Etifoxine- Active Substances. Instruction and Application, Dosage

Name: Etifoxine

The Latin name of the substance Etifoxine

Etifoxinum (genus. Etifoxini)

Formula - C17H17ClN2O

Therapeutic agents of Etifoxine:

Anxiolytics

The nosological classification (ICD-10)

F00 Dementia in Alzheimer's disease (G30 +)
F03Unspecified Dementia
G10 Huntington's disease
G46 Vascular syndromes of brain in cerebrovascular diseases
G93.4 Encephalopathy, unspecified
I63 Cerebral infarction
I69 The effects of cerebrovascular disease
Violation orientation unspecified R41.0
R41.3.0 * Reduced memory
S06 Intracranial injury

CAS code - 21715-46-8

Pharmacology

Pharmacological action.

Anxiolytic (tranquilizer). Benzoxazine derivative possesses anxiolytic activity, less sedative effect. Selectively affects the supramolecular chloride channels of the GABA-benzodiazepine-receptor complex hlorionofor, activating the GABA-ergic transmission. You can also like Phenibut.

Pharmacokinetics.

Rapidly absorbed from the gastrointestinal tract, TCmax - 2-3 hours, is metabolized in the liver to form several metabolites, one of which, dietiletifoksin is active.. It penetrates through the placental barrier. T1 / 2 etifoxine - 6 hours dietiletifoksina - 20 hours. Excreted by the kidneys (in the form of metabolites and intact) and intestine.

Indications.

Anxiety, fear, inner tension, irritability, mood decline (including on the background of somatic diseases of cardiovascular nature).

Contraindications. 

Hypersensitivity, shock, myasthenia gravis, severe hepatic failure, renal failure, concomitant use of ethanol, pregnancy, lactation, children's age (18 years). For LF containing lactose (optional): galactosemia, malabsorption syndrome, glucose and galactose, lactase deficiency.

Dosing. 

Inside, squeezed a small amount of water, 50 mg 3 times a day or 100 mg 2 times a day. The course of treatment from a few days to 4-6 weeks.

With missed doses should not double the dose during the subsequent reception.

Side effect. 

Urticaria, angioedema, skin rash, drowsiness (in the early days of admission).

Overdose. 

Symptoms: lethargy, excessive sleepiness.

Treatment: 

symptomatic; gastric lavage.

Interaction.

It enhances the effect of opioids, barbiturates, hypnotics, antihistamines drugs, antipsychotics, and others. PM oppressive central nervous system.

It enhances the effect of ethanol.

Special instructions.

In the period of treatment should refrain from driving and activities potentially hazardous activities that require high concentration and psychomotor speed reactions.

Trading names of drugs with working substance Etifoxine

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