Cavinton forte (Vinpocetine) tablets - Instructions for Use, Dosage, Side Effects, Reviews

Synonyms: Intelectol

Active substance: Vinpocetine.

Vinpocetine (brand names: Cavinton, Intelectol; chemical name: ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine (sometimes described as "a synthetic ethyl ester of apovincamine"), an extract from the lesser periwinkle plant. You can buy Cavinton forte.

Vinpocetine is not FDA approved in the United States for therapeutic use.

Vinpocetine has been reported to have cerebral blood-flow enhancing and neuroprotective effects, and has been used as a drug in Eastern Europe for the treatment of cerebrovascular disorders and age-related memory impairment.

ATC - N06BX18 Vinpocetine.

Pharmacological group - Cerebrovascular correctors; Nootropics.

Nosological classification (ICD–10)

F01 Vascular dementia;

G45 Transient transient cerebral ischemic attacks [ attack ] and related syndromes;

G45.0 syndrome vertebrobasilar arterial system;

G46 Vascular syndromes of brain in cerebrovascular diseases;

G93.4 Encephalopathy, unspecified;

H31.9 Disorders of choroid, unspecified;

H35.9 Retinal disease, unspecified;

H81.0 Meniere’s Disease;

H91 Other hearing loss;

H93.1 Tinnitus (subjective);

I63 Cerebral infarction;

I67.2 Cerebral atherosclerosis;

I67.4 Hypertensive encephalopathy;

I67.9 Cerebrovascular disease, unspecified;

I69 Effects of cerebrovascular diseases;

T90.5 Effects of intracranial injury

Cavinton (Vinpocetine) Composition, structure and packing

Tablets are round, flat, white, or almost white, with a facet, with the inscription “10 mg” on one side and scored - on the other.

Other ingredients: magnesium stearate, colloidal silicon dioxide, talc, lactose monohydrate, maize starch.

Cavinton (Vinpocetine) Pharmacological action

The drug, which improves cerebral blood flow and cerebral metabolism. Improves brain metabolism, increasing consumption of glucose and oxygen to the tissues of the brain. Increases the resistance of neurons to hypoxia, enhancing the transport of glucose to the brain through the BBB; takes the process of breakdown of glucose for energy more economical aerobic way; selectively blocks Ca 2 +-dependent phosphodiesterase, increases the levels of cAMP and cGMP in the brain. Increases the concentration of ATP and the ATP/AMP in brain tissue, strengthens the exchange of norepinephrine and serotonin brain, stimulates the ascending branch of the noradrenergic system, has an antioxidant effect.

Reduces platelet aggregation and increased blood viscosity, increases the ability of red blood cells deform and blocks recycling erythrocytes adenosine; enhances oxygen release erythrocytes. Enhances the neuroprotective effects of adenosine.

Increases cerebral blood flow, reduces the resistance of cerebral vessels without significant changes in indicators of the systemic circulation (blood pressure, cardiac output, heart rate, systemic vascular resistance). Not only has the effect of “steal”, but also enhances the blood circulation especially in ischemic areas brain with low perfusion.

Cavinton (Vinpocetine) Pharmacokinetics

Absorption

After ingestion is rapidly absorbed. C max in plasma is reached after 1 h after administration. Absorption occurs mainly in the proximal gastrointestinal tract. When passing through the intestinal wall is not subjected to metabolism. C max in the tissues observed after 2–4 hours after ingestion. Bioavailability of 7%.

Distribution

In repeated oral dose of 5 mg and 10 mg kinetics is linear.

Bound to plasma proteins at 66%. Crosses the placental barrier.

Metabolism and excretion

Clearance 66.7 l/h exceeds liver plasma volume (50 l/h) which indicates extrahepatic metabolism.

T 1/2 is 4.83 ± 1.29ch. Excreted in the urine and feces at a ratio of 3:2.

Cavinton (Vinpocetine)Dosage

The duration of treatment and dose are determined individually.

Average daily dose is 15–30 mg (5–10 mg 3 times/day). The initial daily dose is 15 mg. The maximum daily dose - 30 mg.

The therapeutic effect develops in about a week since the beginning of treatment. To achieve the full therapeutic effect requires three months.

Renal impairment and liver correct dosing regimen is not required, the lack of cumulation allows for longer courses of treatment.

Cavinton (Vinpocetine) Overdose

Currently, data on drug overdose Cavinton Forte limited.

Treatment: gastric lavage, activated charcoal, symptomatic therapy.

Cavinton (Vinpocetine) Drug Interactions

Interaction is not observed, while the use of beta-blockers (hloranolol, pindolol) clopamide, glibenclamide, digoxin, acenocoumarol and hydrochlorothiazide, imipramine.

Simultaneous use of the drug methyldopa Cavinton Forte and sometimes caused some increased hypotensive effect, so the application of this combination requires regular monitoring of blood pressure.

Despite the lack of evidence supporting the possibility of interaction, caution is advised while appointing Cavinton Forte with centrally acting agents, antiarrhythmic drugs and anticoagulants.

Cavinton (Vinpocetine) at Pregnancy and lactation

Cavintonum Forte is contraindicated during pregnancy because vinpocetine crosses the placental barrier. Thus its concentration in the placenta and fetal blood is lower than in the blood of pregnant. When taken in high doses may develop placental bleeding and spontaneous abortions, probably due to increased placental blood supply.

Within 1 h with breast milk allocated 0.25% of the dose of the drug. If necessary, use during lactation should stop breastfeeding.

Cavinton (Vinpocetine) Side effects

Cardio-vascular system: ECG changes (depression ST, prolongation of the interval QT); tachycardia, arrythmia (however, a causal relationship has not been proven as a natural population of these symptoms occur with the same frequency), the lability of blood pressure, feeling the tides.

CNS: sleep disorders (insomnia, hypersomnia), dizziness, headache, general weakness (these symptoms may be manifestations of the underlying disease), increased sweating.

From the digestive system: dry mouth, nausea, heartburn.

Allergic reactions: skin rash, urticaria.

Cavinton (Vinpocetine) Indications

To reduce the severity of neurological and psychiatric symptoms in various forms of circulatory failure, brain (including status after ischemic stroke, hemorrhagic stroke recovery stage, the effects of a stroke, transient ischemic attack, vascular dementia, vertebrobasilar insufficiency, cerebral arteriosclerosis, posttraumatic and hypertensive encephalopathy);

Chronic eye disease (lesions of the choroid and retina);

In ENT practice (for the treatment of hearing loss perceptual type, Meniere’s disease, idiopathic tinnitus).

Cavinton (Vinpocetine) Contraindications

The acute phase of hemorrhagic stroke;

A severe form of coronary artery disease;

Severe arrhythmias;

Pregnancy;

Lactation (breastfeeding);

Children up to age 18;

Hypersensitivity to vinpocetine or other ingredients.

Cavinton (Vinpocetine) Cautions

Presence of a syndrome of prolonged QT interval, and concomitant use of drugs that cause prolongation of the interval QT, requires periodic monitoring of ECG. In the case of lactose intolerance should be aware that one tablet of the drug Cavinton Forte contains 83 mg of lactose monohydrate.

Use in Pediatrics

Cavinton Forte drug should not be prescribed to children and adolescents under the age of 18 years due to insufficient data on its use in these patients.

Effects on ability to drive vehicles and management mechanisms

Data on the effect of the drug Cavinton Forte’s ability to driving and operating mechanisms not.

Cavinton (Vinpocetine) Reviews

Samantha, 38 years, The preparation "Vinpocetine forte" - Checked personally - working!
Attention! Before application of drugs, consult with a specialist!
Advantages:
It works and it is important

Actually, it is always very cautious about medical drugs, and even more so to novelties, but in this case we are talking about a drug that works on our farm. the market for quite a long time and during that time managed to prove itself a good idea, as a means of improving brain metabolism. Indications for use of this drug is quite extensive - it's the recovery period after a stroke, sclerosis of cerebral vessels, vascular dementia, which undoubtedly is a very serious problem for the elderly! Especially when it comes to changes in the brain due to hypertensive disease or a brain injury. It uses medication and ophthalmologists, as it is one of the few drugs that improve the condition of small blood vessels in the retina of the eye, thus improving vision (including again in the elderly). of course, the drug there are contraindications and side effects, and therefore before placing them - should consult with your doctor. Here I just want to draw your attention to the drug, which is assigned to the relatives just because I believe in him and have the opportunity to see the effect it!
Overall Impression: Checked personally - working!

Helen, 48 years, Vinpocetine - Excellent tool

The weather we have recently just going crazy: yesterday went in jackets, and now the heat, it's time to get sundresses. Such transformation is affecting the health, such vessels can not cope with. Result: the fog in my head. But to live and work as something you ought to. To bring awareness to normal use Vinpocetine.

I do not seriously ill, drink it all the time is not necessary. After a day of seeing the first results of the application: the mind becomes clear, head understands much better.

In general, I recommend. Harm did not notice - is easily transferred without any side effects.