Limitless NZT-48 Pill

This issue bears a familiarization character with the most promising compounds, modifications which, in the future, may become something of a legendary pills to improve intelligence - NZT-48. For reference, the author of the book "Limitless" taking as a basis for tablet NZT - Modafinil.

This material carries significant meaning, and it may be necessary to listen to it more than once to understand the concept of one of the most powerful cognitive enhancers. Here we parse compounds that are directly related to cellular mechanisms of memory formation. Research on humans is extremely small, so it will be further described mechanism of action. Data on doses to people in the context of strengthening the intellectual abilities virtually none. Some of the compounds are hazardous to health.

Part 1 of the information is taken from the book «Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors». As of autumn 2016, in English only. In the same book there are references to the study.
Part 2 introduces the histone deacetylase inhibitors - substances that work directly with the DNA.

Part 1. Cognitive Enhancement.

• 1.DCP-LA (a derivative of linoleic acid) prevents memory loss in rats, the substance stimulates synaptogenesis and inhibits apoptosis - the extinction of nerve cells. This is when our nerve cells like a "pumped", increase in size expense of the formation of large connections with other cells. Presumably the increase in the number of acetylcholine receptors. Roughly speaking, this thing is great for memory, especially when we try to remember. The substance will accelerate this process. In studies in rats were used dosage from 0.25 to 1 mg per 1 kg.
• 2.Bryostatin - anticancer drug. Has effect on protein kinase C in the short term, he activates it, in the long - inhibits. Protein kinases regulate the cell cycle, cell growth and differentiation, they are processed like proteins derived from food. A known protein - building material. Now the substance passes preclinical trials in the US for Alzheimer's disease. In studies on rats has cognitive and antidepressant effects. While this substance is very rare and expensive (about $ 400 for 1-2 mg).
• 3.7,8-Dihydroxyflavone (7,8-DHF) - TrkB receptor agonist. This is a receptor on the surface of the nerve cell, which works BDNF, NT3 and NT4, ie a substance very similar to BDNF. Thus, the substance enhances cognitive ability.

Part 2: Histone Deacetylase Inhibitors

The theme, announced some time ago, and you're pretty positive about it spoke. So, what is this terrible phrase?
We go from the simple to the complex. The human body is composed of various tissues. Fabrics are composed of cells. The cells have a nucleus, a chromosome in nuclei, chromosomes - DNA. Such is the nesting doll. DNA has the genetic information, the base of the body of data. Hair color and eye - a prime example of the DNA work. With DNA information is read by RNA and ribosomal RNA are working on the basis that just build different connections: hair, bone, and muscle.

With the DNA more or less clear. Histones - proteins consisting of several amino acids, something like glue to the DNA strands. Deacetylase means the removal of the acetyl group. Merge: histone deacetylase - a chemical reaction that causes the removal of the acetyl group. This allows tight binding of DNA to the histones. All! Histone deacetylase - an adhesive for DNA!

We need to understand that kind of thing: More dense packing of DNA reduces the availability to extract RNA information. Our adhesive in the form of histones are so powerful that hardly DNA provides information about anything. It is logical to ask a tricky question: what for actually happens? To monitor and control parameters such as cell growth and death, as an example, cancers.

Actions of histone deacetylases reduce gene expression, make it difficult to read the information from the DNA to build protein structures. This is normal. With hypo-acetylation, when "many histone deacetylases," as if the cell is fixed and there is a reduced DNA methylation. And this is a risk for the occurrence of cancer.

Confused?) Try really easy!
DNA methylation - is something like a small upgrade of DNA without altering its structure. Methylation conventionally enough - DNA is not updated and there is copying data as if from the old version. And if it has a small error? Errors are copied like any Agent Smith in the Matrix and in the end - of cancers. Everything is explained on the fingers, so that the DNA experts, please calm down!
We turn to the most interesting - that if you enter a histone deacetylase inhibitor? To allow the DNA easier to copy information for methylation. That's right - will be easier to be the expression of genes or the construction of protein compounds. Simply update DNA recovery even cancer cells. And it is a huge field of research.

And again: histone deacetylase linked, bonded DNA complicate copying information. Inhibitors of histone deacetylases - unleash the DNA, the DNA is easier to update and transfer of information.

Our project aims to study the brain and intelligence. What if I told you that you will be able to more quickly build synaptic connections between neurons, and maybe even themselves neurons at the same level of learning anything? What if they become so strong that you are deaf and old age will remember everything. I read something a few times and remembered for years.

The main inhibitors of histone deacetylases (HDACi)

There are 11 types of HDAC, these types have similarities, yet sometimes differ by location and function.

It should be noted that these inhibitors improve the long-term memory.

There is a direct dependence of the activity of these inhibitors to factor BDNF, which is crucial to a good memory. In many early issues we mentioned BDNF and now found its connection with the processes going on at the DNA level.

Taken together, research is most clearly Memory important inhibitors of histone deacetylase 2, 3 and 4 - type.

As for the type 1, ie research on the regulation of fear and stressful memories. Ie, to make it easier to forget the negative undesirable drink inhibitors of type 1. But we can not yet say that they are only responsible for fear, and ordinary memories are not remembered.

Memory loss in the elderly is associated, including a histone deacetylase type 4.

Therefore, substances that are to some extent inhibit histone deacetylase:
- Valproic acid. Old drug, increases the content of GABA in the brain. Histone deacetylase inhibitor of all types. A study conducted on chickens, the author - Konstantin Anokhin. Chickens tossed inedible burning bead soaked in a special solution, similar to the food they were eating it and understand that it is not food, and acking one. After 24 hours, most of the chickens forget about it, only about 20% were no longer on this divorce. Then another group introduced sodium valproate 100 mg / kg 30 minutes before the bead thrown, they swallowed - threw the 2nd time in 24 hours - not wilt for about 60%. 300% improvement in comparison with the control.

It's a simple illustrative example. Already we have an understanding of what is happening through the CREB-protein complex.

- Sodium butyrate (GHB). Located in the 3rd list of banned substances, not so long ago, it is actively used by junkies, because in addition to the action on the deacetylase, the substance has an effect comparable to the shock dose of alcohol. Continuing with the previous study Anokhin and chickens: butyrate was administered 1.2 g per 1 kg of 3 minutes after the unfortunate experience. Valproate within 30 minutes, and 3 minutes butyrate. After 24 hours storage was better than in the control group is about 2.5 times.

Generally, valproic acid and sodium butyrate, the most often appear in the studies.

- Ladasten. This material was originally focused on dopamine - a neurotransmitter concentration and good mood. Dopamine increases from actions Bromantane or Ladasten. With respect to inhibition of histone deacetylase have effect on HDAC1, HDAC3, HDAC4.

After 1 hour after the rats ate Ladasten 50 mg to 1 kg, HDAC1 activity in the striatum - is part of the brain was 65% of control, HDAC3 - about 50%, HDAC4 - 90%. After 2-3 hours the level returns to normal. In general, in striatum, hippocampus, hypothalamus picture is different. The hippocampus is important for memory, HDAC3 and HDAC4, the lowest value was about 80% after 2 hours after administration. Inhibition of 20%. It is important to distinguish the course the metabolism of rats and people, so if you decide to take to train, then at least 2-3 hours.

- Sulforaphane. Broccoli extract. Widely known as anti-cancer component. There are many studies in animals and in humans one. Sampling of all 3 people. Mandatory condition - no supplementation during the last 6 months and the lack of acceptance of vegetables for 48 hours. They ate 105 mg of sulforaphane, the equivalent of 570 grams of mature broccoli. All three of inhibiting histone deacetylases pattern was identical. Weakens HDAC3, HDAC4 and HDAC6 by 50-70% by about 6 hours after taking. Even bigger and longer than Ladasten.

The exact dosage for humans has not been established in various sources from 2 to 30 mg, 105 mg accepted although in the above study.
We should also mention about Vitamin B3 or nicotinic acid, there is evidence that it also acts as an inhibitor of histone deacetylase 3 rd class, not to be confused with the 3rd type.

Bottom Line:
Can we consider NZT substances which at times improve long-term memory, or compounds that are structurally similar to the neurotrophic factors that cause nerve cells to grow rapidly, and where are our intelligence? If so, what would be the consequences? Do not turn out like amphetamine in the middle of the last century, when it was very effective means for health, but in fact he is seriously depletes dopamine. Or, as with steroids, which are based testosterone, which as it replaces your testosterone, your ceases produced.
Yes, knowledge, desire and means you can get off even with heroin. But how many people can not even get off a cigarette, nicotine? What happens if a person begins to use the mega-dosage of a 7,8-DHF, which can replace your own BDNF? And then restore it?

So far we have considered the matter, which seemed to increase production, pushing the body, improve memory and attention.
Now NZT-48 knocking on the reality of the inside of the sci-fi movie screen. This is still a fantasy, but then 30 years ago, smartphones were fantastic.

What are the best practices recommendations?

Pay attention to the more secure connections:
- Linoleic acid, DCP-LA which modification has excellent effects on memory in mice.
- Sulforaphane - simple and affordable inhibitor of histone deacetylase 6 hours.
- Ladasten. In order not reproached in advertising, the active ingredient - bromantane or adamatnilbromphenilamine.
- Nicotinic acid, is as glycine can be added to the diet.Read even contraindications to these compounds. And remember the most important human qualities!
Empathy makes the man no less than high IQ. See you later!