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PPAR-gamma activators

28 Nov 2016

ัellular kernel floats in liquid cytoplasm in the manner of a crude egg yolk, and all its surface is covered with spots of the sensitive whites called by receptors. Through a cellular cover active agents (scientifically, ligands) which "are pasted" to the chosen receptor filter into cytoplasm and ingenerate the signal exciting the genes which are stored a kernel. Scientists ironically call "orphans" receptors which ligands are unknown. And so, from 200 types of the nuclear receptors known today to science, the majority is "orphan". Geneticists are whipping the cat. They already solved functions of many genes and if to them "key" was found, our life unrecognizably would be changed. Add some Oftalamin to your daily life.

Purposefully influencing genes, we would learn not to be ill, grew up newly the operated bodies and, perhaps, in general would cease to grow old. However, one small miracle already occurred. Scientists found the sensitive site which is connected with metabolism of fats on a kernel. More precisely, this receptor (PPAR-gamma is called) is connected to that part of a genome which operates destruction of subcutaneous fat on a body. If we knew what substance "is able" to influence PPAR-gamma receptor, we could create a unique fat loss. Present, you take a medicine, and in couple of days of fat on a body as didn't happen! Researchers say that they very soon will solve a riddle, and will create the activator (stimulator) PPAR-gamma, and so far accept fats an omega-3. It is known that from them grow thin. Such paradoxical effect of cod-liver oil is explained by the fact that it is capable to influence cellular genes.


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mTOR

28 Nov 2016

mTOR (mammalian target of rapamycin, has also other name - FRAP1) — an intracellular protein which is the signal element regulating development and a hypertrophy of muscle fibers. Now scientists develop activators of this cellular complex for the purpose of their application in bodybuilding.

In case of activation of mTOR there is a stimulation of growth of muscular tissue. Known stimulators of mTOR: factors of growth, amino acid (squirrels), and especially BCAA, Gliatilin. Also mTOR is activated in case of physical activity at trainings.

Article from the Iron Word

How children whose organism doesn't synthesize androgenic hormones yet grow? With it they are helped by genes. However only those kids which are eaten much grow well. Whether only because their organism receives the necessary amount of plastic material for growth? Answering this question, scientists found in cells the special substance mTOR which appears, some kind of, the sensor of wellbeing of a cell. If mTOR reads that the cell prospers, it gives "starting signal" to genes, and those launch process of proteinaceous synthesis and division.

How this cellular complex estimates the state of affairs?

On existence in a cell of insulin, other factors of growth and amino acids (especially a leucine). The more in a cell, the mTOR is more active than this "good". Then that the abundant supply including "sweet" carbohydrates is a direct stimulator of the genes which are responsible for growth of a body. By the way, mTOR activates also an oxidative stress. Just therefore children who in addition frolic in the fresh air much grow better. The same reason is the cornerstone of the phenomenal growth of the teenagers who are seriously doing run and swimming. The last circumstance should be noted to the fans ignoring aerobics. Begin to run, and your genes will recover! As a result aerobic loadings will bring you an increase of muscle bulk! You can try Renisamin.

Scientists promise to create the aim mTOR activator in the near future. The component will allow everyone to return to own childhood and to start over again growing. And so far accept leucine, and also forscolin and zinc. The last two substances stimulate mTOR with sideways. (Remember that zinc is toxic! Accept zinc medicines precisely according to the instruction!)


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Acarbose

28 Nov 2016

Acarbose is a medicine, inhibitor alpha glucosidase, slowing down digestion and an absorption of carbohydrates in a small bowel and, as a result, the reducing body height of concentration of a glucose in a blood after the use of nutrition, and reducing body weight due to decrease of entering of calories. It is better known under the trade name of "Glyukobay" belonging to Bayer AG producer (Germany).

Acarbose

Mechanism of action

Oppressing intestinal alpha glucosidase, reduces enzymatic transformation di - oligo-and polysaccharides to monosaccharide, reducing thereby glucose absorption from intestine and postprandial hyperglycemia, and also reduces body weight. At patients with the broken tolerance to glucose at regular use 2 types, cardiovascular diseases and a myocardial infarction reduce risk of development of a diabetes mellitus. You can also like Renisamin.

Acarbose use development of a hypoglycemia is uncharacteristic. In the researches in vitro and in vivo mutagenicity signs aren't revealed. Introduction with nutrition to rats doesn't influence fertility and the general ability to reproduction.

Regimen of dosage

Inside, without chewing, with a small amount of liquid just before meal or in 1 h after food. An initial dose — 50 mg 3 times a day with gradual augmentation of a single dose to 100 — 200 mg (the augmentation of a dose is carried out in 4-8 weeks of treatment at an interval of 1-2 weeks, depending on the maintenance of a glucose in a blood and an individual acceptability). An average dose at adults with body weight less than 60 kg — 50 mg, more than 60 kg — 100 mg 3 times a day. The maximum daily dose is 600 mg/days.

Prophylaxis: an initial dose — 50 mg of 1 times a day with gradual augmentation of a single dose to 100 mg (the augmentation of a dose is carried out within 3 months).

Side effects

From the alimentary system: epigastric pain, meteorism, nausea, a diarrhea, it is rare — rising of activity of "hepatic" transaminases (at reception in a dose of 150 — 300 mg/days), an intestinal obstruction, an icterus, hepatitis.

Allergic reactions: dermal eruption, hyperemia, exanthema, urticaria.

Others: seldom — edemas.

Analogs

Cheaper analog is drug Voksid.


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Adaptogens and some other natural biologically active agents

28 Nov 2016

The functional shifts arising in various systems of an organism at athletes can be corrected by means of various phytopreparations and other natural biologically active agents (products of beekeeping, a mummy, medicines from horns of wild animals, etc.). It is reasonable to apply these medicines and during the inter competitive period to maintenance of the normal state and high functional readiness of various systems of an organism, before the competitions, during the competitions, to preserving the normal state of the main functional systems in extreme conditions, during the rehabilitation period after the competitions for fast elimination of the arisen negative shifts.

When using medicines of natural biologically active agents it is necessary to follow the following general rules.

1. Only the doctor after comprehensive inspection and establishment of the diagnosis can appoint phytopreparations (and other natural biologically active agents).

2. In case of treatment by herbs (and other natural medicines) it is necessary to organize a normal work-rest schedule, not to smoke and not to accept alcohol.

3. The chair is regulated by additive of the components possessing the fixing or laxative action.

4. During an exacerbation of a disease to accept the "shock" (increased) doses of medicines. Therapy by natural medicines requires quite long period. In case of treatment by grass charges lack of 1 — 2 components reduces therapeutic effect some.

Most reasonablly at various stages of sports activities to use natural adaptogens of phytogenesis is the medicines possessing the toning and stimulating complex action. They can be a vegetable, animal or mineral origin. Their therapeutic effect is shown first of all against the background of exhaustion. Their small toxicity, width of therapeutic action, lack of a phase of a negative after-effect and accustoming owing to prolonged use belong to benefits of natural adaptogens. Now there is rather big material testimonial of their positive action on the healthy people performing hard physical and mental work (including in the conditions of Far North and other severe climatic conditions), on athletes, on the persons weakened by various diseases and harmful effects. Vegetable adaptogens can increase physical working capacity at healthy people (it is considered that generally through nervous and hypophysis of system), resistance of an organism to a hypoxia, radiation, a heat, cold and other negative impacts, they take off effects of fatigue and provide good health. Under their action muscular work is characterized by more economic expenditure of energy resources of an organism, the oxidizing processes connected with phosphorylation amplify, energy exchange, apparently, due to strengthening of aerobic reactions and use as a power source not only carbohydrates, but also lipids improves. One of the Best drug is Ventramin.

In spite of the fact that adaptogens of a plant origin are one of the most widespread OTC medicines and dietary additives to a nutrition, still many doctors treat them indulgently, as insufficiently effective drugs with the unproven mechanism of action. Increased requirements of doping control, and also side effects of some medicines recommended in sports medicine force to reconsider methods of biological standardization and to add them with chromanti-terrorist operation - a mass spectrometry. liquid chromatography, radio immune analysis and others, as well as actual pharmacological activity (carrying out bench experiments) of this numerous group of drugs.

Adaptogens are called natural (mainly vegetable, is more rare than an animal or mineral origin) drugs. These are low-toxiferous biologically active agents (medicinal preparations and dietary additives to a nutrition) which dilate borders of adaptation (adaptation) of the person to extreme factors (to an exercise and mental stress, stresses, a hypoxia, a heat, cold, overcoming the klimatopoyasnykh of zones, all types of radiations, etc.), i.e. increase fastness of an organism to external adverse factors.

At the same time it is necessary to notice that also vitamin drugs can concern to this group. Some metabolism drugs of a synthetic parentage have Adaptogen properties.

Action of adaptogen has to be not specific and is universal, i.e. under its influence fastness to action of the main natural (an exercise stress, a hypoxia, cold etc.) and technogenic (kinetoza, vibrations) extreme factors has to increase. Positive effects at its use have to be carried out due to optimization of metabolic processes, protection of fabric structures against a destruction. Repeated introductions lead to formation of a systemic and structural trace of adaptation.

Cumulative effect for all adaptogens is nonspecific rising of functionality, and also adaptabilities (adaptation) of an organism under the complicated living conditions. Adaptogens practically don't change normal functions of an organism, but considerably increase physical and mental operability, an acceptability of loads, fastness to various adverse factors and reduce terms of adaptation to them.

Adaptogens have complex chemical structure, and it isn't possible to explain their action at the expense of one of components. For example, if the anabolitic effect of levzea can be treated as a result of action of fitoekdisteroid is ekdisten, then the tonic effect isn't bound to it in any way. Therefore it isn't necessary to seek to divide the operating beginnings of vegetable drugs into components as their properties can be lost.

Historical information

Popularity of the herbs improving working capacity is known long since.

"Person root" a ginseng came to us from the Chinese medicine. At the same time, in the last decades new aspects of the mechanism of action are established, its new pharmacological properties are open. Curative effects of maraly root (levzea) learned later, watching marals who looked for this root before marriage fights. The Siberian hunters knew that, having a magnolia vine Chinese, it is possible to do week without nutrition, without losing working capacity. Araliya, the eleuterococcus as medicines was opened in the beginning by inhabitants, and then and scientists of the East and Siberia.

Medicines from horns of deer began to apply in 3700 g to P. X. Further established that the keratin which is available in horns contains a significant amount of sulfur-containing amino acids. In traditional medicine of the countries of East Asia the neogrowing stiff horns (pant) of a dappled deer use more 2000 at attrition, delicacy, anemia.

In general the medicine of India, Tibet, Vietnam, China, Korea, Japan still remains a riddle for the scientific European medicine which won leading line items in the world. Amazing results pulso-, iridology, acupuncture, cauterizations by method of moks, specific types of massage, umashchivaniye, treatments on the basis of knowledge of time of opening of meridians, accounting of 12-year cycles in forecasting of domination of this or that pathology — these and many other aspects of traditional medicine of the countries of Asia already formed the basis of a number of disciplines: bioritmologiya, heliobiologe, acupuncture, manual therapy, etc. However phytotherapy was and remains the basic direction of traditional medicine of all listed countries during many millennia. Founder of heliobiology of L. A. Chizhevsky scientifically confirmed legitimacy of "the Chinese calendar", having proved that in microbiology, biology, epidemiology of infectious and psychosomatic diseases, changes of the psycho emotional status of people, in social processes we face "a terrestrial echo of solar storms" to which approximately 12-year recurrence is peculiar.

The first attempt of the Russian statement of Chzhud-sha (Vosmichlenny tantra of secret oral manuals), the main treatise of the Tibetan medicine, belongs to P. Badmayev (1901), the second - to A. Pozdneev (1908). Both authors have been repressed. Only in 1988 in D. B. Dashiyev's translation the Soviet doctors could examine from Chzhud-sha. Most of heads of the book is devoted to the Tibetan phytotherapy. In 1994 after the London edition "Tibetian medical paintings" also the Russian edition "Atlas of the Tibetan Medicine", the arch of illustrations to the Tibetan medical treatise of the 17th century has appeared. "Blue beryl", explaining heads of Chzhud-sha. The first treatise isn't translated neither into English, nor into Russian languages so far (not to mention Ukrainian). The merit of the Leningrad pharmakognost A. F. Gammerman, K. F. Blinova, D.Yu. Butkus, E. G. Bazaron, S. N. Nikolayev, T. A. Aseeva's Buryat tibetolog and others who within decades identified hundreds of species of the plants applied in the Tibetan medicine is big. For the modern phytotherapist of Chzhud-sha can serve as the reference book not only on an arsenal, but also on the principles of treatment. Also the fact that from many thousands of books on the Chinese phytotherapy to Russian-speaking doctors only single editions of such authors as F. I. Ibragimov, V. S. Ibragimov (1960) are available, to Chkhva Tkhesop (1987), Halmurat Upur, V. G. Nachata (1992) is indicative. The delay syndrome in editions is characteristic also concerning the Chinese phytotherapy (Zhang Chzhuntszin, 1991). Almost in 1000 after writing "The canon of medical science" of Abu Ali ibn Xing has been translated into Russian, and hundreds of works of other representatives of the irano-Tajik medicine wait for the translators. Despite closeness, and also distinctions of schools and systems of phytotherapy, continuity, sometimes full identity of application of a number of plants and their combinations in Greek-Arab-Tajik-Persian, Indo-Tibetan (with its Mongolian and Buryat branches), and also relatives the Chinese, Vietnamese, Korean and Japanese medicine is traced. Along with a community of an arsenal in them also the community of some principles of phytotherapy is found that is traced, for example, in the monumental reference book of Amirdovlat Amasiatsi "Unnecessary for ignoramuses" (15th century). Let's give the basic principles:

  • phytotherapist shall have wider, specially picked up arsenal of herbs;
  • many "bricks", combinations of plants synergists, detoksikant, "tow trucks cleaners", the guides supplementing action of each other, facilitating bioavailability of medicine are picked already up in traditional medicine; perception of these blocks scientific medicine in which the rule of treatment by one plant illegally prevails is necessary;
  • in traditional medicine use mainly edible, food, fodder plants, substitutes of tea, spice; some poisonous - plants from which mediator poisons are emitted — the blockers of various enzymes which constituted fundamentals of modern scientific pharmacology apply very restrictedly; the concept of phyto dietotherapy which hardly is making the way in life on a roadside and even out of scientific medicine on a commercial path of them is created long ago;
  • complex (a combination to other necessary types of therapy), system (but not posimptom), individual (but not as standard) approach to the patient isn't the declaration in phytotherapy of the countries of East and Central Asia — matching of the components of collection suitable the specific patient is considered the highest class of phytotherapy.

It is obvious that observance not only everything, but even the single principles of phytotherapy under our conditions are impossible. Nevertheless, in the former USSR for the first time there were conditions for perception of ideology, the theory, methodology and practice of phytotherapy. There was it thanks to forming of the doctrine about the condition of nonspecific increased resilience (CNIR) of an organism. The theory of SNPS is created by the Soviet pharmacologist N. V. Lazarev (1959) in case of an explanation of increase in resistance of an organism to infections without application of specific vaccines and serums under the influence of medicines of roots of a ginseng and eleuterococcus prickly. Subsequently it was established that organism resilience against the background of classical phytoadaptogens increases not only to infections, but also to a wide number of the damaging, pathogenic agents and impacts: to a hypoxia, hypo - and a hyperthermia, various, including medicines, to toxins, starvation, overloads, an immobilization, radiation. N. V. Lazarev's pupil I. I. Brekhman (1957, 1968), the founder of valueology, for the first time formulated requirements to adaptogens which can be considerably now are expanded even only as a result of ascertaining of various aspects of their efficiency:

  • lack of toxicity, influence on normal parameters of activity and metabolism;
  • increase in resistance to a wide range of infectious diseases, high immunocorrective effect, protivoonkogenny properties;
  • stress - the limiting properties, an obstacle a stress - induced, for example, operational, to metastasis, an immunodeficiency;
  • the powerful detoksikatsionny properties which are shown, for example, concerning the striking TsNS of poisons as causing an anesthesia, and konvulsant, tsitostatik, hepatotoxic poisons and medicines, carcinogens, mutagens, metgemoglobinobrazovatel, etc.;
  • correction of metabolism and its neuroendocrine regulation, in particular carbohydrate, lipidic, proteinaceous exchanges, synthesis of RNA and DNA. For phytoadaptogens typically positive gonadotropny, antidiabetic action with increase in synthesis and ekzotsitoz of insulin; the positive, regulating influence on functions of adrenal glands — a capability to interfere with development of gilokortitsizm in case of steroid therapy, and also to smooth excessive increase in concentration 17-OKC in blood in case of a stress;
  • the ginseng and other classical phytoadaptogens considered long time as an analog of a fenamin and its derivatives i.e. as a working capacity stimulator. From heterogeneous group of adaptogens only the magnolia vine can be regarded as a stimulator. Course and in a smaller measure one-time application of other plants leads to increase in physical endurance, tolerance to physical activities, fitness that isn't followed by the high psychotonic, stimulating action, agitation, sleeplessness. Adaptogens reduce maintenance time, increase efficiency of a hardening, physiotherapy exercises, the liver glycogen saving is promoted for prolongation of functions of bodies (a brain, heart), by mobilization of not esterifies fatty acids as power source in case of physical activities and a stress. Very important difference of adaptogens from derivatives of fenamin and other psychomotor stimulators is increase in their efficiency in process of prolongation of a rate of acceptance and lack of a stage of depletion after a stage of manifestation of the toning action. At last, adaptogens, unlike fenamin and other indirect adrenomimetik, don't cause addiction and dependence.

Classical adaptogens are ginseng (Panax ginseng), araliya high (Aralia elata), araliya heart-shaped (A. cordata), zamanikh high (Oplopanax elatus), eleuterococcus prickly (Eleuterococcus senticosus), acantopanax (Acantopanax sesseliflorus), calopanax seven-bladed (Kalopanax septemlobus), polistsias (Poliscias filicifolia), levzeyu saflorovidny (Rhaponticum cartaimoides; "a maraly root") from Astrov' family, rhodiola pink (Rhodiola rosea), "a gold root" and, at last, magnolia vine Chinese (Schizandra chinensis). Pharmacological properties of classical adaptogens are studied, generally by employees, pupils of N N. V. Lazarev's followers, than and references in scientific literature mainly for their works speak. The theory of the SI of PS is closely closed with the most significant, fundamental theories of medicine and physiology: adaptic and trophic function of a sympathetic nervous system of L. A. Orbeli (1962) and general adaptic syndrome of G. Selye (1960).

Stress-limit properties of adaptogens and many other plants are shown in their ability to distance a stage of attrition and to prolong a resistance stage. They cause the following phenomena:

  • hypertrophies of adrenals interfere;
  • reduce number of erosive lesions of a mucosa of a stomach, that at times it is mechanistic treated (mainly in the literature written by clinicians, but not physiologists or pharmacologists) as "antiulcerous", but not a stress - protective property;
  • reduce loss of mass of a thymus, a lien.

Therefore, phytoadaptogens interfere with development of a triad of Selye characteristic of a depletion stage. Protivoalterativny, anti-destructive action of adaptogens and some other plants isn't limited to influence on a mucous membrane of a stomach and the timiko-lymphatic device. Restriction of amount and weight of damage on their background carries not organotropny, tkanespetsifichny, but system nature and is implemented at the expense of own metabolites, mobilization of cascades of protection of an organism. Permisserami of their action are, for example, the sex hormones, insulin and a RNA polymerase providing anabolic effect of adaptogens, R-endorphins, various tsitokina, natural killers, and also some enzymes (superoxide dismutase) and catecholamines. Reduction of weight of damage of bodies of detoxication, violation of biochemical composition of tissue of liver and decrease in its weight against the background of acceptance of adaptogens, them pankreo-, vazo-, TsNS-protektivnoye action is proved. Classical adaptogens interfere with decrease in mass of heart and formation of zones of a necrosis in a myocardium. The last is confirmed with experiences with entering of marked technetium which accumulating in a myocardium in case of a stress at rats was reduced by rhodiola extract by 2,6 times. The stress-limiting action of adaptogens is confirmed also at the immunological level: broths of roots of araliya, eleuterococcus, rhodiola, levzea normalize products peritonealny macrophages - 1 - and, eliminate stress decrease in sensitivity of macrophages to the stimulating action of stafilokokk, and lymphocytes action of tsitokin in reaction of blasttransformation, prevent reduction of products of antibodies to erythrocytes of a ram, quantity of cells of a spleen. Inclusion in the multicomponent individually picked up charges of an eleuterococcus, araliya, levzea, rhodiola can level completely immune action of tuberculostatic therapy and tubercular intoxication, and also reduce hepatotoxic effects at suffering from tuberculosis lungs and the accompanying hepatitis B and C.

Further development of the theory of SNPS consists in detection of adaptogen properties at quite wide range of the plants belonging to various families and labors. For example, at the majority from 16 neofitsinalnykh (i.e. not pharmaceutical) types of a family of Caragana existence high antidiabetic, by a CNS - gepato-, gastro-, a stress and angioprotektive properties is registered. The last are taped at broths from 12 types and tinctures from 14 types of karagana and expressed not in a smaller measure, than at chemically pure natural bond of Rutinum vasoprotective allowed for a clinical use, but which isn't possessing a series of properties, listed and very significant for sports medicine.

Advantage forms in comparison with natural bond, more expensive and labor-consuming on receiving, is obvious. It is proved that chemically pure natural bonds of different classes (flavonoids, catechols, benzopyrones, sequiterpenes, triterpena, fenolkarbonovy acids, etc.) don't possess a series of the pharmacological properties inherent in simple galen forms. So, they have no preventive and medical effect on models of alloxanic Diabetum, don't prevent loss and don't promote restoration of basic, unconditional and conditioned-reflex forms of behavior of the animals promoting survival of an individual and look in general. Proceeding from the assumption of gale forms ability to korrigirovat not only carbohydrate, albuminous, but also lipide exchange, clinical approbation of efficiency of infusions of multicomponent collectings was carried out. At patients with an atherosclerosis of vessels of a brain high antidislipidemic efficiency of phytotherapy is confirmed. Adaptogen properties, ability to limit the volume and gravity of alteration, to optimize processes of a reparation, in particular neogeneses, are found in the majority of galen forms from 157 — 200 studied species of plants. Some authors among adaptogens consider drugs of an aloe, buds of a birch, lespedetion dichromatic, lilacs Amur, bergenia of tolstolistny, different types of a plantain, glycyrrhiza, dudnik, a peony, maakiya Amur, etc., and also drugs of animal origin, such as Pantocrinum, saytorin, rantorin, tsygapan.

Undoubted further development of the theory of SNPS is detection at a series of flavonoids and the fenolcarbone acids soft properties which are explained by reversible inhibition a catechol. It is about metiltransfere of sympathetic synapses and an obstacle to oxidation of catecholamine. Thus, existence natural, i.e. widespread, regulators of adaptic and trophic function of a sympathetic nervous system is proved.

The Chinese and Tibetan medicine made quite a lot and for promoting of drugs of horns of deer at the most various diseases. Drugs from horns of a dappled deer are included in the Chinese pharmacopeia in 1596 at the initiative of the doctor Li-shi-dzhenya. These drugs receive from a show off (lu-zhun), ossified horns (๖็่๎) and bloods (Xue). The monument of medieval Tibetan culture of Chzhud-sha mentioned earlier stores data on medicinal preparations from animal raw materials (horns of deer) who it is wide and with success were used in those days. The historical data which reached us demonstrate that it is drugs which, first of all, have effect at diseases of the central nervous system, endocrine organs, the genitourinary sphere and internals. They are prescribed at the general delicacy as tonics, when weakening sex functions at advanced and young age, as well as according to other indications.

Since then value of medicines from horns of deer didn't decrease at all, despite an impact of synthetic drugs in connection with development of chemical synthesis and pharmacological search in all directions (the referred synthesis of derivatives and metabolites, screening, etc.).

In 1968 the first international congress "Panta and Pantocrinum" was carried out and the materials concerning medical use of drug Pantocrinum are published. In Russia in 1993 very substantial book of A. M. Yudin "Panta and antler" which has help character concerning biological activity of a show off and antler (ossified horns) of dappled deer, maral, Manchurian deer, the European and northern deer, saiga and other animals is published small on volume, but. Literary data on biological activity, methods of conservation, chemical composition and a clinical use of drugs from horns of deer are analyzed.

It was reported that in east medicine not only horns or pant of deer, but also and tails, germs, sinews, gonads, penises, blood, bones, skin and other bodies use. In the Far East medicines from horns of deer applied hundreds of years as monotherapy, as well as in a combination with other adaptogens — a ginseng, the Chinese magnolia vine and products of the increased biological value — honey, nuts and others.

The basic and practical researches of foreign authors concerning medicines from a show off and antler allowed to establish new chemical features and pharmacological properties of these medicines, such as increase in synthesis of protein, nucleonic acids, influence on kinetics of biochemical reactions in an organism, and also on capability of muscle cells in culture, ultra structure of cages, anti-inflammatory effect and other phenomena.

Horns of a Manchurian deer, maral, dappled deer used already for a long time, and horns of a reindeer, elk and saiga only in the last decades. If to compare a ratio of medicinal raw materials from dappled deers and reindeers, then it constitutes 1:20.

The chemical composition of a show off at different types of deer is researched by many authors. Among biologically active ingredients in horns lipids are found (phospholipids, mono - and triglycerides, sterols, free fatty acids, triatsilglitserola, air of sterols and others). The phospholipid fraction of flour of a show off of maral is found lecithin and lizoletsitin, sfingomiye-lean, colamincefalin, tserebrozid, cardiolipin and amino acids, and also prostaglandins and other ingredients.

Also steroid connections are found in low concentration: estrone, testosterone, progesterone and cholesterol, are revealed also inorganic elements: ัเ, Mg, Fe, Si, P, Na, To, and also traces of V, Sr, Mo and Century. Among amino acids glycine, alanine, proline, glyutaminic acid and some peptides are found. Most of authors pay attention to imperfection of methods of extraction in case of release of biologically active agents from a show off which can go to production wastes. Thus, the chemical composition of horns of deer is represented quite difficult and various what a priori can testify to a wide range of pharmacological effect of medicines.

Biological activity of medicines from horns of deer depends on age of animals, time of procurement, a method of conservation, technology of preparation of medicines and many other reasons.

Medicines from horns of deer are applied outwardly and inside, men, women and children in case of violations of functions of nervous and endocrine systems, diseases of heart, liver, kidneys, reproductive system, infectious and many other diseases. The effect, according to researchers, after a course of treatment can proceed up to one and a half months.

The nature of a show off allows application them as in the natural form, and in the form of extracts. Medicines from horns of a reindeer received various names: rantarin, velcornip, epsorin, sibirin.

Fixed expansion of ideas of adaptogens and their list, data about adaptogen properties allows with good causes to consider officinal, food, edible, fodder plants as natural guards of a biochemical, functional and structural homeostasis of mammals. It is undoubted trophic, energy, information, reproductive (and for the person — esthetic) dependence of representatives of fauna on representatives of flora. All this shall be the basis, ideological and methodical base of search of new medicines of phytogenesis and their further clinical use for the purpose of increase in efficiency of treatment and prevention of diseases including at athletes, and also for increase in general and special efficiency of athletes.

Classification of adaptogens:

1. Phytogenesis medicines

1.1. Monomedicines — tincture and liquid extract of a ginseng; magnolia vine tincture; liquid extract of an eleuterococcus; liquid extract of levzea; ecdisteron; araliya tincture; saparat; tincture and liquid extract of ekhinatsea; immunat; sterkuliya tincture; zamanikha tincture.

1.2. The combined medicines — an elixir Graal; Vigor balm; complex Vitastim tincture, elixir Svyatogor; elixirs "Anti-stress ์ๅํ'๑ formula"; "Anti-stress ladys formula", power tonic, Monomakh balm, medicines "Yanshen Hubao", "Ginseng Royal Jelly", etc.

2. Medicines of an animal origin of pancriotin, panticrin, pantogematogen (extract from not ossified horns ofmaral, Manchurian deer or dappled deer, and also a bone, teeth, sinews, blood, a brain, meat, bile), musk (a secret of musky gland of a musk deer), a rhinoceros horn (in case of depletion and impotence, anti-toxic, febrifugal and anti-toxic means), lipotserebrin (medicine of brain fabric of cattle), powder from bones of tigers and a bear, fresh and tinned blood, muscles of snakes (especially Japanese already), skin and hedgehog meat, fresh snails extract, powder from dried crickets, sinks and reptiles (in Southeast Asia), spiders and the scorpions (as comforting narcotic and anti-toxic means), worms, bloodsuckers, beekeeping products are perga, flower pollen, a uterine milk (a ginseng + a uterine milk), comb honey from a framework of a long-term exposition, honey with medicines of adaptogens (a ginseng, rhodiola pink, levzey, etc.), medicines from marine and oceanic animals — Cucumariae, sea lions and other mammals, mussels, a scallop, sea turtles, etc.

3. Medicines of a mineral origin is a mummy.

4. Vitamin medicines.

Pharmacokinetics. Medicines of all adaptogens are quickly and completely soaked up in the digestive channel, distributed in all bodies and systems. Are allocated mainly with urine, an insignificant part — with excrements.

Pharmakodinamika. The mechanism of action of adaptogens is connected with their activating influence on exchange processes. Medicines it is more expressed - but stimulate processes of oxidizing phosphorylation, at a hypoxia and extreme situations, adverse environmental conditions normalized - indicators of power and nucleinic exchange, possessed antioxidant action (increasing activity of factors of antioxidant protection and oppressing oxidation of lipids). Medicines show its action; for the majority of medicines anti-hypoxemic activity is established. Adaptogens can stimulate biosynthesis of catecholamines also. The last property defines need of purpose of adaptogens in the morning or if necessary — 2 — 3-times reception in the first half of day.

For athletes morning reception as it coincides with their physiological morning rise, activation of metabolic processes in an organism and night reduction of activity of these processes is important. Besides, various adaptogens differentially (it is most expressed medicines) exert immunotropny impact.

Main effects of adaptogens:

1. Moderate stimulation of mental and physical working capacity. This property at vegetable adaptogens generally is implemented thanks to the content of alkaloids.

It is necessary to mark that such effect is shown in case of reception of adaptogens in heavy doses (25 — 50 drops on reception) while medicines in insignificant doses (2 — 10 drops on reception) can possess preferential reverse action, exert the oppressing impact on TsNS at separate individuals, cause block, activity reduction, constant drowsiness.

2. Increase in resistance of an organism to unfavorable factors by adaptive reorganization of a metabolism, including in case of implementation of radio tire-tread effect.

3. Antis tress influence.

4. Increase in sensitivity of visual and acoustical analyzers.

5. Haemo poetic effect.

6. Improving of function of a myocardium, liver and other organs.

7. Acceleration of processes of regeneration, reparation, immune modulator action.

8. The normalizing and moderate stimulation of function of endocrine system.

9. Stimulation of sexual function.

It is necessary to consider that anabolic action of vegetable adaptogens is implemented only against the background of training influence therefore it is necessary to apply them in case of adequate physical activities. As all called medicines have properties to strengthen processes of excitation and braking in TsNS, it is very important to be able to observe their correct dosage, and also to observe time slots of reception.

In case of assignment of vegetable adaptogens it is necessary to consider dynamics of daily biorhythms, and then there will be possible a gain (synchronization) last. The wrong assignment of medicines can cause violation of daily biorhythms. As a reference point it is necessary to use daily ekskretion of catecholamine which amplifies in the morning and reaches a maximum in the first half of day.

Further more detailed description of the most widespread (and available) adaptogens which can be used for maintenance of a normal functional state of different systems of an organism and increase in the functional reserves is provided now. It is necessary to mark that different adaptogens differ not only in force, but also an action range that should be considered in case of their application in each case.


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Agmatine

28 Nov 2016

Agmatine is a sports additive (agmatine sulfate) which is often presented as the most active form of the donator of nitrogen as an arginine, however, if to compare effects, has with it few common features. In pharmacology agmatine the protecting brain from ischemic damage is presented as nootrop, it is also perspective for treatment of neuropathic pain and a drug addiction. Positive effects on sports indicators and body height of muscles are directly not proved, but well proved.

Agmatine 500

It is open and called in 1910 the German scientific Albrecht Kossel which allocated agmatine from milts of a herring. From the chemical point of view, is biogenic amine which is formed of L-arginine by decarboxylation (excision of carboxyl group). Agmatine is also present at a human body, acting as a neurotransmitter, it is deposited in some neurons and released at their activation. You can also like Ventramin.

Mechanism of action

The molecule of agmatine has pleyotropny (various) biological effect and has several proved mechanisms which can be useful to athletes.

Increases activity of eNOS

NOS (nitric oxide synthase) is an enzyme which synthesizes nitrogen oxide. There are three types of this enzyme: iNOS (immune), nNOS (nervous) and eNOS (vascular). The first two look is suppressed agmatiny, however rising of level and activity of eNOS was experimentally shown. It is known that nitrogen oxide is multipurpose and is formed in many cells and tissues. In bodybuilding interest is attracted only by eNOS as it carries out synthesis of nitrogen oxide in a blood that leads to expansion of a capillary bed and improvement of a delivery of muscular tissue. Thus, this mechanism can theoretically facilitate transport of nutrients and oxygen, to promote restoration of muscles and to provide pamping.

Activation imidazolin receptors

A number of researches proved activation of imidazolin retsepetor definitively, moreover agmatine of imidazolin receptors is endogenous (natural) ligand. Known pharmacological medicines mocsobidin and rilmenidin, applied to a lowering of arterial pressure belong to I1-imidazolinovykh agonists of receptors.

In case of activation of imidazolin receptors the following effects develop:

  • the suppression of sympathetic nervous system (comforting action)
  • decrease in secretion of adrenaline and other catecholamine
  • expansion of vessels and decrease in level of arterial pressure
  • increase in secretion of anabolic hormone of insulin and improvement of power supply of fabrics
  • strengthening of a lipoliz (combustion of fat)
  • reducing products of lactic acid

Side effects: Therapy by I1-imidazolinovykh agonists of receptors is followed by development of a number of side effects, such as drowsiness or sleeplessness, adyname, a headache, dizziness, weakness in case of physical activities, sensation of fear, a depression, spasms, heartbeat, a cold snap of extremities, orthostatic hypotension, inflows, dryness in a mouth, pain in epigastria, diarrhea, nausea, a lock, peripheral hypostases, disorders of sexual function, skin rashes, an itch.

Curve of concentration of gonadotrophin (LG) after introduction

Stimulates secretion of gonadotrophin and gonadoliberin

It is known that these two peptides are capable to raise products of own testosterone. Positive influence on secretion of gonadotrophin (lutenizing hormone) and gonadorelin was revealed only to work of 1995 on rats. At the same time agmatine was entered into brain ventricles. Similar results were received by M. Kovac, J. Gulyas in 1988 in case of intravenous administration of GHRG peptide with replacement in the amino-acid sequence of an arginin on agmatine.

Blocking of NMDA of receptors

This mechanism continues to be studied actively as is of great importance for neuropatronage. However in bodybuilding isn't of particular interest.

Release of endorphins

Due to release of beta endorphin and increase in sensitivity of opioid receptors possesses the anesthetizing action. At the same time doesn't cause dependence.

Besides, activation of serotonin and alfa2-adrenoceptors, blocking of nicotinic receptors, activation of PI3K/Akt and adenylate cyclase is found.

Feedbacks of the expert

Apparently from the description of mechanisms, agmatine sulfate realizes the main action not at the expense of nitrogen oxide. It is only one of many mechanisms which advantage is very doubtful. Moreover, there is a research which showed that nitrogen oxide suppresses synthesis of own steroid hormones (testosterone) in testicles.

Despite it, imidazolin mechanism looks very attractive and well reasonable. "Attention" Should be noticed that perhaps notable decrease in power indicators and activity during the training, due to sedative action and decrease in level of catecholamines (though many producers suggest otherwise, in the section of mechanisms there is a confirmatory footnote) therefore for security officers additive can play a negative role though as a part of pretraining complexes it can be unnoticed due to additional inclusion of stimulators. Also there is open a question of bioavailability of agmatine of sulfate which is used in all sports additives.

Sports food

  • AGMATINE 500 from USP labs
  • Agmatine from Serious Nutrition Solutions
  • Hybrid N.O. from MusclePharm
  • Jack3d Micro (USPlabs)
  • Fierce Domination from SAN
  • Testogen-XR from Ronnie Coleman
  • MOAB from Muscle Warfare
  • Cannibal Perma Swole from Chaos & Pain
  • Insane Veinz from Insane Labz

Acceptation course

About 500 - 1000 mg approximately in 45 minutes before a training are recommended to accept, or at any time during rest together with food. The maximum recommended dose constitutes 6,000 mg, according to the data MayoClinic.com. It is possible to combine with other sports food. The optimum duration of administration is accurately not regulated, about 1-2 months.


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Agent for pamping

28 Nov 2016

Many people who professionally go in for bodybuilding or just fans don't think of the trainings without so-called fullness of a blood of muscles or pamping. Carrying out a huge number of approaches and repetitions not it turns out to achieve that rating about which the great athlete of all times and the people Arnold Schwarzenegger spoke from everyone. But not everything is as difficult as can seem. For today in drugstores of Russia it is possible with ease and without prescription to buy not banned drug which is named Agapurin. Also names Trental or Pentoxifylline are possible. This drug in tablets is produced. Usually in one packing of 60 tablets on 100 mg. On average, drug cost slightly exceeds 100 rubles for packing. Also exists it is long the current version Agapurin Retard in tablets on 400 mg.

Agapurin,Trentale, Pentoxifylline

Agapurin is high active agent which dilates blood vessels, as a result there is an intensifying of a blood flow and improvement of microcirculation in muscular tissue, viscosity of a blood decreases. Those who tried Agapurin during the trainings, told about the feeling of the strongest rating sometimes surpassing in the force feelings from use of such drugs which is breaking off muscles as Enanatat and Tsipionat (Aethers of men's hormone of Testosteron-Depotum). Stronger feelings can achieve if to combine Agapurin with Aspirin and RR vitamin. These drugs in bodybuilding for development of capillary network in muscles which is absolutely necessary for pamping and body height of muscles are used.

Course. In practice, Agapurin is used according to the following scheme: day of training – 2 tablets after food three times a day, day of rest – 1 tablet after food three times a day. After three weeks of reception according to this scheme of Agapurin it is necessary to take a break lasting a month. Just during this break it is necessary to return to the ordinary trainings to approach a new stage of pamping with the increased working balances.

AGAPURIN (Pentoxifylline)

structure and release form

Active ingredient is oentocsifillin.

1 ml of solution for injections contains Pentoxifylline of 20 mg; in ampoules on 5 ml, in a box - 5 pieces.

1 dragees - 100 mg; in vials of dark glass - 60 pieces.

Pharmacokinetics

It is soaked up quickly, from the prolonged form it is released slowly, the maximum concentration is defined in 2 hours after reception (in 12 hours decreases to 25%). It is distributed evenly, removed by kidneys (about 94%) and an intestine (about 4%) in the form of metabolites (only about 2% - in not changed look); in the first 4 hours about 90% of a dose is removed.

Indications to use

  • Disturbances of periphery circulation during an exercise stress.
  • Trophic disturbances (varicose ulcers, frostbites, etc.).
  • Angioneyropatiya (paresthesia, Crocq's disease).
  • Disturbances of cerebral circulation (atherosclerosis), acute and chronic failure of blood supply of a mesh and vascular cover of an eye; acute functional disorders of an inner ear.

Contraindications

Acute myocardial infarction, massive bleeding, cerebral hemorrhages.

Side effects

Dyspeptic phenomena, giddiness, feeling of fever, itch, urticaria.

Interaction

Synergy with antihypertensive (sympatholytics, ganglioblokator, vazodilatator, etc.).

Route of administration and doses

Inside, after food, without chewing, washing down with a small amount of liquid, 2 dragees 3 times a day within 1 week; at sharp dropping of the ABP the dose is reduced to 1 dragee by 3 times a day, the same doses apply at a long course of treatment.

V/v (struyno or by drop infusion), intravenously (struyno or by drop infusion), intramuscularly. The dose and the scheme of treatment are established individually.

Precautionary measures

It is necessary to apply under control of the ABP: at hypotension and lability of a circulation sharp hypotension and an attack of stenocardia can develop. At a heart failure administration of cardiac glycosides is necessary. At the patients with a diabetes mellitus accepting hypoglycemic agents, purpose of high doses of Agapurin can cause the expressed hypoglycemia therefore doses of hypoglycemic agents have to be corrected.


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Chewing gum with caffeine Vitale XD

28 Nov 2016

Chewing gum with caffeine Vitale XD is intended for delivery in coffeine organism through an oral cavity mucosa. It is claimed that such way is three times more effective, in comparison with capsules or tablets as active agent comes to a blood stream at once, passing a liver.

Chewing gum with caffeine Vitale XD

Description of the producer

Structure: coffeine of 50 mg, ksilitol, natural fragrance of mint taste, chewing weight.

Use: the adult on 1 chewable tablet to 3 times a day. The tablet should be chewed.

"Attention" the Overdosage of coffeine can cause an overexcitement, sleeplessness, heartbeat acceleration, or to lead to oppression of a nervous system that is shown in a strong sleepiness and fatigue. 

Coffeine excitingly influences the central nervous system, accelerates psychomotor reactions and improves concentration of attention. Is a strong power engineering specialist, helping to cope with feeling of fatigue and sleepiness. Promotes rising of mental and physical working capacity, endurance to exercise stresses, restoring force after the trainings in the gym or physical work. Besides, promotes elimination of headache (migraine). Do not forget take Tiramin for better results.

Getting into a human body, coffeine blocks receptors of hormone of an adenosine which slows down nervous impulses and causes a sleepiness. Thus coffeine interferes with slackness, increases the level of concentration of attention and rate of reactions. Coffeine stimulates release of the adrenaline enlarging heart rate, increasing pressure, enlarging a blood stream to muscles and provoking entering of a glucose in a blood from its depot in a liver. Besides, coffeine increases Dofamin level – hormone of satisfaction and happiness.

In one chewing gum the content of caffeine corresponds to 1 cup of double espresso. It is recommended to accept as necessary during the day. To chew not less than 5 minutes.

Ksilitol is the most useful to health of teeth Saccharum substitute. It has the properties containing growth of pathogenic bacteria in an oral cavity and thus promotes depression of risk of development of caries and prevention of formation of an unpleasant smell from a mouth.

Contraindications: individual intolerance of the dietary supplements components, pregnancy, feeding by a breast. Before the use it is recommended to consult with the doctor. It isn't a medicine.


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XLS MEDICAL

28 Nov 2016

XLS MEDICAL is an European agent for weight reduction, till 2015 - XLS MEDICAL Fat Binder (English Svyazyvatel of fats). Besides, XL‣S MEDICAL is the name of a brand under which Carb Blocker are also issued (English. Blocker of carbohydrates), Appetite Reducer (English Umenshitel of appetite) and MAX Strength (English. Maximum force). Agents of XLS MEDICAL are registered in Europe as agents of medical prescription (Class IIb Medical Device products) and are applied to treatment of an obesity and excess weight; in Russia only XLS MEDICAL Fat Binder (in the form of tablets and a sachet) which is registered as dietary supplement officially is on sale, i.e. isn't medicine.

XLS MEDICAL

According to statements of the producer, the Belgian pharmaceutical company Omega Pharma, XLS MEDICAL binds up to 28% of fats from a nutrition, reduces feeling of hunger and as a result "helps to lose larger weight to 3 times, than only on a diet" as Justifications for the declared properties and the proof of efficiency serve results of several clinical trials of the main Litramine active ingredient and its precursor of NeOpuntia which are carried out in Germany in 2007-2012. You can try Tiramin

Structure

Active ingredients: Litramineฎ, the patented complex of fibers of a plant Opuntia ficus-indisa - 500 mg.

Other ingredients: vitamin A (Retinolum) - 133,33 mkg, D3 vitamin (kholecaltsiferol) - 0,83 mkg, vitamin E (alpha tocopherol) - 1,67 mg.

Excipients: microcrystallic cellulose, carboxymethylcellulose, magnesium stearate, calcium hydrogen Natrii phosphas dihydrate, chlorofillin, silicon dioxide.

Contraindications

Age less than 18 years, pregnancy, lactemia, BWI (body weight index) less than 18.5

Diseases of kidneys (as the agent contains residual amount of the oxalic acid which is present at green plants)

Osteoporosis or the increased risk of an osteoporosis (as the agent contains vitamin A in the form of Retinolum)

Side effects

In the application instruction of XLS MEDICAL it is specified that cases of emergence of undesirable side effects are single (≤ 0,01%) and represent reactions of a hypersensitivity at food allergy: rashes, itch, insignificant edemas and mild gastrointestinal disorders. The producer recommends to stop reception of an agent in these cases. Also there can be a constipation at the insufficient use of liquid.

In responses of those who accepted XLS MEDICAL if complaints, then on disorders of a GIT meet.

Responses

At specialized forums a set of responses about an agent of XLS MEDICAL from which it is possible to get some idea about efficiency and safety of these tablets for weight loss.

Rather often XLS wrongly or deliberately attribute action to all the known medicine of Xenical, however, at similar influence on assimilation of fats in a GIT, these agents possess different mechanisms of action. Orlistat (active ingredient of Xenical) is bound to enzymes - the gastric and pancreatic lipase which is responsible for splitting of fats owing to what in an intestine there is a part of free undigested fats capable to cause unpleasant side effects. Litramine as a part of XLS binds (absorbs) the same part of fats vegetable fibers, without leaving free undigested fats and without causing characteristic side effects of orlistat.

The producer positions XLS MEDICAL as the assistant in fight against excess weight in a complex with the balanced delivery and moderate physical activity. By results of researches, at respect for the principles of a healthy delivery of XLS MEDICAL can enlarge effectiveness of fight against excess weight.


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How DNA with synthetic nucleotides was built into a living cell?

28 Nov 2016

About the central dogma of molecular biology, and increase the information capacity of DNA.


DNA, Vitamin B12 , Cyanocobalamin injection buy

In May 2014 in the journal Nature published an article in which it was stated on the establishment, implementation and replication in a living cell, DNA molecules with a pair of artificial nucleotides.

In order to understand the essence of this study should be a good understanding of the flow of information in a cell, which describes the central dogma of molecular biology, proposed in his time Francis Crick. The central dogma postulates that the genetic information stored in the DNA where it is "written" in the form of a linear sequence of four "letters" or bases - A (adenine), G (guanine), C (cytosine), T (thymine). This information is a code that can be translated into the "language" of proteins, which are the main carriers of biological functions. In order that the information from the DNA was translated into the "language" of the protein, it must first pass the transcription of DNA that is synthesized copy DNA region gene containing the ribonucleic acid (RNA). Portions of DNA (or RNA) is 3 nucleotides in length called "triplets" (or "codons"), amino acids they encode. A total of 20 amino acid proteins encoded by the different DNA triplets. The genetic code - a set of rules by which certain triplets "translated" into a well-defined amino acids, and hence, genetic information, DNA triplets are translated into proteins, amino acids. A linear sequence of encoded amino acids and of protein. Sam conversion process is very complex and takes place in a process called "translation". The injection of Vitamin B12 (Cyanocobalamin injection) - is extremely essential for DNA synthesis making.

There is a great desire to increase the data capacity of the genetic code. I do not want to have 20 amino acids, 21 or 22 or 23 and t. D. Thus, we could not enter natural, and some specific amino acids in proteins interesting properties and may obtain proteins with novel properties. Work Romesberg et al. - Is an attempt to move in this direction. To learn how to encode new amino acids, they decided to create a DNA molecule which contains no base 4, and 6. In order to do this, much preliminary work has been done. The article is called quite pathetic - "Semi-synthetic organism with an expanded genetic alphabet." Really been done is this: DNA, as is known, is composed of two chains, which are self-complementary. In a chain of A, another chain in front of her T; in the same D, on the other hand - C. Thus, if the chain split, it turns out that in each of them individually is completely contained information for the construction of the remainder of the circuit. The authors of this article have found a pair of substances (called unnatural, non-natural analogs of DNA bases) that are not A, and T, and C, and D, but behave in the same way, that is capable of complementarily interact with each other . Methods of synthetic chemistry they created a version of the self-replicating DNA molecule of about 2,500 nucleotides in length, that are completely consistent with the well-known standard version, with the exception of a single base pair, ie one unnatural "letters" in the same chain, and its complementary unnatural "letters" across the street. It was found that under certain conditions, cell bacteria E. coli can replicate a DNA molecule that is copied, and daughter molecules will also be this "wrong" letters couple in the same position as that of the parent molecule. That is, information is a non-paired bases inherited.

That this result can be achieved in vitro using purified enzymes that replicate DNA has long been known. A major breakthrough is in the fact that they have been demonstrated to copy DNA molecule containing the unnatural base pair in a living cell. For this purpose it was necessary to the cell of E. coli, which was introduced a synthetic DNA containing a specific molecule-transporter protein, which would provide transport into the cell precursors of non-natural bases from the nutrient medium.

Because it should be understood the foregoing that the result of this to demonstrate that they actually managed to expand the genetic code, it is very, very far away. That is, if we assume that the purpose of the possibility of constructing proteins, containing more than 20 amino acids, it is a matter for at least another few years of hard work, because we must also learn how to encode "new" DNA language in some special protein 'language'.


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The medicine Winstrol 75 (Stanazolol)

28 Nov 2016

"Winstrol 75" developed the MaxPro Pharma company is one of the most favourite steroids among athletes. It is also known under the names "Stanozolol", "Strombaject Aqua", "Stan", "Vinstrol", "Stanazolol". Examples of sports practice in the world say that medicine is very effective in case of competent use.

Winstrol 75, Stanazolol

Effect and effect of medicine

Feature of "Winstrol 75" is that active agent is dissolved in water, but not in oil as the most part of steroids. In spite of the fact that all bodybuilders know this difference, in practice seldom use.

Intervals between entering of medicine shall be shorter, than when using other steroids. It is connected with short time of half-decay of the steroids dissolved in water: they quickly get to blood, but work very not for long. Do not forget take Hepatamin for better results.

The operating chemical of medicine is derivative dihydrotestosterone therefore it isn't flavored and very seldom causes a delay in a liquid organism.

Use of stanozolol in sport

"Winstrol 75" gives to muscles elasticity and hardness if to combine it with a protein-rich diet with a small amount of calories. When using a diet, it doesn’t mean that it used as the unique steroid as its androgenic activity very low.

Weak manifestation of androgenic impact is compensated by a medicine combination with "Trenbolone". The combination from 50 mg of stanozolol and 30 mg of trenbolone enjoyed wide popularity among athletes of the 80th years. Today in parallel the medicines "Primobolan", "Oksandrolon", "Testosterone propionate", Boldenon, etc. are successfully used.

"Attention" Recommended dosages of Winsrtol 75 from MaxPro Pharma: 1ml /days


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Mastodynon 50ml drops