Ipamorelin

Pharmacological group: peptides; peptide hormones; growth hormone

Ipamorelin - a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which showed the highest results in the allocation of growth hormone and effectiveness of both synthetic and naturally. Ipamorelin not emit acetylcholine and cortisol in the amounts and concentrations at which allocation of these substances is observed upon stimulation by means of GHRP-2, GHRP-6 and CJC-1295.
Purity (according to HPLC): 99% minimum. Displacement vial: 5 mg
Molecular formula: C38H49N9O5
Molecular Weight: 711.86
Number CAS: 170851-70-4
Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2

Ipamorelin - a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which showed the highest results in the allocation of growth hormone and effectiveness of both synthetic and naturally. Large chemical studies have shown that one of Ipamorelin substances lacking the central dipeptide Ala-Trp, growth hormone releasing petid (GHRP-1). In vitro growth hormone Ipamorelin identified from primary rat pituitary cells with the same potency and efficacy as GHRP-6 (electronic records) = 1.3 +/- 0.4nmol / l and Emax = 85 +/- 5% vs. 2.2 + / -0. A recent study showed that Ipamorelin and its analogs (GHRP-6, GHRP-2, Hexarelin) stimulates the production of growth hormone receptor through grelinovyh receptors, unlike the other group of peptides - GHRH (Sermorelin, GRF1-29, GHRH (1-44) , CJC-1293, CJC-1295). You can also like Bonomarlot.

Rats anesthetized with pentobarbital, Ipamorelin secretes growth hormone with the same potency and efficacy as GHRP-6 (medium effective dose = 80 +/- 42nmol / kg and Emax = 1545 +/- 250ng growth hormone / ml versus 115 + / -36nmol / kg and 1167 growth +/- 120ng / ml hormone). In pigs in the minds Ipamorelin developed a growth hormone with the following indicators: the average effective dose = 2.3 +/- 0.03 nmol / kg and the Emax = 65 +/- 0.2ng growth hormone per ml of plasma. Again, figures are similar to the performance of GHRP-6 (median effective dose = 3.9 +/- 1.4 nmol / kg and the Emax = 74 +/- 7ng growth hormone per ml of plasma). GHRP-2 showed more potent but less effective (= median effective dose of 0.6 nmol / kg and the Emax = 56 +/- 6 GH ng per ml of plasma). Specificity of growth hormone has been studied in pigs. None of the tested stimulants growth hormone did not affect the performance of plasma follicle-stimulating hormone, luteinizing hormone, prolactin and thyroid stimulating hormone. Simultaneous administration of GHRP-6 and GHRP-2 resulted in an increase in plasma cortisol and acetylcholine. Surprisingly, Ipamorelin not allocated acetylcholine or cortisol at levels that are very different from the indicators when stimulated by means of GHRH. A similar effect (with the levels of acetylcholine and cortisol in plasma) was evident even at doses in excess of two hundred times the average effective dosage for growth hormone. In conclusion: Ipamorelin - this is the first agonist GHRP receptor having a selective activation of growth hormone, similar to GHRP-1 activation.