

Phezam (tablets) - reviews
Reviews Phezam differ, among them about 60% positive and 40% negative. Positive feedback due to the visible clinical improvement of the human condition, normalization of memory, attention and increase mental performance were observed after administration of the course. Also positive feedback about Phezam related to its ability to reduce stress and anxiety during any stressful moments in life, such as exams, interviews for a good job, etc. Also, people in a positive effect Phezam note his ability to stop dizziness and headaches caused by vascular disease. In such cases, people do not take Phezam rate, and batch as needed as a means, such as a headache.
Some people Phezam is irresistible sleepiness, which makes taking the drug only in the evening or after work. But who is willing to tolerate the drug minus the generally good considering it because of other positive effects, and leaving a positive feedback accordingly. And other people can not tolerate such a property of the drug, thus forced to abandon his reception, and because of Phezam leave negative feedback.
In addition, the negative reviews about Phezam due to lack of the desired effect and the unpleasant side effects that forced to stop taking the drug. Also negative comments people leave in the development of low-energy improvements, which essentially does not alter the overall human condition.

Reviews of doctors
Doctors about Phezam usually positive, due to the efficacy of the drug in many people, as well as the fact that it can replace several medications. In addition, the positive opinion of doctors due to rare side effects arising from the application Phezam that allows to be sure of the patient's condition and not select the dosage for a long time. Also important advantage of the drug is its low cost, by which it can acquire virtually all patients.
Negative reviews about the doctors Phezam caused, as a rule, not clinical observations and experience, and the lack of scientific evidence of its effectiveness. Based on the fact that the clinical effects of the drug are not scientifically proven, some physicians believe a priori Phezam not medicine, and "empty shell", and leave it on the extremely negative reviews.
However, this categorization does not always reflect the truth, because even a drug with unproven efficacy can have a pronounced therapeutic effect in many people subjectively improve their condition. But even such an effect can not be called useless, because the well-being and quality of life is improved, respectively, too. Of course Phezam can not cure serious diseases, but the lungs disorder and painful symptoms can help eliminate.

What better than Phezam?
In medical science and practice, not the term "best" is used because each person is different, and all the possible effects of the interaction of the organism with a chemical compound can not be predicted, and therefore distinguish the drug, which is equally good for all is simply impossible. Doctors and scientists instead of the term "best" use of the term "best", the meaning of which is that this drug in this particular situation is the best for the person. All this is true of Phezam.
Therefore, if a person is not suitable Phezam, or he wants to get the best effect, you should look for another drug with similar properties among peers. And one that will satisfy everyone's wishes, and will be "better than Phezam".

Phezam - price
Since Phezam produced by domestic Russian pharmaceutical factories, its cost is relatively low. A difference in the value of retail sales are due to the selling price, the cost of transportation and storage, as well as the trade margin particular pharmacy network. In principle, the same drug manufacturing technology and is used in all pharmaceutical enterprises, so the difference between the more expensive and the cheapest drug there is none.

Where to buy Phezam?
Currently Phezam officially sold by prescription, so you can buy the drug only in a conventional pharmacy. However, pharmacists often sell the drug without a prescription, or only on the basis of an entry in the medical human map. But such luck can not be permanent, so if you need to buy Phezam better to consult a doctor for a prescription.
When you purchase should pay attention to the shelf life of the drug, which is 3 years from date of manufacture. Phezam be stored in a dark place at a temperature not above 25 ° C. Violation of the storage conditions lead to loss of active properties that weakens Phezam therapeutic effect.