Cyanocobalamin - Interactions with other Active Compounds

Cyanocobalamin + Aminosalicylic acid + Isoniazid

Aminosalicylic acid interfere with the absorption of cyanocobalamin (vitamin B12) (risk of anemia). B12 vitamin absorption when receiving aminosalicylic acid 5 g of 55% broken, which leads to significant changes of erythrocytes. Thus, in patients aminosalicylic acid (as part of a combination aminosalicylic acid, isoniazid +) requires more than 1 month therapy with vitamin B12.

Cyanocobalamin + Ascorbic acid

Cyanocobalamin is pharmaceutically incompatible with ascorbic acid.

Cyanocobalamin + Glutathione

Avoid joint use of glutathione with cyanocobalamin.

Cyanocobalamin + lansoprazole

On the background of slowing down the absorption of lansoprazole cyanocobalamin.

Cyanocobalamin + Cyanocobalamin + mesalazine

Against the background of mesalazine slows down the absorption of cyanocobalamin.

Cyanocobalamin + Sodium thiosulfate

Sodium thiosulfate chemically incompatible with cyanocobalamin, which is why they can not be administered via the same device for the on / in.

Cyanocobalamin + neomycin

Neomycin for oral administration may reduce the absorption of vitamin B12 for oral administration, leading to a weakening effect.

Cyanocobalamin + neostigmine

If concomitant use of cyanocobalamin in large doses reduces the effect of neostigmine.

Cyanocobalamin + pemetrexed

The pharmacokinetics of pemetrexed do not change under the joint application of folic acid inside.

Cyanocobalamin + Pyrazinamide Prothionamide + + + Rifabutin [Pyridoxine]

Pyridoxine (consisting of a combination of pyrazinamide protionamid + + + rifabutin [pyridoxine]) pharmaceutically incompatible with cyanocobalamin.

Cyanocobalamin + pyridoxal phosphate

The solutions are not compatible.

Cyanocobalamin + Pyridoxine

Cyanocobalamin is pharmaceutically incompatible with pyridoxine (as contained in the molecule of cyanocobalamin cobalt ion destroys this vitamin).

Cyanocobalamin + Pyridoxine

Pyridoxine pharmaceutically incompatible with vitamin B12.

Cyanocobalamin + Riboflavin

Cyanocobalamin is pharmaceutically incompatible with riboflavin (as contained in the molecule of cyanocobalamin cobalt ion destroys this vitamin).

Cyanocobalamin + Thiamine

Cyanocobalamin is pharmaceutically incompatible with thiamine (as contained in the molecule of cyanocobalamin cobalt ion destroys this vitamin).

The risk of allergic reactions is increased by combined use of cyanocobalamin with thiamine.

Cyanocobalamin + Thiamine

Not recommended simultaneous parenteral administration of thiamine and cyanocobalamin (vitamin B12): Vitamin B12 enhances the allergenic effect of thiamine.

Cyanocobalamin + Chloramphenicol

Chloramphenicol in the combined use reduces the hematopoietic effect of cyanocobalamin.

Cyanocobalamin + Emoxypine + [Pyridoxine]

Pyridoxine (consisting of a combination emoxypine + [pyridoxine]) pharmaceutically incompatible with cyanocobalamin.