Neuroleptics, Antipsychotics. Part 8

It remains to close the topic of neuroleptics, told about the special form of their release - on prolonged. That is so, when once pricked - and a few weeks free. In the sense that the pill can not drink: the drug is slowly released from the depot created and do your job. Particularly useful such a form of release for the treatment of those patients who forget to take pills on schedule, or deliberately fed their large white toilet. The main purpose of Prolong - supportive treatment, when the patient has already been discharged from hospital, but since the risk of re-sharpening in the future is still here, I would not want to, he found himself there again.

But first, a couple of words about one more preparation, I did not have time to mention when talking about atypical antipsychotics.

It is Paliperidone. Or Invega, if we take its trade name (generic is not released). According to the chemical formula is very similar to Risperidone. Just from Risperidone bitten off one hydroxyl tail - and here's a new drug. Very similar to its prototype in regard to the action on the paranoid symptoms, but on the one hand, the breaking of its more active, and on the other hand - more gentle to the organism as a whole. That is, neuroleptic syndrome it causes a little less frequently drowsiness and dizziness - a little less, and a soothing, sedative effect it has somewhat stronger than that of Risperidone. However, weight gain and increased prolactin levels in the blood with all the consequences it causes as well as risperidone, but there's nothing to be done. Plus another advantage: in order to process this drug, do not need to actively participate in the process of the liver (it has already been partially processed at the production stage), so Paliperidone can be assigned to those who have a problem with that. Or, with less fear prescribe it along with those drugs, which, for its processing of the active participation of the liver require. And by the way, in addition to the usual forms of release (ie, tablets), a drug produced in the form Paliperidone palmitate (or Xeplion), which make intramuscularly once a month.

And now the other Prolong.

Haloperidol decanoate. As the name implies, is an analogue of haloperidol - or rather, a derivative thereof. And apply, respectively, in those cases in which it would be assigned to haloperidol tablets or drops. Just an average of once a month. Or once every three weeks. Or every other: it depends on what the average dose of medication necessary to keep blood. The fact is that everything here is quite individual: someone, and once a month is enough, and someone once a week and gives only a more or less acceptable effect. You can buy online Haloperidol.

Fluphenazine depot. He DITT depot. Another analogue - liorodin depot - have not seen in pharmacies. By the principle of action - similar to trifluoperazine. That is, it operates mainly in the delirium, and only secondarily on hallucinations. It is used in the same way as haloperidol decanoate - or once a month, often more, individually and as.

From prolonged forms of zuclopenthixol (with the same basic effect and the points of application), there are two:

CLOPIXOL-ACUPHASE. Injections are done every 2-3 days. Often? Well, yes, quite often. But the goal they have is different than that prolong not supported, and the main treatment for the coming aggravation. That is, when it is necessary to quickly achieve the desired drug concentration in the blood to relieve the aggravation. Once the goal is reached - you can proceed to the appointment of a second drug (of course, provided that the zuclopenthixol this particular patient is suitable).

Clopixol Depot. Just as zuclopenthixol, acts mainly on hallucinatory, and only secondarily to a lesser extent - on delusional symptoms. Injections once a month on average. Sometimes (as in the case of haloperidol decanoate and DITT depot) - more often if needed.

Fluanxol Depot.At the point of application is similar to flupentixol, that is increasingly acting on delusions. Done once a month. Or more often if necessary.

From the new, atypical antipsychotics in retarded form is in the course of two: palperidona palmitate (aka Xeplion, about which I wrote here) and rispolept Consta.

Rispolept Consta. Base - risperidone. With the same spectrum and indications for the use and therefore with the same set of side effects. Unlike those Prolong, which have already been discussed, injection rispolepta made Consta every two weeks. Less imeeet not make sense, because it would not be maintained the desired concentration of the drug in the body.

From Prolong I deliberately did not mention piportil L4, because it have not imported in the Russian pharmacy. In the next post will be to tell you about tranquilizers, antidepressants, mood stabilizers, proofreaders neuroleptic syndrome and other magic potions from a psychiatric suitcase.