Dimephosphone oral solution 15% - General Information

Dimephosphon, Dimephosphone

Pharmacological group:

• Regulators of water and electrolyte balance and acid-base balance;
• Antihipoxants and antioxidants;
• Antiseptics and disinfectants.

Active substance: Dimethyloxobuthylphosphonilmethylate (Dimephosphon, Dimephosphone)

Country of manufacturer: Russia.

ATC V03AX Therapeutic drugs other V03AX.

Pharmacological group: Regulators of water and electrolyte balance and acid-base balance; Antihipoxants and antioxidants; Antiseptics and disinfectants.

Nosological classification (ICD–10)

E87.2 Acidosis;

G35 Multiple Sclerosis;

G43 Migraine;

G45 Transient transient cerebral ischemic attacks [ attack ] and related syndromes;

G90 Disorders of autonomic [ autonomous ] nervous system;

H81.0 Meniere’s Disease;

I10 Essential (primary ) hypertension;

I15 Secondary hypertension;

I27 Other forms of pulmonary heart disease;

I61 intracerebral hemorrhage;

I63 Cerebral infarction;

I67 Other cerebrovascular diseases;

I67.2 Cerebral atherosclerosis;

I67.9 Cerebrovascular disease, unspecified;

I69 Effects of cerebrovascular diseases;

J30 Vasomotor and allergic rhinitis;

J44 Other chronic obstructive pulmonary disease;

J45 Asthma;

J96 Respiratory failure, not elsewhere classified;

J98.9 Respiratory disorders, unspecified;

K13.7 Other and unspecified lesions of oral mucosa;

L08.9 Local infection of the skin and subcutaneous tissue, unspecified;

L20 Atopic Dermatitis;

L21 Seborrheic dermatitis;

L30.9 Dermatitis unspecified;

L70 Acne;

L71 Rosacea;

L98.9 Cutaneous and subcutaneous tissue, unspecified;

M42 Osteochondrosis;

S06 intracranial injury;

T14.1 Open wound of unspecified body region;

T78.4 Allergy unspecified;

Z100 * Chapter XXII Surgical Practice.

Composition, structure and packing

Colorless or yellowish clear liquid with a peculiar odor and bitter taste, pH 2,0–4,0. Easily soluble in water.

Solution for oral and topical use.

Pharmacological action

Antiatsidemic means. Normalizes AAR when acidosis various etiologies - due to the activation of metabolic mechanisms of its regulation (especially kidney and lung), blood flow and strengthen intraorganic tissue metabolism. Has vasodilating effect on the brain vessels, nootropic, anti-depressant, anti, anti-ischemic, stress protective, and mnemotropnoe antiamnesic, antiallergic, membrane stabilizing, immunomodulatory, Antihypoxanth, antimutagenic and radioprotective effect, inhibits platelet aggregation, stimulates tissue regeneration. Dose-dependently reduces the intensity of lipid peroxidation, inhibits spontaneous and ADP-induced aggregation of platelets increases antioxidant activity and reduces the content of lipid peroxidation products. Improves cerebral blood circulation, normalizes the tone of cerebral blood vessels and blood circulation in the brain, improves venous outflow.

Neurotrophic activity and cerebroprotective properties are due to the influence on the mechanisms of brain protection neurometabolic (normalizes carbohydrate and energy metabolism, prevents lipid peroxidation, increases the activity of antioxidant enzymes in the brain tissue). In traumatic brain injury has a beneficial effect on its metabolism and electrical activity, eliminates vasomotor cephalalgia, reduces oxygen consumption by the brain tissues, heart and respiratory failure of central origin, promotes regression of focal hemispheric and stem symptoms.

Eliminates allergic inflammation, particularly in the development of intolerance reactions leuko-triene-dependent sulfites, reduces the severity of the manifestations of atopic asthma and atopic dermatitis. You can also like Cerluten.

In the complex with vitamins, pancreatic enzymes and kolestiramin in children with hereditary entero-oksaluric syndrome slows the progression of the disease.

When applied topically, has an antiseptic effect, increases the protective function of the skin and mucous membranes.

Pharmacokinetics

After a single oral absorbed adequately. Time to reach C max - 2–2.5 hours Easily penetrates the blood-tissue barriers and distributed to various organs and tissues. The greatest concentrations are in the spleen, brain and erythrocytes.

Dosage

Inside (students should drink milk, fruit juice, sweet tea, has a bitter taste), 30–50 mg/kg 1–4 times/day: violations of cerebral circulation and Meniere’s syndrome - within 1–4 weeks., During planned neurosurgical operations - 5 days before and 10–14 days after the operation, when TBI - 3–8 weeks., with autonomic dysfunction, respiratory diseases, acidosis, atopic asthma (in children) - 2–4 weeks., for the prevention of exacerbation hay fever - 3 weeks. before the expected seasonal deterioration and during flowering plant allergen.

Topically applied in infectious and inflammatory and allergic diseases of the skin and mucous membranes - in the form of bandages, turundae and lotions with a solution daily for 3–14 days for the prevention of radiation mucositis - gauze, moistened with a solution, fit the projection beams of radiation for 20 min before the exposure dose.

IV: jet injected 1–4 times/day for 7–10 days. Dose is determinated individually.

Drug Interactions

Enhances the antiplatelet effect of aspirin.

Side effects

If ingestion: possible - nausea, vomiting, heartburn, diarrhea.

At the beginning of treatment: drowsiness.

Indications

Acidosis with pneumonia, chronic nonspecific lung diseases, SARS, diabetes and postoperative; bronhospastic variant of bronchial obstruction (chronic bronchitis, bronchial asthma, including atopic asthma in children), subcompensated hypertension in the pulmonary circulation, hay fever in children, transient ischemic attack, ischemic and hemorrhagic stroke (initial manifestations, consequences of previous stroke), encephalopathy (including on the background of hypertension and neuro dystonia), myelopathy, radiculopathy; neurosurgical operative trauma of the brain and spinal cord injury, traumatic brain injury (concussion and brain contusion), and Meniere’s syndrome, autonomic lability. Atopic dermatitis, infectious and inflammatory diseases of the skin and mucous membranes: acne, erysipelas, purulent-inflammatory complications in places out of the spokes Ilizarov apparatus, diseases of ENT and dental, mucositis during radiation therapy of malignant tumors, infected wounds, sores, rickets disease in children, hereditary entero-oksaluric syndrome.

Contraindications

Chronic renal failure and moderate to severe epilepsy, hypersensitivity to Dimephosphon.

Cautions

When the sleepiness refrain from driving vehicles and occupation, requiring special attention and speed of psychomotor reactions.