Ibutamoren, Nutrobal (MK-677)

Ibutamoren (Nutrobal, the laboratory code of MK-677, MK-0677 or L-163,191) - growth hormone secretion stimulator accepted inside. Ibutamoren is not peptide is long the operating agonist the receptors.

In a research on healthy young people it has been established that the MK-677 connection strengthens release and supports the high level of concentration in plasma of several hormones, including growth hormone, an insulin like factor of growth-1, at the same time without influencing cortisol level.

Also researches have in public confirmed ability of an ibutamoren to increase the volume of dry muscle bulk and mineral density of bones. Besides, medicine accelerates metabolism, starts lypolisys and can be applied to treatment of obesity. Please pay attention to Epifamin.

Doses

Results of researches showed that doses from 20-30 mg a day show sufficient effect, comparable with injection hormone of growth. After oral application of a dose of 25 mg, Ibutamoren induces the average peak concentration of GR equal of 22.1 mkg/l, and in case of higher dosages higher levels of peak concentration. At the same time, growth hormone stimulation duration after single acceptance constitutes 8 and more hours. The similar duration of development of hormone of growth is very effective for stimulation of development of insulin like factor of growth-1, but negatively affects receptors: there is a down-regulation insulin, receptors and receptors of hormone of growth which is caused by development of resistance and tolerance to this substance. Owing to this fact, in case of everyday acceptance of MK-677 reaction of stimulation of GR weakens for the 4th day. In a week development of GR in response to acceptance of MK-677 almost completely stops and it can be considered as the main minus of this medicine.

Side effects

Some of regular side effects which are connected with the increased growth hormone levels - for example, a sleep of hands, sluggishness, and also increase in appetite.