Cyanocobalamin- Active Substances. Instruction and Application, Dosage

Name: Cyanocobalamin

The Latin name of the substance Cyanocobalamin

Cyanocobalaminum (genus. Cyanocobalamini)

chemical name alpha- (5,6-dimethylbenzimidazole) cyanide cobamide

Formula - C63H88CoN14O14P

Therapeutic agents of Alprazolam: Vitamins and vitamin-like agent; Stimulants hemopoiesis

The nosological classification (ICD-10)D51 Vitamin-B12-deficiency anemia
D61 Other aplastic anemia
E53.8.1 Lack of vitamin B12 (Cyanocobalamin, Methylcabalamin)
G12.2 Motor neuron disease
G35 Multiple sclerosis
G50.0 Trigeminal neuralgia
G54.1 Disorders of lumbosacral plexus
G54.6 Phantom limb syndrome with pain
G62 Other polyneuropathies
G63.2 Diabetic polyneuropathy (E10-E14 + with common fourth character .4)
G80 Cerebral Palsy
G95 Other diseases of spinal cord
K52 Other noninfectious gastroenteritis and colitis
K73 Chronic hepatitis, not elsewhere classified
K74 fibrosis and cirrhosis
L13.0 Dermatitis herpetiformis
L20 Atopic dermatitis
L40 Psoriasis
L56 Other acute skin changes caused by ultraviolet radiation
M79.2 Neuralgia and neuritis, unspecified
Q90 Down's syndrome

CAS code - 68-19-9

Pharmacology
Mode of action - hematopoietic, erythropoietic, antianemic, metabolic.

It has a high biological activity and is involved in carbohydrate, protein, lipid metabolism. Increases the regeneration of tissues, normalizes blood, liver and nervous system, activates blood clotting, lower blood cholesterol (atherosclerosis). In the body (primarily in the liver) becomes a cofactor - cobamide, part of many enzymes, including of the reductase, reducing folic acid tetrahydrofolic. Cobamide participates in the transfer of methyl and other one-carbon fragments and therefore necessary for the formation of deoxyribose and DNA creatine, methionine - donor of methyl groups in the synthesis of lipotropic factor - choline to convert methylmalonic acid in amber, which is composed of myelin, for recycling propionic acid. It contributes to the accumulation in erythrocytes of compounds containing sulfhydryl groups, which explains the increase in their tolerance to hemolysis. You can buy - Vitamin B12 cyanocobalamin injection.

Absorption takes place throughout the small intestine (partly in thick). The ileum is connected with a special intrinsic factor and intestine becomes unavailable to micro-organisms; complex in the small intestine wall transmits cyanocobalamin receptor, which transports it into the cell (receptor activity depends on the structure and functions of mucosa supported folic acid, as well as the presence of calcium ions from the medium and pH). In the blood, it binds to vitamin B12 transcobalamin I and II, which transport it to the tissues. Deposition occurs primarily in the liver, the liver is derived from the bile into the intestine and is absorbed again. Elimination occurs mainly by the kidneys.

Application of the substance Cyanocobalamin

Chronic anemia occurring with the deficiency of vitamin B12 is (Addison - Birmera, alimentary macrocytic), in the treatment of anemia - iron deficiency, post-hemorrhagic, aplastic caused by toxic substances and drugs, myelosis, traumatic injuries and inflammatory peripheral nerve processes (wound radiculoneuritis, neuritis , neuralgia, causalgia, phantom pain), amyotrophic lateral sclerosis, encephalomyelitis, multiple sclerosis, diabetic neuropathy, cerebral palsy, Down's syndrome, skin diseases (psoriasis, photodermatosis, dermatitis herpetiformis, neurodermatitis), traumatic injuries of the bones, and conditions after surgeries on locomotor system during deceleration of bone consolidation, acute and chronic hepatitis, cirrhosis, radiation sickness. For prophylaxis - the appointment biguanide, p-aminosalicylic acid, high doses of vitamin C in the pathology of the stomach and intestines, preventing the normal absorption of vitamin (resection of the stomach, small intestine, Crohn's disease, celiac disease, sprue).

Contraindications

Hypersensitivity, hypercoagulation (including acute thrombosis) erythremia, polycythemia.

Restrictions to application

With caution and in lower doses prescribed for angina, benign and malignant tumors (used only in cases involving megaloblastic anemia and a deficiency of vitamin B12).

Side effects of Cyanocobalamin substance
Headache, dizziness, agitation, pain in the heart, tachycardia, allergic reactions (urticaria).

Interaction
Pharmaceutically (one syringe) incompatible with solutions of vitamins, B1 and B6 (cobalt ion contributes to the destruction of other vitamins). It increases the likelihood of allergic reactions caused by vitamin B1.

Dosing and Administration of Cyanocobalamin Substances
Inside, n / a, / m, in / in and intra-lumbar. In anemia, Addison - Birmera - 100-200 micrograms a day; for anemia Addison - Birmera with symptoms of funicular myelosis and macrocytarnic anemia with nervous system disorders - 500 micrograms or more per injection (in the first week - every day, and then - the intervals between injections to 5-7 days). At the same time prescribe folic acid. In remission maintenance therapy is administered to the absence of effects on the funicular myelosis 100 mg 2 times a month, and in the presence of neurological phenomena - 200-400 mg 2-4 times a month. When iron and hemorrhagic anemia - at 30-100 mg 2-3 times a week. In aplastic anemia (especially in children) - 100 micrograms before clinical and hematologic improvement. When nutritional anemia in children at an early age and in preterm - 30 micrograms per day for 15 days; in CNS diseases and neurological diseases with pain is administered in increasing doses from 200 to 500 micrograms per injection, and with the improvement in - 100 micrograms per day; Course - up to 2 weeks; traumatic lesions of the peripheral nerves - at 200-400 mcg every other day for 40-45 days. When hepatitis and cirrhosis of the liver - 30-60 micrograms per day or 100 mg every other day for 25-40 days; dystrophy in young children, Down syndrome and cerebral palsy - 15-30 mg a day; when sprue, radiation disease, diabetic neuropathy appoint 60-100 mg daily for 20-30 days. When funicular myelosis, amyotrophic lateral sclerosis, multiple sclerosis is sometimes injected into the spinal canal at 15-30 mcg (gradually increasing the dose to 200-250 mg).

Precautions for Cyanocobalamin substance
During treatment should regularly monitor the blood count and clotting.

Trading names of drugs with working substance CyanocobalaminTrade Name

Vitamin B12
Vitamin B12 Crystal
cyanocobalamin
Cyanocobalamin (Vitamin B12)
Cyanocobalamin bufus
Cyanocobalamin-Vial
Cyanocobalamin Injection
Tsikomin-Altfarm