Enerion (Sulbutiamine) tablets - Instructions for Use, Dosage, Side Effects

Pharmacological group: General tonic and adaptogens.

Synonyms: Acralion, Arcalion, Arcatamin, Arnion, Enerion, Megastene, Pymeacolion, Sulbutiamina Colmed, Sulbutiamina La Santé, Surmenalit.

Active substance: Sulbutiamine.

ATC A11DA02 Sulbutiamin.

Sulbutiamine (brand name: Arcalion) is a synthetic derivative of thiamine (vitamin B1). As a dimer of two modified thiamine molecules, it is a lipophilic compound that crosses the blood–brain barrier more readily than thiamine and increases the levels of thiamine and thiamine phosphate esters in the brain. Sulbutiamine was discovered in Japan in an effort to develop more useful thiamine derivatives since it was hoped that increasing the lipophilicity of thiamine would result in better pharmacokinetic properties. You can buy Enerion.

Although its clinical efficacy is uncertain, it is the only compound used to treat asthenia that is known to selectively target the areas that are involved in the condition. In addition to its use as a treatment for chronic fatigue, sulbutiamine may improve memory, reduce psycho-behavioural inhibition, and improve erectile dysfunction. At therapeutic dosages, it has few reported adverse effects. It is available for over-the-counter sale as a nutritional supplement.

Composition, structure and packing

Tablets, coated orange, round, biconvex, allowed minor surface irregularities (in degree gloss) staining and the presence of minor inclusions.

Excipients: Corn starch - 12 mg Dried starch paste - 40 mg of glucose (dextrose) Anhydrous - 20 mg lactose monohydrate - 65.5 mg Magnesium stearate - 3.5 mg Talc - 9 mg.

Cover structure: sodium bicarbonate - 0.603 mg, sodium carboxymethylcellulose 0.556 mg, white beeswax - 0.201 mg, titanium dioxide (E171) - 8.43 mg of ethyl cellulose - 0.485 mg sunset yellow FCF (E110) - 3 mg, glycerol monooleate - 0.242 mg, polysorbate 80 - 0.302 mg, povidone - 0.692 mg, sucrose - 106,956 mg colloidal silicon dioxide (Aerosil 130), 28.21 mg of talc.

Pharmacological action

Synthetic compound similar in structure to the thiamine. Sulbutiamine molecule has an open thiazole ring, an additional disulfide bond and lipophilic ester. Thanks to this modification is rapidly absorbed from the gastrointestinal tract and readily crosses the blood-brain barrier.

Unlike thiamine, can accumulate in the cells of the reticular formation, dentate gyrus and hippocampus, as well as in cells and Purkinje fibers glomerul granular layer of the cerebellar cortex.

At a reception Enerion improved coordination of movements and increases resistance to physical stress, boosts stability of the cerebral cortex to repetitive hypoxia.

Pharmacokinetics

Absorption

After ingestion sulbutiamin rapidly absorbed from the gastrointestinal tract, C max in plasma is reached after 1–2 hours

Breeding

T 1/2 is about 5 hours excreted in the urine.

Enerion Dosage

Adult drug administered in a daily dose of 400–600 mg (2–3 tablets.) In 2 divided doses.

The tablets should be taken orally during breakfast and at lunch time.

The duration of treatment should not exceed 4 weeks.

Overdose

Symptoms: excited state with symptoms of euphoria and tremor of the limbs.

Treatment: The symptoms quickly disappear on their own and do not require special treatment.

Enerion Side effects

CNS: tremor, headache, agitation, malaise.

From the digestive system: dyspepsia.

Allergic reactions: possible cutaneous manifestations.

Indications for Enerion

Symptomatic treatment of functional asthenia. Sulbutiamine is indicated for the treatment of asthenia. Asthenia is a condition of chronic fatigue that is cerebral rather than neuromuscular in origin.

Enerion is not recommended in patients with Enerion lactase deficiency, galactosemia or syndrome glucose/galactose malabsorption due to the fact that the substance is formulated with lactose monohydrate.