Pantogam-active pills - Instructions for Use, Dosage, Side Effects, Reviews

Active substance: D,L-hopantenic acid.

ATC - N06BX Other psychostimulants and nootropics.

Pharmacological group – Nootropics.

Hopantenic acid (homopantothenic acid), also known as N-pantoyl-GABA, is a central nervous system depressant. Formulated as the calcium salt, it is used as a pharmaceutical drug in the Russian Federation for a variety of neurological, psychological and psychiatric conditions and sold as Pantogam.

Nosological classification (ICD–10)

E63 Physical and mental overload;

E83.0 Disorders of copper;

F06.7 Mild cognitive disorder;

F20 Schizophrenia;

F48.9 Neurotic disorder, unspecified;

F79 Mental retardation, unspecified;

F80 Specific developmental disorders of speech and language;

F81 Specific developmental disorders of learning skills;

F82 Specific developmental disorders of motor function;

F84.4 Overactive disorder associated with mental retardation and stereotyped movements;

F90.0 disturbance of activity and attention;

F95 Tiks;

F95.9 Tiks unspecified;

F98.0 Enuresis inorganic nature;

F98.5 Stuttering [ hesitation ];

G10 Huntington’s disease;

G20 Parkinson’s Disease;

G25 Other extrapyramidal and movement disorders;

G25.3 Myoclonus;

G40 Epilepsy;

G40.8 Other specified forms of epilepsy;

G40.9 Epilepsy, unspecified;

G80 Cerebral Palsy;

I67.2 Cerebral atherosclerosis;

I67.9 Cerebrovascular disease, unspecified;

N31.2 Neurogenic bladder weakness, not elsewhere classified;

P91.9 Violation by the brain of the newborn, unspecified;

R25.8.0 * hyperkinesia;

R32 Incontinence unspecified;

R35 polyuria;

R41.3.0 * Reduced memory;

R41.8.0 * Disorders Intellectual mnestic;

R46.3 Excessive of activity;

R62 Lack of expected normal physiological development;

S06 intracranial injury;

T43.3 Poisoning and antipsychotic neuroleptic drugs;

T90.5 Effects of intracranial injury;

Y49.5 Adverse reactions in the therapeutic use of other antipsychotics and neuroleptics.

Pantogam-active Composition, structure and packing

Hard gelatin capsules, yellow contents of capsules - powder white or white with a yellowish tint.

Excipients: microcrystalline cellulose, magnesium stearate.

The composition of the capsule shell: gelatin, glycerol (glycerine), nipagin (Valium), nipazol (Propyl), sodium lauryl sulphate, purified water, titanium dioxide, iron oxide yellow.

Pantogam-active Pharmacological action

Step Pantogam activity due to the presence in its structure of gamma-aminobutyric acid, which acts directly on the GABA B receptor-channel complex. Pantogamum asset is a racemic mixture of equal amounts of R-form hopantenic acid and its S-isomer. Isomer presence improves transport and drug interaction with GABA receptor. Pantogamum asset has a more pronounced neuroprotective and anticonvulsant effects than drugs hopantenic acid first generation.

Pantogamum asset increases resistance to cerebral hypoxia and exposure to toxic substances, stimulates anabolic processes in neurons combines moderate sedation with a mild stimulant effect. Has anti-asthenic and easy anti-disturbing action. Reduces the excitability of the motor, regulates behavior. Activates brain activity and performance. Causes inhibition of pathologically increased vesical reflex and detrusor tone.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract. Penetrates the blood-brain barrier. Is not metabolized and is excreted unchanged within 48 hours: about 70% of the dose - in the urine, about 30% - in the feces.

Pantogam-active Dosage

Inside, after 15–20 minutes after meals, 2–3 times/day, preferably in the morning and afternoon.

Capsules of 200 mg - 4.1 capsules (0.2–0.8 g). The maximum daily dose - 12 capsules (2.4 g).

300 mg capsules - 1–3 capsules (0.3–0.9 g). The maximum daily dose is 8 capsules (2.4 g). The course of treatment - 1–4 months, sometimes up to 6–12 months. 3–6 months is possible the re-treatment. Pantogam-active Overdose

Intensification of symptoms of side effects.

Treatment: activated charcoal, gastric lavage, symptomatic therapy.

Pantogam-active Drug Interactions

Prolongs the effect of barbiturates, enhances the effects of anticonvulsants to prevent side effects of phenobarbital, carbamazepine, neuroleptics.

Effect Pantogam enhanced activity when combined with glycine, etidronic acid.

Potentiates the action of local anesthetics (procaine).

Pantogam-active at Pregnancy and lactation

The drug is contraindicated in pregnancy (I trimester) and lactation.

Pantogam-active Side effects

In rare cases, allergic reactions (rhinitis, conjunctivitis, skin rashes). In this case, reduce the dose or cancel drug. Sleep disturbances or drowsiness, noise in my head - these symptoms are usually short-lived and do not require discontinuation of therapy.

Pantogam-active Indications

Cognitive impairment in patients with organic brain lesions (including effects neuroinfections and traumatic brain injury) and neurotic disorders;

Cerebrovascular insufficiency caused by atherosclerotic changes of cerebral vessels;

Extrapyramidal hyperkinesis (myoclonus epilepsy, Huntington’s chorea, hepatolenticular degeneration, Parkinson’s disease and others), as well as for the treatment of extrapyramidal syndrome induced by classical neuroleptics;

Epilepsy together with anticonvulsants;

Psycho-emotional overload, reduced mental and physical performance, to improve concentration and memory;

Neurogenic bladder disorders (pollakiuria, urgency, imperative urinary incontinence, enuresis);

Schizophrenia in adjuvant therapy.

Pantogam-active Contraindications

Acute severe kidney disease;

Pregnancy (I term);

Lactation;

Patient age of 18 years (there are no clinical studies on the use of the drug in this age group);

Hypersensitivity.

Pantogam-active Cautions

In the context of long-term treatment is not recommended to co-administration of the drug with other CNS stimulant and nootropic agents.

Pantogam-active Reviews

Jane, 36 years, "Pantogam-active" - Superior Pantogam.Now I'm cutting the ordinary course Pantogam, too, from Crest Farm.
Prior to that, in the hospital gave me Pantogam Plus. It is better to have what is contained in the capsules. It is easier and more enjoyable to take.

How much better it is usual drug - a judge pharmacists and doctors. I just do not have time to sit and calculate and deduct the entire benefit of the drug.
The fact is, what it is to take the drug. What was he going in the complex. From this and it depends on its efficacy. So I told the doctor and I quite liked the answer from. As I felt myself improving concentration and memory performance (both physical and mental), increased at times.

Vladislava, 33 years, Pantogam Active - accelerates brain.Hello! In this review I will tell you about nootropics Pantogam assets.Packing 300 mg. The package of 60 capsules. I took the drug three times a day for one tablet. The effect does not come as quickly as we would like: after 3 weeks of treatment. The effect was expressed in enhancing efficiency, improve thinking and memory, increased concentration. I began to pour and easy to wake up in the morning, the whole day was in the waking state, the head throughout the day was fresh, thinking speed increased. Anxiolytic effect Pantogam I, unfortunately, did not find. Action Pantogam Asset amplified at reception for 15 minutes before the glycine sublingually. Manifestations of adverse effects on myself, I have not noticed. Soon I am going to drink again. Unlike Pantogam, which is suitable for children, Active Pantogam are more suitable for adults. Course admission preaparata is 1-4 months, then 3-6 months can repeat dosing. In preparation like the fact that there is practically no contraindications and side effects are not as pronounced and generally not occur. It should also be noted that the drug should be used in the morning and afternoon hours. This is one of the few neuroprotective agents, which gave me almost everything, except for the long term existence of the effect.