Nature of Stem Cells

Driving the existence of individual stem cells that can regenerate the whole tissue is already well established. The fabric has a single stem cells, very few of them, they are very rarely shared. Part of their descendants have the ability to retain the possibility to remain a stem cell, part goes descendants differentiation, they begin to actively share (stem cell divides inactive), then differentiate, and working as a rule, in most cases, if the populations are quickly updated, then die. This scheme has grown from experiments Till and McCulloch, and now it is more or less confirmed for those tissues where there is an update. If the fabric is not updated, there is no or stem cells or their role in recovery is extremely small. In addition to the stem cells of the adult body tissues such organization is inherent in the scheme and tumor tissues.

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When we take embryonic stem cells and make them conditional neuronal precursors, and then try to put them in person, in the worst case, they will die, but they can not make the tumor. Maintain or IPS-embryonic cells in the state in which they are, so that they can of itself something to produce and thus replicate - it is very difficult and requires many complex conditions that cause them to remain in that unstable state. If, during the differentiation of them something goes wrong, they either die or turn into something else, is not it, what we are trying to convert them.