Cycloferon tablets - Instructions for Use, Dosage, Side Effects

Cycloferon is the universal antiviral preparation with direct antiviral, immunocorrecting, and anti-inflammatory activity. Cycloferon reinforces the body nonspecific resistance to viral and bacterial infections.

Cycloferon enteric-coated tablets 0.15 g

Brand name: CYCLOFERON

Dosage form: Enteric-coated tablets.

Therapeuctic category: Immunomodulating factor (inducer of interferon).

Pharmacotherapeutic group: immunostimulatory agent.

Composition:

One tablet contains:

active ingredient - meglumine acridone acetate based on acetic acid-acridone - 150 mg; excipients: Povidone - 7.93 mg Calcium stearate - 3.07 mg hypromellose - 2.73 mg Polysorbate 80 - 0.27 mg of methacrylic acid ethyl acrylate copolymer - 23.21 mg Propylene Glycol - 1.79 mg .

Description: yellow biconvex tablets, enteric coated.

Pharmacological properties

Cycloferon is a low molecular weight inducer of interferon with expressed interferonogenic activity prolonged for 3 days, which defines a wide range of its biological activities (antiviral, immunomodulating, anti-inflammatory, etc.).

CYCLOFERON is effective at viral hepatitis, influenza, herpes, cytomegalovirus, HIV, papilloma virus and other viruses. The preparation possesses direct antiviral effect by inhibiting of viral replication at early stages (1-5th days) of infection, reducing infectivity of virus progeny, resulting in formation of defective viral particles. CYCLOFERON® increases nonspecific viral and bacterial infections resistance. Please pay attention to Pinealon.

Pharmacodynamics.
Cycloferon is an interferon inducer is a small molecule, which defines a wide range of its biological activity (antiviral, immunomodulatory, anti-inflammatory and others.).
Cycloferon effective against herpes viruses, influenza and other pathogens of acute respiratory diseases. It has a direct antiviral effect by inhibiting viral replication in early pregnancy (day 1-5e) infection, reducing the infectivity of viral progeny, resulting in formation of defective viral particles. It increases non-specific resistance of the organism against viral and bacterial infections.

Pharmacokinetics.
When receiving a daily dose maximum plasma concentration is reached after 3.2 hours, gradually decreasing the 8th hour and after 24 hours Cycloferon detected in trace amounts. The half-life is 4-5 hours, so the use of Cycloferon drug in recommended doses, does not create conditions for accumulation in the body.

Indications
In adults in the treatment of:
influenza and acute respiratory infections;
herpes infection.
Children from the age of four in the treatment of:
influenza and acute respiratory infections;
Herpes infection.
Children ranging from four years for the prevention of influenza and acute respiratory diseases.

Contraindications
Pregnancy, lactation, children under 4 years of age (due to imperfect act of swallowing), hypersensitivity to components of the drug, decompensated cirrhosis.

Precautions
When the digestive organs diseases in acute stage (erosion, gastric ulcer and / or duodenal ulcers, gastritis and duodenitis) and allergic reactions in history be sure to consult with your doctor before taking the drug.

Dosing and Administration
Inside, once a day, 30 minutes before a meal, without chewing, with 1/2 cup of water, in the age dosages:
children 4-6 years: 150 mg (1 tablet) for reception;
children 7-11 years: 300-450 mg (2-3 tablets) at the reception;
adults and children over 12 years: 450-600 mg (3-4 tablets) at the reception.
Repeated course it is advisable to spend 2-3 weeks after the end of the first course.

In adults:
1. In the treatment of influenza and acute respiratory diseases take medication for 1, 2, 4, 6, 8 th day (the course of treatment - 20 tablets). Treatment should begin at the first sign of the disease.
In severe influenza during the first day of taking six tablets. At need further spend symptomatic therapy (antipyretics, analgesics, expectorants).

2. When herpes infection take medication for 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23, and day (treatment of 40 tablets). Treatment is most effective when the first symptoms of the disease.

Children from the age of four:

1. With flu and acute respiratory diseases take medication in doses at ages 1, 2, 4, 6, 8, 11, 14, 17, 20, 23 hours. The course of treatment is from 5 to 10 methods, depending on the severity of the condition and the severity of clinical symptoms.

2. In the preparation of HSV infection to take 1, 2, 4, 6, 8, 11, the 14th day of treatment. The course of treatment may vary depending on the severity of the condition and the severity of the clinical symptoms.

3. For emergency non-specific prevention of influenza and acute respiratory infections (in direct contact with patients with influenza or acute respiratory disease of another etiology, during a flu epidemic): 1, 2, 4, 6, 8 th day. Next, perform a break of 72 hours (three days) and continue the course of 11, 14, 17, 20, 23 rd day. The general course is from 5 to 10 receptions.

Cycloferon Interaction with other drugs
Cycloferon compatible with all drugs used in the treatment of these diseases (interferons, chemotherapeutic, symptomatic drugs, and others.). It enhances the action of interferon and nucleoside analogues. It reduces the side effects of chemotherapy, interferon.

special instructions for Cycloferon
Cycloferon does not affect the ability to drive.In diseases of the thyroid gland should consult endocrinologist.
If the reception of the next dose is missed, it should be as soon as possible without regard to the time interval and doubling the dosage to continue the course started on the scheme.
In the absence of the therapeutic effect is necessary to consult a doctor.

Cycloferon - Smart medicine for influenza and SARS

Every day, bacteria and viruses attack our bodies. And if the bacteria immune system manages to cope and to prevent progression of the disease, the virus of the case is much more complicated. They get into our body's cells, turning them into their "laboratory" for the production of new viral progeny. Processes that launches a viral infection that can have a negative impact on any living organism!

What is influenza virus or look through a microscope

Virus (including influenza) - is an intracellular parasite. He was not able to lead a full life outside the cell "master". Whether animal or human. According to their structure, viruses - it is packed into the shell genetic information. Once in the living organism, they introduce their DNA in healthy cells, which begin to "work on the virus" producing viral progeny.

Scientists have recovered more than 200 types of viruses - SARS agents. Influenza can occur in different ways and cause complications. Experts distinguish between two kinds of complications manifested by the lungs (pulmonary) and manifested by other bodies. If the first dangerous pneumonia and rhinitis, the second type of complications can cause a number of serious diseases, up to toxic and allergic shock. Therefore, the flu or SARS should not be allowed to take their course. Treatment of these diseases is necessary to begin with the very first appearance of symptoms.

The first signs of alarm

The symptoms of influenza are known to everyone. Typically, the disease begins suddenly with a sharp rise in temperature. Most often on the second day of illness there is a dry exhausting cough, runny nose may begin. Flu is always accompanied by pain in muscles and joints, and severe headache.

Complications of influenza

Influenza can occur in different ways and cause complications. Experts distinguish between two kinds of complications manifested by the lungs (pulmonary) and manifested by other bodies. If the first dangerous pneumonia and rhinitis, the second type of complications can cause a number of serious diseases, up to toxic and allergic shock. Therefore, the flu should not be allowed to take their course. Treatment of this disease should be started with the appearance of the very first signs.

At the first sign of illness, seek medical advice

Symptoms caused by viral infection is different, and the clinical picture of the disease is able to confuse even a person with medical training. At this stage it is very important not to succumb to self-medicate and do not listen to questionable advice. It is necessary to immediately consult a doctor.

An experienced doctor knows that it requires a "smart" drug that can not only detect the virus, but also enhance antiviral immunity.

Cycloferon Smart medicine against influenza viruses

So clever medicine is Cycloferon. Cycloferon is effective against herpes viruses, influenza and other pathogens of acute respiratory diseases.

Cycloferon has a direct antiviral effect (fights against the virus itself, inhibiting its reproduction) and stimulates the natural protective factors of the organism, thereby "triggering" its own human immune system, which is also struggling with the virus. That is, treatment of viral infection occurs in two ways.

Application Cycloferon helps to reduce the period of the disease, reduce the risk of complications. Cycloferon also possesses anti-inflammatory action. This ensures maximum protection of the body of the flu.

Cycloferon has no effect on the liver rapidly excreted, it does not reduce the therapeutic effect even with frequent use. Drug approved for use in adults and children 4 years of age.

Cycloferon - Blocking the activity of viruses
Everyone is familiar with the symptoms of influenza and other acute respiratory viral infections, but few people know what happens in the body. To understand how to be treated for the flu, it is important to think of the process of infection of the body at the cellular level.
How the infected cell
To begin with let us recall that the virus - it is not a full body and a biological particle, which is necessary for the reproduction of the "boss". That "master" can be a cell in the human body. When the virus enters the healthy cell, it modifies the work cell so that it begins to produce viral progeny. Scientists have found that one infected cell is capable of 8 hours make up to 1000 viral particles. With the penetration of infection in the body is infected with not just one but a plurality of cells. This process of infection explains the rapid development of the disease.

To successfully fight the viral infection is necessary to use not only the products, removing symptoms (headache, runny nose, sore throat, fever) but the drug stops viral replication process - Cycloferon.

Cycloferon prevents the growth of viruses
Cycloferon suppresses propagation of virus particles, thereby forming so-called defective viral particles (DI particles) which do not have infectious ability simply excreted.

Cycloferon block the multiplication of viruses and prevents their activity.
The antiviral effect Cycloferon (active ingredient - acridone acetate meglumine) is universal for different types of viruses. Cycloferon effective against herpes viruses, influenza and other pathogens of acute respiratory diseases.

Cycloferon reduces illness
Thanks to these properties, the use of Cycloferon accelerates convalescence. The disease occurs more easily and reduces the risk of complications in adults and children.

Cycloferon Dosage for Treatment Flu and SARS

In the treatment of uncomplicated flu and SARS adults should take 4 tablets once Cycloferon 1, 2, 4, 6, 8 days of treatment. In case of complications should continue receiving Cycloferon in the same doses at 11,14, 17, 20 and 23 days of treatment.

Cycloferon approved for use with children 4 years of age. Children from 4 to 6 years appoint 1 tablet, with 7 to 12 years 2-3 tablets a day for adults and children from 12 years: 3-4 tablets. Cycloferon should be taken once in the morning, on an empty stomach, without chewing.

Emergency prevention and strengthening immunity

At the height of the epidemic season it is very important not to catch the flu or SARS. Especially if there are children in the immediate vicinity. Children's immune system is quite volatile, reacts particularly acute on pathogens.

Our immune system is designed in such a way as to protect the body from external infections. However, for various reasons, the body's defensive reaction is delayed, and disease during that time can "gain traction". This may be due to the weakening of the immune system: due to stress, an unbalanced diet, climate change, etc. The virus itself also able to reduce the protective functions of the body. To fight the virus as soon as possible is used antiviral drugs that can quickly stop the multiplication of viruses.

How does Cycloferon act?

Functions of the immune defense cells are very diverse. Some of them are designed to produce interferons.

By their nature, interferon is a protein related to the innate immune system. He performs the first line of defense in response to the invading virus particles.

Cycloferon stimulates rapid production of interferons own body. We should not be afraid of an overabundance of interferon. In the body there is a mechanism to control the production of interferon, which is activated when the required level of interferon in the blood and their development stops.

Cycloferon - fast inducer of endogenous interferon

Molecule Cycloferon (active ingredient - acridone acetate meglumine) affects the immune system cells responsible for the production of interferon - macrophages. And they begin to produce interferon. Within 2 hours after ingestion maximum observed antiviral activity of the immune system. This "interferon barrier" prevents the penetration of viruses into the cells of the body and does not give the virus a chance to multiply.

What is "emergency prevention"

The use of the drug in order to prevent the disease in the event of contact with the ailing person and (or) during the epidemic called "emergency prevention". Application Cycloferon for emergency prevention of influenza and acute respiratory viral infection reduces the risk of disease.

Studying the effectiveness of Cycloferon for the purpose of prevention of influenza and acute respiratory viral infections in adults and children

Study the effectiveness of Cycloferon for the prevention of influenza and acute respiratory viral infections was conducted on the basis of various medical institutions.

results of the Cycloferon study

Children. Influence Cycloferon to reduce the incidence of influenza and acute respiratory viral infections in young patients it has been experimentally proven in clinical studies to increase the natural resistance (resistance to the virus) children for the prevention of influenza and SARS. The study involved 17,520 children aged 4 to 16 years. The results showed that the application of Cycloferon incidence of influenza and acute respiratory viral infection of young children has decreased by 7.2 times, and older - 2.9 times.

Adults. A similar clinical study was conducted and with adults aged 18-25 years. The study involved 3717 people.

As shown by the test results, Cycloferon reduces the incidence of adult influenza and SARS in 3,5 times.

Cycloferon approved for use in adults and children from 4 years.

Cycloferon - study effectiveness
Every year we are faced with the problem of influenza and SARS. For successful treatment of viral diseases at the first sign of infection is important not to lose time, immediately began administering an effective drug that could not only block the activity of viruses, without causing harm to the body, but also improve immunity.

One of these drugs is Cycloferon. It is able to solve the challenge to address the causes of influenza and acute respiratory viral infections, reduce the risk of complications and recovery of the body's own protective functions. Due to its effect on the body Cycloferon approved for use not only in adults but also in children from 4 years.

Before using any drug is advised to carefully read the instruction, which is approved by the Ministry of Health on the basis of comprehensive scientific tests. For each application Cycloferon action is a series of clinical trials. Conducting such research is a prerequisite to ensure that the drug came to the pharmacy windows. However, after the tests required for registration, Cycloferon efficacy studies have been going on for over 20 years.

The evidence base
Cycloferon can be proud of the scale and quality of research conducted over many years of its implementation and proving its effectiveness. The Scientific Medical Library of Congress has published about 200 experimental, clinical and scientific papers devoted to the study of the efficacy and safety Cycloferon for various viral diseases. Cycloferon included in the list of vital and essential drugs in the Russian Federation, as well as standards of treatment of influenza of varying severity, in both adults and children.

Application Cycloferon for the purpose of prevention of influenza and acute respiratory viral infection contributes to a marked decrease in morbidity among adults and children
Children. Influence Cycloferon to reduce the incidence of influenza and SARS young patients it has been experimentally proven in clinical studies to increase the natural resistance (resistance to the virus) children for the prevention of influenza and SARS. The study involved 17,520 children aged 4 to 16 years. The results showed that the application of Cycloferon incidence of influenza and acute respiratory viral infection of young children has decreased by 7.2 times, and older - 2.9 times.
Adults. This clinical trial was carried out and in adults aged 18-25 years. The study involved 3717 people.

As shown by the test results, Cycloferon reduces the incidence of adult influenza and SARS in 3.5 times.

Cycloferon Application for the treatment of influenza and acute respiratory viral infections in adults and children significantly reduces the likelihood of disease and complications
Children. In a clinical study, devoted to the treatment of influenza and acute respiratory viral infections in children attended 122 children from 4 to 14 years.

Cycloferon shortens:
febrile reaction in 2.0 times
rhinitis and pharyngitis 2.0 times
cough 1.5 times
wheezing in the lungs by 1.7 times

As the results of studies of children Cycloferon 2 times reduces the periods of elevated temperature, the manifestations rhinitis and pharyngitis and 1.5 times - during cough symptoms. The results indicate that Cycloferon effective in reducing the incidence and severity of symptoms of influenza and SARS, preventing development and reducing the severity of complications.

Adults. In this clinical study, adults who took part in 522 people aged 18-20 years. Of these, 320 people were diagnosed with moderate forms of influenza A (H1N1). The results of the study, Cycloferon in treatment of H1N1 influenza and SARS greatly improves the quality of the treatment process, and speeds recovery. At the same time it changes the structure of the flu, including the H1N1 flu, and SARS in the predominance of pulmonary forms of the disease. In particular, Cycloferon reduces the intensity and duration of the reaction temperature, and in combination with symptomatic means 9 (!) Times reduces the incidence of influenza and SARS complications such as pneumonia and bronchitis.

Cycloferon not have a detrimental effect on the body
The study devoted to the impact of Cycloferon on the body, has shown that the drug has no negative impact on vital organs, particularly the liver, t. To. Is not metabolized in it. It does not stay in the body and excreted by the kidneys in an unmodified form within a day after the reception.

Admission Scheme of Cycloferon (tablets) at influenza and SARS:
Prevention of influenza and acute respiratory viral infections (extra and seasonal): reception 1 times a day, in the age dose 30 minutes before a meal without chewing.

Days of reception: 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23.

General rate - from 5 to 10 receptions. The course may extend for another 5 receptions at intervals of 1 every 3 days for a doctor's recommendation.

Treatment of influenza and SARS: reception 1 times a day, in the age dose 30 minutes before a meal without chewing.

Days of reception: 1, 2, 4, 6, 8.
Age-dose on reception

Children 4-6 years: 1 tablet per reception
Children 7-11 years: 2 tablets at reception
Children from 12 years and adults: 4 tablets. In severe influenza during the first day of taking 6 tablets.
Contraindications: pregnancy, breastfeeding, children under 4 years (due to imperfect act of swallowing), hypersensitivity to components of the drug, decompensated cirrhosis.

Cycloferon Treatment of influenza and SARS
Presumably, the name of the disease "influenza" comes from the German word "Grips", which means the pharynx, or throat from the English word "grip" to twist, grasp (of the disease). Influenza is part of a group of acute respiratory viral infections (ARI) and regularly distributed in the form of epidemics. As a rule, the disease develops rapidly, suddenly and violently. More morning person can go out completely healthy, and in the evening come back with fever and aching muscles and joints. What is the cause of poor health?

Influenza Pathogens
Scientists have recovered more than 200 species of SARS agents. The causative agents of influenza - is three kinds of virus (type A, type B and type C). All three types of influenza virus are different in structure. Over the years, the evolution of man has learned to produce immunity to a specific type of virus. This feature of the immune system has helped people to survive for centuries. But not all so simple! Develop immunity against one type of influenza virus "does not work" against another. Furthermore, viruses of the same type (particularly of type A) are able to quickly mutate and change their structure. As a result, new forms of influenza viruses are produced every year, unknown to our immune system. That's why most people get the flu each year.

The first signs of alarm
The symptoms of influenza are known to everyone. Typically, the disease begins suddenly with a sharp rise in temperature. Most often on the second day of illness there is a dry exhausting cough, runny nose may begin. Flu is always accompanied by pain in muscles and joints, and severe headache.

Complications of influenza
Influenza can occur in different ways and cause complications. Experts distinguish between two kinds of complications manifested by the upper and lower airways, and manifested by the other organs. If the first dangerous pneumonia and rhinitis, the second kind of complications can cause a number of serious diseases, up to toxic and allergic shock. Therefore, the flu should not be allowed to take their course. Treatment of this disease should be started with the appearance of the very first signs.
At the first sign of illness, seek medical advice

Symptoms caused by viral infection is different, and the clinical picture of the disease is able to confuse even a person with medical training. it is very important not to succumb to self-medicate and do not listen to questionable advice at the first signs of the disease. It is necessary to immediately consult a doctor.

An experienced doctor knows that the flu and acute respiratory viral infections requires "smart" drug that can not only fight the virus, but also enhance antiviral immunity.

The secret to treat influenza and SARS
Influenza is a serious disease, so he felt the first symptoms, you should immediately take steps antiviral defense. There are a number of drugs aimed at the treatment of viral infections. One of these drugs is Cycloferon, release tablet form.

Cycloferon has a direct antiviral effect (fights by the virus), it stimulates a person's own immune system, which is also struggling with the virus. That is, treatment of viral infection occurs in two ways.

Application Cycloferon helps to reduce the period of the disease, reduce the risk of complications. Cycloferon also possesses anti-inflammatory action. This ensures maximum protection of the body of the flu.

Cycloferon no effect on the liver rapidly excreted, it does not reduce the therapeutic effect even with frequent use. The drug is approved for use in adults and children 4 years of age.