Methylcobalamin

Pharmacological group: vitamer; vitamer vitamin B; vitamin B12 vitamer

Pharmacological action: coenzyme form of vitamin B12. Participates in transmethylation processes in the synthesis of proteins and nucleic acids in the metabolism of carbohydrates and lipids. It has anabolic effect (increasing physical performance), regenerating effect in mechanical and toxic damage of the nerve trunks. In diseases of the peripheral nervous system reduces pain, promotes restoration of motor function and reduce autonomic disorders. Providing hepatoprotective effect, a positive effect on liver function in toxic hepatitis, liver cirrhosis, pancreatitis. Reduces damage joints with adjuvant arthritis, has hematopoietic effect.
Usage: oral, sublingual, injection
Formula: C63H91CoN13O14P
Mol. weight: 1344.40 g / mol

Methylcobalamin (mekobalamin, MeCbl or MeB12) - is cobalamin form of vitamin B12. The material differs from cyanocobalamin in that the cyanide is replaced by a methyl group. Methylcobalamin has octahedral center cobalt (III). Externally, the substance is a bright red crystals. From the viewpoint of coordination chemistry, methylcobalamin is notable as a rare example of a compound containing metal-alkyl. Intermediates methyl-nickel have been proposed for the final step of methanogenesis. Methylcobalamin physiologically equivalent vitamin B12, and can be used for preventing or treating pathologies occurring due to the lack of vitamin B12, for example, pernicious anemia. Methylcobalamin is also used for the treatment of peripheral neuropathy, diabetic neuropathy, and as a pre-treatment of amyotrophic lateral sclerosis.

Production of methylcobalamin
Methylcobalamin physically resembles the other forms of vitamin B12, and appears as dark red crystals, readily soluble in water forming transparent solutions and cherry. Methylcobalamin can be obtained in laboratory conditions associated with reduction of cyanocobalamin sodium borohydride in alkaline solution followed by addition of methyl iodide. You can buy - Vitamin B12 cyanocobalamin injection.

Features Methylcobalamin
Vitamer It is one of two active coenzyme, the enzyme used, dependent on the vitamin B12 and the specific form of vitamin B12 used 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase. Methylcobalamin involved in the reaction Wood-Ljungdahl, by which some organisms use carbon dioxide as a source of organic compounds. In this reaction, methylcobalamin donates a methyl group that is bound to a carbon monoxide (prepared from CO2), producing acetyl-CoA. Acetyl-CoA is derived from acetic acid, which is converted to more complex molecules within the body. Methylcobalamin produce some bacteria. It plays an important role in environments where it is responsible for some heavy metals biometilyatsiyu. For example, the highly toxic methylmercury is produced by the action of methylcobalamin. Here methylcobalamin serves as a source «CH3 +».

Availability:
Methylcobalamin is taken for treatment of diseases of the peripheral nervous system, chronic hepatitis, fatty liver, cirrhosis, chronic pancreatitis, and, where necessary, improve physical performance (including sports). The drug is available without prescription.