Encephabol - general information

Pharmacological action - nootropic, metabolic.

Encephabol is a drug that normalizes pathologically impaired metabolic processes in the brain tissues. Encephabol contains the active ingredient pyrithinol. The effect of the drug is based on its ability to increase the uptake and utilization of glucose, as well as increase the release of acetylcholine in the synapses and the exchange of nucleic acids. When encephabol is taken, there is an improvement in cholinergic neuronal transmission.
Thanks to its antioxidant action, pyrithinol helps stabilize the structure of the cell walls of neurons, prevents their damage and improves the function.
When Encephabol is used, there is also an improvement in the rheological properties of the blood, in particular, the plasticity of erythrocytes and the fluidity of the blood increase. The drug improves cerebral blood flow, promotes redistribution of blood flow and increases oxygen delivery to ischemic areas, and stimulates the exchange of glucose in areas of the brain in which ischemic damage was previously identified.
The drug helps to maintain and restore disturbed metabolic processes in the brain tissues, stimulates mental performance, and improves memory.
After oral administration, the active component of the drug is well absorbed in the intestine and reaches peak plasma concentrations within 30-60 minutes. The bioavailability of pyrithinol reaches 76-93%. About 20-40% of pyrithinol binds to plasma proteins. Due to the metabolism of pyrithinol, 2 main metabolites are formed in the liver, which are excreted mainly by the kidneys. About 5% of pyrithinol in the form of metabolites is excreted by the intestine. The half-life of the active ingredient of the Encephabol preparation reaches 2.5 hours, about 74% of the accepted dose of pyrithinol is excreted within 24 hours after taking the drug.
The active ingredient of the Encephabol preparation and its metabolites penetrate through the hematoplacental and blood-brain barrier, and are also excreted in breast milk.

Indications for use
Tablets and suspension Encephabolum is used for symptomatic therapy of patients suffering from chronic impairments of brain functions, which are accompanied by dementia syndromes. In particular, Encephabol is effective in such symptoms of dementia as memory and thinking disorders, decreased concentration and learning ability, increased fatigue, reduced mental performance, and affective disorders.
Encephabol is prescribed for patients suffering from primary degenerative dementia, dementia of vascular genesis, and mixed forms of dementia.
Encephabol in the form of a suspension can be designated as a means of maintenance therapy for patients who have suffered craniocerebral trauma, particularly when the patient has impaired consciousness, cerebral manifestations and insomnia.