Oxazepam - Interactions with other Active Compounds

Oxazepam + Abacavir + Lamivudine + Zidovudine

Metabolism zidovudine (consisting of a combination of abacavir + lamivudine + zidovudine) is carried out mainly in the liver, involving the conjugation reactions, leads to the formation of inactive glucuronide. Oxazepam the combined use can influence the metabolism of zidovudine (consisting of a combination of abacavir + lamivudine + zidovudine) by competitive binding with glucuronic acid or a direct inhibitory effect on liver microsomal enzymes. Before you assign oxazepam in conjunction with the combination of abacavir + lamivudine + zidovudine, you must carefully weigh the possibility of interaction - especially if you plan long-term treatment.

Oxazepam + Alprazolam

(Mutually) oppression CNS.

Oxazepam + Benzathine benzylpenicillin

With greater ability to bind to plasma proteins, increases the content of the free fraction in plasma (replacing with fixation locations).

Oxazepam + Buprenorphine

(Mutually) oppression CNS.

Oxazepam + Valproic acid

Against the background of valproic acid is enhanced CNS depression.

Oxazepam + Haloperidol

Oxazepam (mutually) oppression CNS. You can buy Haloperidol.

Oxazepam + hydroxyzine

Oxazepam (mutually) effects; the combined use of dose should be reduced by 50% - a high probability of severe, even fatal, complications.

Oxazepam + glipizide

Oxazepam displaces from its association with proteins, increases the content of the free-form the blood and increases the effect. The combined application may require dose adjustment.

Oxazepam + guanfacine

(Mutually) sedation.

Oxazepam + Diazepam

It increases the effect. Against the background of / in the introduction of diazepam increases CNS depression and an increased risk of apnea.

Oxazepam + diphenhydramine

(Mutually) oppression CNS, may increase the hypnotic effect.

Oxazepam + Zidovudine + lamivudine + nevirapine

Oxazepam during concomitant use with zidovudine (consisting of a combination of lamivudine + zidovudine + nevirapine) modifies the intensity of the biotransformation of zidovudine, which in turn increases the likelihood and frequency of adverse events.

Oxazepam + Zidovudine + lamivudine

Zidovudine (consisting of a combination of zidovudine + lamivudine) is eliminated predominantly by hepatic metabolism to an inactive glucuronide. Oxazepam may alter the metabolism of zidovudine (consisting of a combination of zidovudine + lamivudine) as a result of competitive inhibition of glucuronidation process or direct repression of microsomal metabolism of zidovudine. Before the appointment of oxazepam in conjunction with the combination of zidovudine + lamivudine, especially for long-term treatment, it is necessary to evaluate the possible interaction.

Oxazepam + Clonazepam

The potentiation of CNS depression.

Oxazepam + Caffeine

If concomitant use of high doses of caffeine weaken the effects of oxazepam.

Oxazepam + Metoclopramide

(Mutually) sedation.

Oxazepam + Omeprazole

Against the background of omeprazole (inhibits CYP450 system) slows the biotransformation and prolonged effect oxazepam.

Oxazepam + piroxicam

Against the background of increasing the free fraction of piroxicam concentration in plasma (displaced from its association with proteins) may increase a therapeutic effect and risk of collateral.

Oxazepam + promethazine

Oxazepam enhances and prolongs the (mutually) sedation; with a joint appointment must be to reduce the dose.

Oxazepam + Propofol

(Mutually) effects; combined with the appointment of possible distinct reduction in systolic, diastolic, and mean arterial pressure and cardiac output.

Oxazepam + Risperidone

When used together, care is needed.

Oxazepam + Topiramate

(Mutually) oppression CNS.

Oxazepam + Tramadol

(Mutually) effect; concomitant use increases the risk of seizures.

Oxazepam + fluvoxamine

Fluvoxamine does not affect the excretion of oxazepam.

Oxazepam + cyproheptadine

The combined application of cyproheptadine and oxazepam deprimation mutually amplified and reduced speed of psychomotor reactions.