The packaging NEXT read the phrase "combined analgesic", what does it mean?
The composition of the two active substances NEXT analgesic included (component) has a pronounced analgesic effect, but differ in their mechanism of action. Paracetamol has a central analgesic action, while Ibuprofen - predominantly peripheral analgesic and anti-inflammatory effect. Combination analgesics with two different modes of action provides a different effect on the pathogenesis (blocks formation), pain, in order to achieve greater efficiency and thus improve the safety profile (by reducing the dose of paracetamol, compared to monotherapy).
At the pharmacy I was offered instead of the ibuprofen analgesic NEXT try, what's the difference between them?
Ibuprofen is a nonsteroidal anti-inflammatory drugs (NSAID) has analgesic and anti-inflammatory effect mainly in peripheral tissues - by blocking the enzymes cyclooxygenase 1 and 2. NEXT is a combination of ibuprofen and paracetamol. Paracetamol has an impact on the formation of a central component of pain, ie. K. Does not act in the peripheral tissues and the central nervous system. The combination of two analgesics with different mechanism of action allows for rapid and pronounced clinical effect.
Can NEXT drug addictive?
The results of these studies the efficacy and safety of the drug component - paracetamol and ibuprofen - indicate a lack of tolerance and dependence in their application, even in the case of long-term use. In addition, please note that, according to the medical application instruction, the maximum duration of the reception NEXT preparation is no more than 3 days as antipyretic and not more than 5 days - as an analgesic. Longer treatment is possible only after consultation with your doctor.
The instructions to the drug NEXT in the testimony given to the use of "headache (including migraine)." And what is the difference?
Headache can be due to various reasons, there are currently more than 100 types of headaches. Headache may be the leading symptom in more than 45 different diseases. This migraine is a self-diagnosis, due to the nature of its development mechanisms (in particular, the participation of neurogenic and vascular factors) and the serious impact on the overall well-being and even the quality of life of patients. Treatment of migraine headaches require an integrated approach, with the preparations of paracetamol and NSAIDs, are usually the first step in migraine therapy.
Can I use the NEXT during pregnancy?
Studies on the effect of NEXT on the drug during pregnancy has not been. The use of paracetamol during pregnancy is permitted with care by a physician. Ibuprofen is contraindicated in the III trimester of pregnancy, and can be used with caution in I and II trimester of pregnancy. Therefore, use of the drug is contraindicated during NEXT III trimester of pregnancy; if necessary, use of the drug in the I and II trimester of pregnancy should be careful - the application can only be prescribed by a doctor in cases where the potential benefits outweigh the possible risk.