Nano-packaging for Semax

In order to protect peptides from destruction and help them to overcome the blood-brain barrier, the Moscow scientists offer to enter into a drug into liposomes.

Neuropeptide semax is wonderful stimulant mental performance. To increase the stability of the drug and deliver it to the brain cells to allow liposomes - nanospheres of lipids.

Neuropeptide - proteins that affect the central nervous system, for many years attracting the attention of researchers. Semax, for example, not only has beneficial effects on the digestibility and memory information, but also promotes recovery after cerebral stroke. However, neuropeptides have a few drawbacks. In the body, they are destroyed rapidly, and almost no blood comes from the brain and are therefore difficult to use as drugs. In order to protect peptides from destruction and help them to overcome the blood-brain barrier, the Moscow scientists offer to enter into a drug into liposomes. Consisting of lipids, they fuse with cell membranes, so that the contents can penetrate the blood-brain barrier.

Researchers concluded semaks liposome derived from soy or a mixture of distearoyl lipid. In the presence of various enzymes that break down the protein isolated from the blood and brain of rats Semax embedded in liposomes destroyed much smaller than outside them. Liposomes can save up to 90 percent of the enzyme. Preservation of the protein depends on the biological environment in which the liposomes are, and on the nature of the liposomes themselves. Scientists hope that the use of the latter will allow for the delivery of neuropeptides to the cells of the central and peripheral nervous system.